Process for the resolution of dl-aminopropanol to produce l-aminopropanol

By leveraging the synergistic effect of immobilized CALB lipase and Ru-WC/NH2-SiO2 catalyst, efficient resolution of DL-aminopropanol was achieved, yielding L-aminopropanol with high yield and high purity, thus solving the economic and purity issues of existing resolution methods.

CN120866435BActive Publication Date: 2026-07-14SHANDONG DIAM CHEM CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANDONG DIAM CHEM CO LTD
Filing Date
2025-07-21
Publication Date
2026-07-14

AI Technical Summary

Technical Problem

Existing technologies lack an economically feasible method to resolve racemic DL-aminopropanol to prepare high-purity L-aminopropanol. Chiral raw materials and reducing agents are expensive, and D-aminopropanol is difficult to control effectively in the synthesis process.

Method used

An immobilized CALB lipase and a bimetallic catalyst Ru-WC/NH2-SiO2 were used to prepare a catalyst through physical adsorption and chemical modification. This catalyst was then combined with esterification and hydrolysis purification to achieve efficient resolution of DL-aminopropanol.

Benefits of technology

The preparation of L-aminopropanol with high yield and high purity was achieved. The racemization rate of the D-isomer was higher than that of esterification, ensuring that the D-type did not accumulate. The catalyst had good stability, and the preparation process was economical and practical.

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Abstract

The application belongs to the technical field of fine chemical industry, and particularly relates to a method for preparing L-amino propanol by resolving DL-amino propanol. The resolving method comprises the following steps: (1) preparing immobilized CALB lipase; (2) preparing a bimetallic catalyst; (3) performing an ester exchange reaction with vinyl acetate under the action of the bimetallic catalyst and the immobilized CALB lipase; and (4) performing an alkaline hydrolysis reaction with sodium hydroxide, and then performing post-treatment to obtain L-amino propanol. The method for preparing L-amino propanol by resolving DL-amino propanol has a synergistic effect between the steps, so that the prepared L-amino propanol has a high yield and purity.
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