Preparation method of pharmaceutical grade 2-mercaptobenzothiazole
By soaking in inorganic acid solution and segmented purification with polar solvents combined with sulfite treatment, the problems of large amounts of waste salt and high costs in the preparation of pharmaceutical-grade 2-mercaptobenzothiazole were solved, and the low-cost preparation of high-purity products was achieved.
Patent Information
- Application Number
- CN202510774635.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-11
- Publication Date
- 2025-09-16
AI Technical Summary
The existing technology produces a large amount of waste salt and requires the use of expensive adsorbents during the preparation of pharmaceutical-grade 2-mercaptobenzothiazole, resulting in great environmental pressure and high costs, and the product color is poor.
A staged purification method combining immersion in an inorganic acid solution with polar solvents and sulfite is used to first remove color-forming inorganic impurities, and then sulfite is used as an alkaline reducing agent to remove impurities such as acidic resins, avoiding the use of adsorbents such as activated carbon.
Significantly reduce waste salt generation, lower environmental pressure and process costs, and obtain high-purity pharmaceutical-grade 2-mercaptobenzothiazole products.