Nanometer preparation capable of performing fluorescence and nuclide bimodal imaging and preparation method thereof

Abstract

The invention relates to the technical field of biochemistry, in particular to a nano preparation capable of performing fluorescence and nuclide bimodal imaging and a preparation method of the nano preparation. The nano preparation is prepared by self-assembly of phospholipid, an apolipoprotein A1 mimic peptide (22A), a near-infrared two-region (NIR-II) fluorescent dye and a functionalized phospholipid-polyethylene glycol conjugate, and is characterized in that the nano preparation is prepared by self-assembly of the phospholipid, the apolipoprotein A1 mimic peptide (22A), the near-infrared two-region (NIR-II) fluorescent dye and the functionalized phospholipid-polyethylene glycol conjugate; wherein the functionalized phospholipid-polyethylene glycol conjugate comprises a functionalized terminal group, and the functionalized terminal group has a function of being combined with radionuclide; the average particle size of the nano preparation is 8-10 nm. After being injected through caudal vein, the nano preparation can be retained at a tumor part to realize fluorescence imaging and nuclide imaging at the same time.

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