Protein marker for noninvasive evaluation of embryonic development quality and application thereof
CN120801704APending Publication Date: 2025-10-17PEKING UNIV
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Patent Information
- Application Number
- CN202510857152.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-06-25
- Publication Date
- 2025-10-17
AI Technical Summary
Technical Problem
Existing technologies lack universal and direct protein markers for non-invasive assessment of embryo development quality. Traditional methods rely on embryo appearance assessment or biopsy, which may damage the embryo, and existing proteomic analysis does not clearly indicate specific markers.
Method used
C1rL protein is used as a marker in embryo culture medium, and its concentration changes are detected by ELISA. A non-invasive method for evaluating embryo development quality is established, and a kit is provided for detection.
Benefits of technology
It achieves rapid, non-invasive and accurate assessment of embryo quality, improves pregnancy success rate, is suitable for a variety of populations, and guides the selection and transplantation of high-quality embryos.
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Figure CN120801704A_ABST
Abstract
The invention discloses a protein marker for noninvasive evaluation of embryonic development quality and application thereof, and belongs to the technical field of biological detection. The C1rL protein serves as a key factor in the embryo development process, the development state of an embryo can be indirectly reflected by the concentration change of the C1rL protein in an embryo culture solution, a new way is provided for embryo quality evaluation, and a new thought and scheme are provided for infertility treatment. Based on the protein marker C1rL, the invention provides a method for non-invasively evaluating the embryonic development quality, and rapid and non-invasive evaluation of the embryonic development quality is realized, so that powerful support is provided for optimization of an assisted reproduction technology. The present invention uses C1rL protein as an index to noninvasively and simply determine blastocyst quality, and further selects a high-quality embryo for transplantation to improve pregnancy rate.
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