A method for preparing a benzofuranone derivative
CN120717979BActive Publication Date: 2026-06-19TAIZHOU POLYTECHNIC COLLEGE +1
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Patent Information
- Application Number
- CN202510903881.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-01
- Publication Date
- 2026-06-19
- Estimated Expiration
- 2045-07-01
AI Technical Summary
Technical Problem
In the existing technology, the yield of trans-isomerized benzofuranone derivatives is low, and the preparation process needs to be adjusted to obtain more trans isomers.
Method used
A hindered Lewis acid-base pair was used as a catalyst. Compound I and Compound II were reacted in a solvent, and the catalyst was prepared using zinc oxide and stannous chloride. The reaction conditions were adjusted to improve the yield of the trans isomer.
Benefits of technology
It significantly improved the yield of trans isomers, reduced the amount of expensive catalysts used, lowered costs, and optimized the selectivity of trans configurations through spatial structure and acid-base interactions, thereby improving product purity and catalytic efficiency.
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Abstract
This invention belongs to the field of organic compound preparation, specifically relating to a method for preparing benzofuranone derivatives. Compound I, compound II, and a hindered Lewis acid-base pair catalyst are mixed in a solvent and reacted at 55-75°C for 1.5-3 hours; the products are separated after the reaction is complete. The method of this invention can improve the yield of the trans isomer, and the reaction conditions are more controllable. The catalyst selectivity is strong, and the yield is significantly improved compared to using zinc oxide or stannous chloride alone.
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