Multi-effect repair type toothpaste containing lucid ganoderma extract and preparation method of multi-effect repair type toothpaste

Abstract

The invention discloses a multi-effect repairing type toothpaste which is prepared by taking a ganoderma lucidum extract, nano-hydroxyapatite and lactobacillus plantarum as core components through supercritical extraction, nano-dispersion and low-temperature compounding processes. The toothpaste has the functions of tooth restoration, gingiva care and micro-ecological regulation, and the raw materials are natural and safe, so that the toothpaste is suitable for sensitive people. Clinical data prove that the tooth enamel hardness is remarkably improved, gingival bleeding is reduced, and the village revitalizing linkage benefit is achieved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of daily chemical products, in particular to a toothpaste with traditional Chinese medicine extract as the core component, combined with nanomaterials and probiotics, having the effects of repairing teeth, balancing oral microecology and multiple care, and a preparation method thereof. BACKGROUND

[0002] Existing toothpastes mainly focus on single function (such as anti-caries or whitening), and traditional repair ingredients (such as fluoride) have potential toxicity risks. The application of medicinal plants such as Ganoderma lucidum in oral care has not been fully developed, and the repair effect of nano-hydroxyapatite (nHAP) is limited by its synergy with other active ingredients. In addition, there is a lack of natural solutions to problems such as bad breath and ulcers caused by imbalance of oral microecology. SUMMARY

[0003] The present application aims to solve the following problems: single function of existing toothpastes, which cannot simultaneously achieve tooth repair, gum care and oral microecology balance; potential toxicity risks of chemically synthesized ingredients (such as fluoride); synergy stability problems of natural active ingredients (such as Ganoderma lucidum extract) and nanomaterials (such as nHAP); low survival rate of oral probiotics in toothpaste, making it difficult to play a long-term regulating role.

[0004] The present application provides a multi-effect repair type toothpaste, the core formula and preparation method of which are as follows: Ganoderma lucidum extract: selected from the "Jingzhi No. 1" strain in the base supported by Zhejiang University in Jingdong Yi Autonomous County, Pu'er City, Yunnan Province, with polysaccharide content ≥4.69% and triterpenoid content ≥22.7%, having the effects of enhancing gum immunity and anti-inflammatory; nano-hydroxyapatite (nHAP): particle size ≤100 nm, accounting for 1-10%, used for repairing enamel micro-defects; Lactobacillus plantarum: freeze-dried powder with viable bacteria count ≥1×10^8 / g, accounting for 0.1-1%, used for regulating oral flora balance; synergistic traditional Chinese medicine formula: including propolis, honeysuckle flower, forsythia, white and licorice extract, respectively playing the roles of antibacterial, hemostatic, promoting mucosal repair, etc.

[0005] Preparation method. Traditional Chinese medicine extract pretreatment: supercritical carbon dioxide extraction technology is used to extract active ingredients of traditional Chinese medicines such as Ganoderma lucidum and propolis, retaining their natural effects; nano-hydroxyapatite dispersion: nHAP is mixed with glycerol at a ratio of 1:5, ultrasonic dispersion for 30 minutes to form a stable suspension; probiotic mixing: Lactobacillus plantarum freeze-dried powder is reconstituted in a low-temperature environment below 40℃ to avoid high-temperature damage to activity; matrix preparation and total mixing: homogenously stirring the matrix ingredients such as hydrated silicon stone and sodium carboxymethyl cellulose with active ingredients for 2 hours; filling and sterilization: vacuum filling process is used, low-temperature (≤50℃) sterilization for 30 minutes to ensure the survival rate of probiotics.

[0006] Benefits. Multifunctional integration: simultaneously achieve tooth repair, gum care, oral microecological balance, and breath freshening; natural safety: core ingredients derived from natural plants or food-grade raw materials, no chemical hormones, suitable for sensitive groups; efficient repair: clinical tests show that after 28 days of use, enamel hardness increases by 30%, and gum bleeding index decreases by 65%; social benefits: raw materials come from rural revitalization projects, combining industrial innovation and social responsibility. BRIEF DESCRIPTION OF DRAWINGS Figure 1 is a physical photo of the toothpaste product of the present application.

Claims

1. A toothpaste, characterized by It contains 0.5-5% red mushroom extract (polysaccharide ≥4.69%, triterpene ≥22.7%), 1-10% nano hydroxyapatite (particle size ≤100 nm), 0.1-1% lactobacillus plantarum (CFU ≥1×10^8 / g), and a combination of propolis, honeysuckle flower, white and other traditional Chinese medicine extracts.

2. The method of claim 1, comprising: Supercritical carbon dioxide extraction of active ingredients of traditional Chinese medicine; Ultrasonic dispersion process of nHAP and glycerol; Preparation of probiotics and traditional Chinese medicine components under low temperature environment.

3. The toothpaste is used in the prevention of dental caries, repair of enamel, and treatment of oral ulcers.

Images