Synthesis method of (2S, 5R)-5-[(phenylmethoxy) amino]-2-piperidine carboxylic acid ethyl ester oxalate
CN120794902APending Publication Date: 2025-10-17QINGDAO HUASHANG XINYAO PHARMACEUTICAL TECHNOLOGY CO LTD
Patent Information
- Application Number
- CN202510921046.5
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-07-04
- Publication Date
- 2025-10-17
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Figure CN120794902A_ABST
Abstract
The invention discloses a synthesis method of (2S, 5R)-5-[(phenyl methoxy) amino]-2-piperidine carboxylic acid ethyl ester oxalate. L-Boc ethyl pyroglutamate is used as a starting material, and the (2S, 5R)-5-[(phenyl methoxy) amino]-2-piperidine carboxylic acid ethyl ester oxalate is obtained through five chemical reactions of ring opening recarburization, ring closing, asymmetric catalytic hydrogenation, nucleophilic substitution and acidolysis deprotection, one-step salification and recrystallization. Compared with the prior art, the synthesis method of the (2S, 5R)-5-[(phenylmethoxy) amino]-2-piperidine carboxylic acid ethyl ester oxalate has the advantages that the initial raw materials are cheap, the reaction post-treatment difficulty in the synthesis step is low, the chiral selectivity is good, and the like.
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Citation Information
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