一种三重超分子美白组合物及其制备方法和应用
By encapsulating nicotinamide, ferulic acid, and glycyrrhizin with cyclodextrin to form a triple supramolecular whitening composition, the phase separation problem caused by the differences in the physicochemical properties of whitening ingredients is solved, achieving high loading efficiency, improved stability, and transdermal synergistic effect, making it suitable for various cosmetic formulations.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- BEIJING SHANGJIE YOULAN TECH CO LTD
- Filing Date
- 2025-09-02
- Publication Date
- 2026-07-17
AI Technical Summary
Existing skin-whitening ingredients such as niacinamide, ferulic acid, and glycyrrhizin have significant differences in physicochemical properties. Direct physical mixing can easily lead to phase separation, making it difficult to achieve synergistic effects. Furthermore, the dissolution problem of glycyrrhizin has not been solved, and traditional supramolecular carrier systems have insufficient drug loading efficiency, making it impossible to achieve multi-component synergistic drug loading and sustained release.
Cyclodextrin was used as a carrier. After dissolving glycyrrhizin with a solubilizer, it was encapsulated stepwise with ferulic acid and nicotinamide to form a triple supramolecular whitening composition. Ferulic acid was used as a bridging ligand. The inclusion conflict was resolved by matching size and polarity, and a stable ternary complex was formed by dynamic bridging, which synergistically enhanced the whitening effect.
It improves the solubility and stability of the three active ingredients, achieves transdermal sustained release, enhances the whitening effect, improves bioavailability, and is suitable for conventional cosmetic formulations such as water, cream, and lotion.
Smart Images
Figure CN120938853B_ABST