Preparation method of L-ornithine hydrochloride

Abstract

The invention provides a preparation method of L-ornithine hydrochloride. The preparation method comprises the following steps: step 1, crude preparation of L-ornithine hydrochloride; step 2, preparing a barium ion removing agent; step 3, separation and purification; step 4, concentration; and step 5, refining the L-ornithine hydrochloride. According to the preparation method provided by the invention, low-cost L-arginine hydrochloride and barium hydroxide are used as reaction raw materials, the purity of the product is ensured by controlling the temperature, and the yield and the stability are improved by tracking the reaction process through HPLC (High Performance Liquid Chromatography); carbonate is used as a barium removal agent during barium removal, operation is easy and convenient, the equipment requirement is low, and the separation effect is excellent; ammonia type cationic resin column passing treatment and concentration are subsequently adopted, high-temperature degradation can be prevented by adjusting to be acidic, and then the product quality and yield are improved by combining decoloration and crystallization; finally, the ammonium ion content is strictly controlled through ethanol pulping, it is ensured that the product meets the quality standard of the amino acid raw material medicine, the process is easy and convenient to operate, and the production efficiency and the product quality are remarkably improved.