一种基于注意力权重分配与自适应残差学习的基因组预测模型

By using a deep learning model based on attention weight allocation and adaptive residual learning, the problem of insufficient global dependency capture in high-dimensional sparse SNP data by traditional genome prediction models is solved, achieving higher-precision genome prediction and supporting biological breeding and genomics research.

CN120544667BActive Publication Date: 2026-07-17ZHEJIANG UNIV

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV
Filing Date
2025-04-15
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing genome prediction models struggle to effectively capture global dependencies and complex traits among genes when processing high-dimensional sparse SNP data. Traditional models have limited prediction accuracy, and the application of attention mechanisms in genome selection has not been fully explored.

Method used

A deep learning model based on attention weight allocation and adaptive residual learning is adopted. The SNP site weights are implicitly calculated through a multi-layer fully connected network and combined with adaptive residual connections to construct a genome prediction model that captures global dependencies and preserves the original information.

Benefits of technology

It significantly improves the accuracy and efficiency of genome prediction, enhances the precision of predicting complex traits, and provides stronger support for biological breeding and genomics research.

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Abstract

本发明公开了一种基于注意力权重分配与自适应残差学习的基因组预测模型,属于基因组选择技术领域。所述方法包括以下技术步骤:获取基因遗传多态性位点的012编码矩阵,使用多层感知机(MLP)计算每个SNP位点的权重,并通过自适应残差学习机制将输入特征与权重结合,进一步在全连接神经网络中进行拟合;在模型训练完成后,输出测试集的决定系数(R2)、皮尔逊相关系数(PCC)及每个SNP位点的权重文件。本发明的创新点在于引入注意力机制,通过动态分配SNP位点的权重,从全局角度分析其对表型的影响,并结合自适应残差学习。通过SNPWeightNet.py程序实现SNP数据到表型预测的自动化,具有高精度和强可解释性的特点。
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