丝素蛋白茶多酚水凝胶及其制备方法和应用
By preparing silk fibroin tea polyphenol hydrogel, and utilizing its close adhesion to bladder tissue and molecular action in urine, the treatment challenge of hemorrhagic cystitis was solved, achieving effective hemostasis and treatment without toxic side effects.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NINGBO FIRST HOSPITAL
- Filing Date
- 2024-10-15
- Publication Date
- 2026-07-17
AI Technical Summary
Current treatments for hemorrhagic cystitis suffer from problems such as antibiotic overuse, increased drug resistance, limited symptomatic treatment effectiveness, and frequent relapses. There is a need to develop more personalized and effective treatment methods.
A silk fibroin-tea polyphenol hydrogel was prepared by mixing and reacting silk fibroin with tea polyphenols to form a hydrogel. The hydrogel was used to achieve hemostasis by its close adhesion to bladder tissue and its molecular action in urine. The hydrogel was then cured in situ at the lesion site by photocuring.
Silk fibroin and tea polyphenol hydrogel have good adhesion and hemostatic effects, can adhere closely to bladder tissue, significantly reduce submucosal bleeding, and have no toxic side effects, providing a thorough treatment for hemorrhagic cystitis.
Smart Images
Figure CN120603578B_ABST