一种化合物及其制备方法与用途
By modifying the structure of reboxil, a new crystalline form was prepared, which solved the problems of low solubility and hygroscopicity of reboxil, achieved high permeability and good bioavailability, simplified formulation development, and improved drug stability and storage conditions.
CN120904207BActive Publication Date: 2026-07-17ANHUI IPCKE PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ANHUI IPCKE PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO LTD
- Filing Date
- 2025-09-12
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
The existing anhydrous form of reboxil has low solubility and moderate permeability, resulting in insufficient bioavailability. In addition, its high hygroscopicity and strict storage requirements limit its clinical application.
Method used
By modifying the structure of ripocidide, a new crystalline form was prepared. This crystal is stable under specific solvent and conditions, has high permeability and non-efflux transport characteristics, avoids hygroscopicity, and improves oral bioavailability and storage stability.
Benefits of technology
This approach achieves high permeability and good bioavailability of reboxil crystals, simplifies formulation development, reduces storage requirements, and improves drug stability and pharmaceutical performance.
✦ Generated by Eureka AI based on patent content.
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Figure CN120904207B_ABST
Abstract
本发明提供了式(Ⅰ)所示的化合物或其溶剂化物、水合物及其药学上可接受的盐、其晶型、其制备方法、其制备治疗乳腺癌药物中的用途。该化合物具有良好的稳定性和口服吸收性，具有理想的药代动力学特征和良好的药物开发前景。
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