Hydroxyl-alpha-sanshool cyclodextrin inclusion compound as well as preparation method and application thereof

Abstract

The invention relates to the technical field of biological medicines, in particular to a hydroxyl-alpha-sanshool cyclodextrin inclusion compound as well as a preparation method and application thereof. The preparation method specifically comprises the following steps: (1) mixing hydroxyl-alpha-sanshool with hydroxypropyl-beta-cyclodextrin for reaction, and removing a solvent to obtain a reactant; and (2) filtering the reactant obtained in the step (1), and freeze-drying to obtain the hydroxyl-alpha-sanshool cyclodextrin inclusion compound. The purpose of the invention is to provide that the clinical application of HAS is limited due to poor water solubility and stability of HAS. The invention aims to construct a hydroxypropyl-beta-cyclodextrin inclusion compound system through a molecular inclusion technology so as to improve the water solubility of the HAS and increase the stability of the HAS. In addition, a gel plaster is further developed and prepared for local treatment of peripheral nerve pathological pain, and aims to avoid loss caused by the first-pass effect, improve patient discomfort caused by frequent administration and reduce side effects caused by systemic administration.

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