Surface enhanced Raman detection platform based on annular colloidal particle stable Pickering emulsion as well as preparation method and application of surface enhanced Raman detection platform

Abstract

The invention discloses a surface enhanced Raman detection platform based on a composite Pickering emulsion with stable annular colloidal particles as well as a preparation method and application of the surface enhanced Raman detection platform. Annular colloidal particles are selected as a solid emulsifier, and metal nanoparticles are introduced into a water phase to prepare the composite Pickering emulsion. Wherein the annular colloidal particles are assembled into a single layer on an oil-water interface, and the metal nanoparticles are assembled into an aggregate on an interface of a cavity of the annular colloidal particles and a gap interface between the annular colloidal particles so as to provide a large number of enhanced hot spots, so that a Raman signal of an analyte can be remarkably enhanced. The surface-enhanced Raman detection platform is simple and flexible in preparation method, high in detection sensitivity, high in stability and low in detection cost, the volume of a detected object required by single-time detection is small, and meanwhile, double-phase detection can be carried out. According to the invention, one or more metal nanoparticles with different materials and different shapes can be selected according to test requirements to prepare surface enhanced Raman detection platforms with different sensitivities.

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