Injectable ultrasonic response piezoelectric and conductive integrated short fiber as well as preparation method and application thereof

Abstract

The invention provides an injectable ultrasonic response piezoelectric and conductive integrated short fiber as well as a preparation method and application thereof, and belongs to the technical field of biomedical materials. According to the invention, an injectable ultrasonic response piezoelectric conductive integrated short fiber network is constructed, the secretion of Schwann cell exosome miRNAs is regionally activated through accurate acoustoelectric conversion for the first time, and the regeneration of nervous functional bones is promoted. According to the invention, accurate control of electricity generation-electricity conduction integration under the ultrasonic action is realized. In-vitro experiments find that the acoustoelectric transformation fiber network can activate bone marrow mesenchymal stem cells to promote osteogenic differentiation related PI3K / Akt and Wnt signal pathways and promote osteogenic differentiation of the bone marrow mesenchymal stem cells by accurately regulating secretion of regional Schwann cell exosomes. In-vivo experiments further prove that the acoustoelectric conversion fiber network can guide short fibers to be injected to a bone injury position under the action of ultrasonic imaging, accurate acoustoelectric conversion and electric signal control are achieved through accurate control over ultrasonic parameters, and formation of a neural network and bone tissue regeneration are remarkably promoted.

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