Polydopamine nano anti-tumor therapeutic agent loaded with magnesium ions and metformin as well as preparation method and application of polydopamine nano anti-tumor therapeutic agent

By using polydopamine nanoparticles loaded with magnesium ions and metformin, combined with photothermal and immunotherapy, the problems of biosafety and drug delivery efficiency of existing nano-drug delivery systems have been solved, achieving efficient enrichment and immune modulation at tumor sites and promoting synergistic effects in tumor treatment.

CN120899902APending Publication Date: 2025-11-07赣州市人民医院
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Patent Information

Application Number
CN202510901058.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2025-07-01
Publication Date
2025-11-07

AI Technical Summary

Technical Problem

Existing nanomedicine delivery systems have unclear biosafety in tumor treatment, low drug delivery efficiency, insufficient enrichment at tumor sites, single immune regulation mechanism, and lack of synergistic effect. Most existing nanomedicine delivery systems are single-function and lack synergistic design of therapy-immune regulation.

Method used

By loading divalent magnesium ions and metformin onto polydopamine nanoparticles and combining photothermal therapy with immunotherapy, a synergistic immune effect is achieved through magnesium ion-induced immunotherapy and polydopamine-induced enhanced photothermal therapy, thus preparing a Met@PDA@Mg2+ antitumor therapeutic agent.

Benefits of technology

It can efficiently accumulate in tumor sites, enabling precise targeted drug delivery, promoting the proliferation and activation of dendritic cells and cytotoxic T lymphocytes, regulating the immune microenvironment, and exhibiting good biosafety and synergistic anti-tumor effects.

✦ Generated by Eureka AI based on patent content.

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Abstract

The invention belongs to the technical field of biological medicines, discloses a magnesium ion and metformin loaded polydopamine nano anti-tumor therapeutic agent as well as a preparation method and application thereof, and particularly discloses an anti-tumor therapeutic agent which comprises polydopamine and a medicine loaded on the polydopamine, comprising polydopamine and a drug loaded on the polydopamine, the drug comprises a divalent magnesium ion compound, and the divalent magnesium ion compound is loaded in the polydopamine. The anti-tumor therapeutic agent (Meet (at) PDA (at) Mg < 2 + > is prepared by taking polydopamine as a carrier and loading (such as metformin and magnesium ions), and the anti-tumor therapeutic agent has the effects of enhancing permeation and retention, is high in enrichment degree at a tumor part, and can be decomposed in a tumor acidic microenvironment so as to release drugs. Meanwhile, the anti-tumor therapeutic agent combines photo-thermal therapy and immunotherapy and has a synergistic anti-tumor effect, so that the aim of targeted therapy of tumors is achieved.
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