Novel liver delivery antiviral prodrug crystal form and preparation method and application thereof
By developing antiviral prodrug crystals with liver-specific delivery capabilities, the problems of low bioavailability and high toxicity of existing drugs in hepatocytes have been solved, achieving efficient liver-targeted delivery and low-toxicity therapeutic effects.
CN120865293APending Publication Date: 2025-10-31ZHEJIANG PALOALTO PHARMA TECH CO LTD
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Patent Information
- Application Number
- CN202410529684.8
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-29
- Publication Date
- 2025-10-31
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Figure CN120865293A_ABST
Abstract
The invention discloses a novel liver delivery antiviral prodrug crystal form and a preparation method and application thereof. Specifically, the invention provides a crystal form of 2-amino-9-((1S, 3R, 4S)-3-((((2S, 4R)-4-(5-chloro-2-fluorophenyl)-2-oxide-1, 3, 2-dioxane hetero-phosphinane) oxy) methyl)-4-hydroxy-2-methylene cyclopentyl)-1H-purine-6 (9H)-ketone as shown in a formula (I) as well as a preparation method and application of the crystal form. The crystal form disclosed by the invention has the characteristics of remarkable drug effect, good stability, high yield, high purity and the like, and can be used for preparing drugs for treating or preventing acute or chronic diseases related to hepatitis B virus infection.
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