Phyllanthus emblica and radix puerariae tablet candy capable of dispelling effects of alcohol and protecting liver

Abstract

The invention belongs to the technical field of functional food, and relates to a hangover-alleviating and liver-protecting emblic leafflower fruit and kudzuvine root tablet candy, which comprises the following components in percentage by weight: 20 to 40 percent of emblic leafflower fruit extract, 15 to 30 percent of kudzuvine root extract, 30 to 60 percent of filler, 2 to 5 percent of adhesive and 0.5 to 2 percent of lubricant. The phyllanthus emblica and the kudzuvine root which are homologous in medicine and food are used as cores, the tabletted candy is prepared through scientific proportioning and a low-temperature process, and the tabletted candy has the dual effects of accelerating hangover alleviating and protecting the liver, and is natural, safe, pleasant in taste and convenient to eat.

Description

Technical Field

[0001] The invention belongs to the technical field of functional foods and relates to a candy containing emblica buds and kudzu root tablets for sobering up and protecting the liver. Background Art

[0002] With increasing social interaction, drinking has become an integral part of many occasions. However, excessive drinking can lead to elevated blood levels of ethanol and its metabolite, acetaldehyde, causing acute alcohol poisoning (drunkenness) and hangover symptoms (such as headache, nausea, vomiting, thirst, and fatigue). More seriously, it can cause persistent liver damage, leading to fatty liver, alcoholic hepatitis, and even cirrhosis. The liver is the primary organ for alcohol metabolism, and the free radicals and acetaldehyde produced during alcohol metabolism are key factors in causing oxidative damage to liver cells and inflammatory responses.

[0003] There are a wide variety of hangover remedies on the market, including oral liquids, capsules, tablets, and beverages. Some products are unclear in their effectiveness, have complex ingredients, or contain synthetic chemicals, posing safety risks. Some products have a poor taste, impacting user experience. Still others, while effective, lack sufficient liver protection.

[0004] Phyllanthus emblica L. is rich in vitamins (especially vitamin C), polyphenols (such as gallic acid and ellagic acid), and superoxide dismutase (SOD), and possesses strong antioxidant activity. Numerous studies have confirmed that emblica and its extracts can effectively combat chemical liver damage, lower serum transaminase levels, alleviate hepatic steatosis and inflammation, promote liver cell repair, and enhance liver detoxification. Pueraria lobata (Willd.) Ohwi / Puerariathomsonii Benth., the main active ingredients of kudzu root (Pueraria lobata (Willd.) Ohwi / Puerariathomsonii Benth.), including puerarin and daidzin, are flavonoids that have been shown to significantly increase the activities of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH), accelerating the metabolic clearance of ethanol and acetaldehyde, reducing blood alcohol concentrations, and thus alleviating symptoms of intoxication and hangovers. Kudzu root also possesses antioxidant and anti-inflammatory properties.

[0005] There are no reports or mature products combining the potent liver-protecting and antioxidant properties of emblica fruit with the alcohol-resolving and metabolic-boosting effects of kudzu root to create a convenient, palatable compressed candy. Therefore, developing a compressed candy with emblica fruit and kudzu root as core ingredients that combines alcohol-resolving and liver-protecting properties has significant market value and application prospects. Summary of the Invention

[0006] The purpose of the present invention is to solve the above problems and provide a candy containing emblica buds and radix puerariae for detoxification and liver protection.

[0007] To achieve the above object, the present invention adopts the following technical solutions: A hangover-relieving and liver-protecting emblica bud and kudzu root tablet candy is prepared from the following raw materials by weight percentage: Emblica officinalis extract 20% - 40%, Pueraria root extract 15% - 30%, fillers 30% - 60%, binders 2% - 5% and lubricants 0.5% - 2%.

[0008] Further, optionally, it comprises one or more of the following components: 5% - 15% of Hovenia dulcis fruit extract; Curcumin 1% - 5%; appropriate amount of vitamin B1 and / or vitamin B6; appropriate amount of glutathione precursors (such as L-cysteine, N-acetylcysteine).

[0009] Preferably, the polyphenol content of the emblica extract is ≥ 40%, and the vitamin C content is ≥ 20%. Preferably, the puerarin content of the kudzu root extract is ≥ 30%. Preferably, the filler is selected from one or more of sorbitol, maltitol, xylitol, erythritol, microcrystalline cellulose, and pregelatinized starch.

[0010] Preferably, the binder is selected from one or more of hydroxypropyl methylcellulose (HPMC), polyvinyl pyrrolidone (PVP), and starch slurry. Preferably, the lubricant is selected from one or more of magnesium stearate, micro-powdered silica gel, and talc. The present invention also provides a method for preparing the alcohol-relief and liver-protecting emblica bud and kudzu root tablet candy, comprising the following steps: Pretreatment: Pass the emblica extract, kudzu root extract, filler, and disintegrant (if used) through an 80-100 mesh sieve for later use; Premixing: Place the sieved emblica extract, kudzu root extract, filler, disintegrant (if used), and other optional active ingredients (Hovenia dulcis fruit extract, curcumin, vitamin B1 / B6, glutathione precursor) in a blender and mix for 10-15 minutes until uniform. Preparation of soft material: Add binder solution (such as HPMC aqueous solution, PVP ethanol solution or starch slurry) to the premixed powder obtained in step 2, stirring while adding to prepare a soft material with moderate hardness; Granulation: The soft material obtained in step 3 is granulated by a swing granulator or a high-speed wet granulator; Drying: Place the wet granules obtained in step 4 in a fluidized bed dryer or hot air circulation oven and dry at 50-60°C to a moisture content of 2%-4%; Granulation: The dried granules obtained in step 5 are sieved through a 16-20 mesh sieve for granulation; Total mixing: Add the whole granules obtained in step 6 to the lubricant and flavoring agent, and mix in a mixer for 5-10 minutes until uniform; Tableting: The uniformly mixed granules obtained in step 7 are compressed into tablets of desired shape and weight using a rotary tablet press; Packaging: The compressed tablets are packed in aluminum-plastic blister packs or bottles, sealed and stored in a cool and dry place.

[0011] The beneficial effects of the present invention are as follows: Clearly synergistic efficacy: The core ingredients, Phyllanthus emblica and Pueraria root, respectively, play a key role in liver protection and antioxidant protection, while alcohol detoxification and metabolic stimulation. Their scientific combination offers complementary and synergistic benefits. Added ingredients, such as Hovenia dulcis and curcumin, further enhance the alcohol detoxification and liver protection effects. The compressed candy format allows for convenient consumption before or after alcohol consumption, ensuring immediate effectiveness.

[0012] Natural and safe: The main active ingredients are derived from traditional medicinal and edible plants, which are highly safe and have low risks from long-term or frequent consumption.

[0013] Taste optimization: By adding appropriate fillers and flavoring agents, the sour and astringent taste of the emblica fruit can be effectively reconciled, making the product sweet and sour and easy to accept.

[0014] Stable and controllable process: The preparation process is mature, the parameters are clear (such as drying temperature ≤ 60°C to protect heat-sensitive ingredients), it is easy to implement industrial production, and the product quality is stable.

[0015] Convenient to eat: The compressed candy is easy to carry, measure and take, and provides a good user experience. DETAILED DESCRIPTION

[0016] The present invention provides a hangover-relief and liver-protecting emblica and kudzu root tablet candy. The candy comprises the following components, by weight: 20%-40% emblica extract, 15%-30% kudzu root extract, 30%-60% filler, 2%-5% binder, and 0.5%-2% lubricant. The candy further comprises one or more components selected from the following group: 5%-15% Hovenia dulcis extract, 1%-5% curcumin, vitamin B1, vitamin B6, and a glutathione precursor. The emblica extract has a polyphenol content of ≥40% and a vitamin C content of ≥20%. The kudzu root extract has a puerarin content of ≥30%. The filler is selected from one or more of sorbitol, maltitol, xylitol, erythritol, microcrystalline cellulose, and pregelatinized starch. The binder is selected from one or more of hydroxypropyl methylcellulose (HPMC), polyvinyl pyrrolidone (PVP), and starch slurry. The lubricant is selected from one or more of magnesium stearate, micropowdered silica gel, and talc.

[0017] The present invention also provides a method for preparing the above-mentioned alcohol-relieving and liver-protecting emblica bud and kudzu root tablet candy, comprising the following steps: (1) pretreatment: sieving the emblica bud extract, kudzu root extract, and filler for standby use; (2) premixing: adding the emblica bud extract, kudzu root extract, filler, and optional other effective ingredients sieved in step (1) into a mixer and mixing them evenly; (3) making a soft material: adding a binder solution to the premixed powder obtained in step (2) to make a soft material; (4) granulating: making the soft material obtained in step (3) into granules; (5) drying: drying the wet granules obtained in step (4) at ≤60°C to a moisture content of 2%-4%; (6) granulating: sieving the dried granules obtained in step (5) for granulation; (7) total mixing: adding a lubricant and a flavoring agent to the granulated granules obtained in step (6) and mixing them evenly; (8) tableting: pressing the mixed granules obtained in step (7) into tablets.

[0018] The alcohol-relieving and liver-protecting emblica bud and radix puerariae tablet candies of the present invention and the preparation method thereof are described below through specific examples.

[0019] Example 1: Preparation of Basic Formula Compressed Candy Formula: Emblic extract (polyphenol content ≥ 45%) 30%, Pueraria extract (puerarin content ≥ 35%) 20%, Sorbitol 42.3%, Microcrystalline cellulose 5%, Hydroxypropyl methylcellulose 1.5%, Magnesium stearate 1%, Stevioside (flavoring agent - sweetener) 0.1% and Lemon flavor (flavoring agent - essence) 0.1%.

[0020] Preparation method: Pretreatment: Pass the emblica extract, kudzu root extract, sorbitol and microcrystalline cellulose through an 80-mesh sieve respectively for later use.

[0021] Premixing: Put the sieved emblica extract, kudzu root extract, sorbitol and microcrystalline cellulose into a three-dimensional motion mixer and mix for 15 minutes until uniform.

[0022] Prepare the soft material: Dissolve HPMC in water to make a 5% (w / v) solution. While stirring, slowly add the HPMC solution to the premixed powder from step 2. Continue stirring until a soft material forms that forms a cohesive mass when held and disintegrates when touched.

[0023] Granulation: The soft material was passed through a 20-mesh screen using an oscillating granulator to form wet granules.

[0024] Drying: The wet granules were placed in a fluidized bed dryer with the air inlet temperature set at 55°C and dried until the moisture content of the granules was 3.0%.

[0025] Granulation: Pass the dried granules through an 18-mesh sieve.

[0026] Total mixing: Add magnesium stearate, steviol glycosides and lemon essence to the granules after granulation, and mix in a mixer for 8 minutes until uniform.

[0027] Tablet pressing: Use a rotary tablet press, set the tablet weight to 1.0 g / tablet, control the hardness at 5-7 kg, and press into round tablets.

[0028] Packaging: After tableting, immediately pack in aluminum-plastic blister packing.

[0029] Example 2: Preparation of Fortified Formula Compressed Candy (Containing Hovenia dulcis Fruit and Curcumin) formula: Emblica officinalis extract (polyphenol content ≥45%): 25%; Pueraria root extract (puerarin content ≥35%): 25%; Hovenia dulcis fruit extract (dihydromyricetin ≥10%): 8%; Curcumin (95%): 2%; Maltitol (bulking agent): 32.8%; Microcrystalline cellulose (filler): 5%; Polyvinylpyrrolidone (PVP K30, adhesive): 1.0% (prepared into 10% ethanol solution); Magnesium stearate (lubricant): 0.8%; Micronized silica gel (glidant / lubricant): 0.2%; Mogroside (flavoring agent - sweetener): 0.1%; Emblic flavor (flavoring agent - flavor): 0.1%.

[0030] Preparation method: Pretreatment: Pass the emblica fruit extract, kudzu root extract, Hovenia dulcis fruit extract, curcumin, maltitol and microcrystalline cellulose through a 100-mesh sieve respectively for later use.

[0031] Premixing: Put the sieved emblica extract, kudzu root extract, hovenia dulcis extract, curcumin, maltitol and microcrystalline cellulose into a V-type mixer and mix for 12 minutes until uniform.

[0032] Prepare the soft material: Dissolve PVP K30 in 70% ethanol to make a 10% (w / v) solution. Slowly add the PVP ethanol solution to the premixed powder from step 2 while stirring. Continue stirring until a suitable soft material is formed.

[0033] Granulation: The soft material was granulated by a high-speed wet granulator (cutter speed 800 rpm, stirring paddle speed 300 rpm), and passed through a 20-mesh screen.

[0034] Drying: Place the wet granules in a hot air circulation oven at 50°C and dry until the moisture content of the granules is 2.5%.

[0035] Granulation: Pass the dried granules through a 20-mesh sieve.

[0036] Total mixing: Add magnesium stearate, micro-powdered silica gel, mogroside and emblica essence to the granules after granulation, and mix in a mixer for 10 minutes until uniform.

[0037] Tablet pressing: Use a rotary tablet press, set the tablet weight to 1.2 g / tablet, control the hardness at 6-8 kg, and press into oval tablets.

[0038] Packaging: After tableting, bottle (with desiccant added).

[0039] Example 3: Comparative Verification of Process Parameters (Based on the Formula of Example 1) This example aims to illustrate the effect of a key process parameter (drying temperature) on the retention of the active ingredient.

[0040] Recipe: Same as Example 1.

[0041] Preparation method (steps 1-4): Same as Example 1.

[0042] Dry (Comparative): Group A (present invention): fluidized bed drying, air inlet temperature 55°C, dried to a moisture content of 3.0%.

[0043] Group B (control group): fluidized bed drying, inlet air temperature 70°C, dried to a moisture content of 3.0%.

[0044] Subsequent steps (granulation, mixing, tableting): Same as Example 1.

[0045] Detection: The dried granules of Group A and Group B were sampled separately.

[0046] Measurement indicators: Vitamin C retention rate in Phyllanthus emblica extract and puerarin retention rate in Pueraria lobata extract.

[0047] Results (example): Group A (55°C): Vitamin C retention rate >95%, puerarin retention rate >98%.

[0048] Group B (70°C): Vitamin C retention rate was 75%, and puerarin retention rate was 92%.

[0049] Conclusion: Excessively high drying temperatures (70°C) can significantly degrade heat-sensitive ingredients, particularly vitamin C. The present invention uses a drying temperature of ≤60°C (preferably 50-55°C) to effectively protect the active ingredients.

[0050] Example 4: Effect Verification (Animal Experiment Example) Objective: To preliminarily verify the protective effect of the compressed candy prepared in Example 2 on acute alcoholic liver injury.

[0051] Animal model: Healthy male mice were randomly divided into: Normal control group: gavage with normal saline.

[0052] Model control group: 50% ethanol was administered orally (to establish liver damage).

[0053] The present invention group: the compressed candy powder of Example 2 (converted into an appropriate dose based on the active ingredient) was administered 1 hour before oral administration of 50% ethanol.

[0054] Positive control group: A commercially available liver-protecting drug (such as bifendate) was administered 1 hour before oral administration of 50% ethanol.

[0055] Index detection: A certain period of time after the last treatment (e.g. 12 hours), blood and liver samples were collected.

[0056] Serum: alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels (markers of liver damage).

[0057] Liver: superoxide dismutase (SOD) activity and malondialdehyde (MDA) content (oxidative stress indicators); HE staining was used to observe liver pathological changes.

[0058] Expected Results: Compared with the model control group, the serum ALT and AST levels of mice in the present invention group were significantly reduced; SOD activity in the liver was increased, and MDA content was reduced; and pathological damage to liver tissue (such as fatty degeneration and inflammatory infiltration) was significantly alleviated. The effect may be better than or equivalent to that of the positive control group.

[0059] Conclusion: The compressed candy of the present invention can effectively alleviate acute liver injury induced by alcohol, and its mechanism may be related to the reduction of oxidative stress.

[0060] The present invention uses Phyllanthus emblica and Pueraria root, which are both medicinal and edible, as the core, and is made into compressed candies through scientific proportioning and low-temperature technology. The candies have the dual effects of accelerating hangover relief and protecting the liver, and are natural, safe, pleasant in taste, and convenient to eat.

[0061] The above description is merely one embodiment of the present invention and is not intended to limit the present invention. Those skilled in the art will readily appreciate that the present invention is susceptible to various modifications and variations. Any modifications, equivalent substitutions, or improvements made within the spirit and principles of the present invention shall be included within the scope of protection of the present invention.

Claims

1. A candy for relieving alcohol and protecting liver with Phyllanthus emblica and Pueraria root tablets, characterized in that: The invention comprises the following components by weight: 20% - 40% of emblica extract, 15% - 30% of kudzu root extract, 30% - 60% of filler, 2% - 5% of binder and 0.5% - 2% of lubricant.

2. The alcohol-relieving and liver-protecting emblica bud and kudzu root tablet candy according to claim 1, characterized in that: Optionally, the invention further comprises one or more components selected from the following group: 5%-15% of Hovenia dulcis fruit extract, 1%-5% of curcumin, vitamin B1, vitamin B6 and glutathione precursor.

3. The alcohol-relieving and liver-protecting emblica bud and kudzu root tablet candy according to claim 2, characterized in that: The polyphenol content in the emblica extract is ≥ 40%, and the vitamin C content is ≥ 20%.

4. The alcohol-relieving and liver-protecting emblica bud and kudzu root tablet candy according to claim 3, characterized in that: The puerarin content in the kudzu root extract is ≥ 30%.

5. The alcohol-relieving and liver-protecting emblica bud and kudzu root tablet candy according to claim 4, characterized in that: The filler is selected from one or more of sorbitol, maltitol, xylitol, erythritol, microcrystalline cellulose, and pregelatinized starch.

6. The alcohol-relieving and liver-protecting emblica bud and kudzu root tablet candy according to claim 5, characterized in that: The adhesive is selected from one or more of hydroxypropyl methylcellulose (HPMC), polyvinyl pyrrolidone (PVP), and starch slurry.

7. The alcohol-relieving and liver-protecting emblica bud and kudzu root tablet candy according to claim 6, characterized in that: The lubricant is selected from one or more of magnesium stearate, micro powder silica gel and talc.

8. A method for preparing the alcohol-relieving and liver-protecting emblica bud and kudzu root tablet candy according to any one of claims 1 to 8, characterized in that: The following steps are involved: (1) Pretreatment: sieve the emblica extract, kudzu root extract, and filler for later use; (2) Premixing: put the emblica extract, kudzu root extract, filler, and other optional active ingredients sieved in step (1) into a mixer and mix them evenly; (3) Making a soft material: add a binder solution to the premixed powder obtained in step (2) to make a soft material; (4) Granulation: make the soft material obtained in step (3) into granules; (5) Drying: dry the wet granules obtained in step (4) at ≤60°C to a moisture content of 2%-4%; (6) Granulation: sieve the dried granules obtained in step (5) for granulation; (7) Total mixing: add a lubricant and a flavoring agent to the granules obtained in step (6) and mix them evenly; (8) Tableting: press the mixed granules obtained in step (7) into tablets.