Natural plant hair care agent with scalp repairing and hair loss preventing effects

Abstract

The invention relates to a natural plant hair conditioner with scalp repairing and hair loss preventing effects, and belongs to the technical field of daily chemicals. The composition comprises the following components in parts by mass: 11-38 parts of a composite plant extract, 5-15 parts of a humectant, 0.5-2 parts of a thickening agent, 0.1-1 part of a pH regulator, 0.1-0.5 part of a preservative and the balance of deionized water, totaling 100 parts. The compound plant extract is prepared from South African drunken solanum, red clover, rhizoma picrorhizae and argania spinosa extracts according to the mass ratio of (5-15): (3-10): (2-8): (1-5) through specific compound strain fermentation. According to the hair conditioner, the molecular weight of the extract is homogenized through a scientific proportioning and fermentation process, a stable system is formed, and the hair conditioner has excellent storage and illumination stability, is remarkable in scalp repairing and hair loss preventing effects and is suitable for preparing related products.

Description

Technical Field

[0001] This invention belongs to the field of daily chemical products, specifically relating to a natural plant-based hair conditioner with scalp repair and anti-hair loss effects. Background Technology

[0002] With the fast pace of life, increased mental stress, and environmental pollution, hair loss and scalp problems are increasingly becoming common issues troubling people. Statistics show that approximately 40% of men and 20% of women worldwide suffer from varying degrees of hair loss, while scalp inflammation, sebum imbalance, and impaired scalp barrier function are also prevalent.

[0003] Currently, the market offers a wide variety of hair care products targeting hair loss and scalp problems, mainly including chemically synthesized drugs, hormone-based products, and natural plant-based products. Chemically synthesized drug products, such as minoxidil and finasteride, while having some anti-hair loss effects, may have side effects such as scalp irritation and allergic reactions, and long-term use may pose potential health risks. Hormonal products, although faster-acting, are prone to causing hormone dependence, with significant rebound effects after discontinuation, and may also trigger endocrine disorders.

[0004] Natural plant-based hair care products are increasingly favored by consumers due to their relatively mild nature and fewer side effects. However, existing natural plant-based hair care products still have many shortcomings: most products use plant extracts such as ginger, which, while having certain effects, can easily lead to tolerance with long-term use, and their mechanism of action is relatively simple, making it difficult to comprehensively address scalp repair and hair loss prevention; commonly used traditional extraction methods such as decoction and alcohol extraction have low extraction efficiency, resulting in significant loss of effective ingredients, and the uneven molecular weight distribution of the extracts makes it difficult to form a stable system with other ingredients, leading to poor product storage and light stability; the lack of scientific ingredient combinations and ratios makes it difficult for the various ingredients to produce synergistic effects, affecting the overall efficacy of the product; due to the complexity of natural ingredients, existing products are prone to layering, precipitation, and discoloration during storage, and are more susceptible to oxidation and deterioration under light conditions, affecting the product's effectiveness and shelf life.

[0005] Therefore, developing a hair conditioner with natural ingredients, a scientifically formulated recipe, good stability, and significant scalp repair and anti-hair loss effects has become a pressing technical problem to be solved in this field. Summary of the Invention

[0006] The purpose of this invention is to provide a natural plant-based hair conditioner with scalp repair and anti-hair loss effects. It achieves molecular weight homogenization of the extracts through fermentation with four plant extracts and a specific complex strain of bacteria, forming a stable system that combines excellent storage stability, light stability, and scalp repair and anti-hair loss effects.

[0007] The objective of this invention can be achieved through the following technical solutions:

[0008] A natural plant-based hair conditioner with scalp repair and anti-hair loss effects, the composition comprising, by weight:

[0009] 11-38 parts of compound plant extract

[0010] 5-15 parts moisturizer

[0011] Thickener 0.5-2 parts

[0012] pH adjuster 0.1-1 part

[0013] Preservative 0.1-0.5 parts

[0014] Add deionized water to bring the total to 100 parts;

[0015] The compound plant extract is composed of Ashwagandha extract, Red Clover extract, Picrorhiza kurroa extract and Argania serratifolia extract in a mass ratio of (5-15):(3-10):(2-8):(1-5).

[0016] As a preferred embodiment of the present invention, the Ashwagandha extract, Red Clover extract, Picrorhiza scrophulariiflora extract, and Argania serratifolia extract are all prepared by the following methods:

[0017] The plant materials are ground and mixed with 5-10 times the amount of deionized water, then inoculated with a compound microbial culture at 10% of the total mass. The mixture is then fermented and centrifuged and filtered to obtain the extract.

[0018] As a preferred embodiment of the present invention, the composite bacterial strain consists of 1.0 × 10⁻⁶ microorganisms. 8 CFU / mL Lactobacillus bulgaricus, 1.5×10 8 Lactobacillus acidophilus CFU / mL, 1.2×10 8 CFU / mL of Bifidobacteria and 0.8×10 8 Composition of Lactobacillus plantarum CFU / mL.

[0019] As a preferred embodiment of the present invention, the moisturizer is composed of glycerin and propylene glycol in a mass ratio of 2:1.

[0020] In a preferred embodiment of the present invention, the thickener is xanthan gum.

[0021] As a preferred embodiment of the present invention, the pH adjuster is a citric acid-sodium citrate buffer solution.

[0022] In a preferred embodiment of the present invention, the preservative is phenoxyethanol.

[0023] As a preferred embodiment of the present invention, the fermentation temperature of the extract is 35-40℃, the fermentation time is 48-72 hours, and the centrifugation speed is 4000 rpm.

[0024] A method for preparing the above-mentioned hair conditioner includes the following steps:

[0025] W1. Preparation of compound plant extracts;

[0026] W2. Heat deionized water, add humectant and thickener to dissolve, cool and then add extract;

[0027] W3. Add pH adjuster to adjust pH to 5.5-6.5;

[0028] W4. Add preservatives and filter to obtain the hair conditioner.

[0029] Application of the above-mentioned hair conditioner in the preparation of anti-hair loss and scalp repair products

[0030] This is a preferred technical solution of the present invention.

[0031] The beneficial effects of this invention are:

[0032] (1) It uses all-natural plant ingredients such as Ashwagandha extract, Red Clover extract, Picrorhiza scrophulariiflora extract, and Argania serratifolia extract, which are highly safe.

[0033] (2) After fermentation by compound bacteria, the four extracts have uniform molecular weight and can work together to achieve anti-inflammatory, hormone regulation, antibacterial and nourishing effects, thereby improving the scalp environment from the root.

[0034] (3) The fermentation of compound microorganisms concentrates the molecular weight distribution of the extract and forms a stable system with other components, resulting in a high retention rate of effective components.

[0035] (4) It has a significant effect on improving various types of hair loss, such as seborrheic alopecia and alopecia areata, as well as sensitive scalps. Detailed Implementation

[0036] To further illustrate the technical means and effects of the present invention in achieving its intended purpose, the following detailed description of the specific implementation methods, structures, features, and effects of the present invention, in conjunction with embodiments, is provided below.

[0037] Example 1

[0038] 10 parts of Ashwagandha extract from South Africa;

[0039] Six parts of red clover extract;

[0040] Five parts of Coptis chinensis extract;

[0041] Three parts of Argan Tree Extract;

[0042] 8 parts glycerin;

[0043] 4 parts propylene glycol;

[0044] 1 part xanthan gum;

[0045] Citric acid-sodium citrate buffer (pH=6.0) 0.5 parts;

[0046] 0.3 parts of phenoxyethanol;

[0047] Add deionized water to bring the total to 100 parts.

[0048] Preparation method:

[0049] 1. Preparation of plant extracts: After grinding the raw materials, add 8 times the amount of deionized water, and inoculate with 1.0×10⁻⁶ mol / L at 10% of the total mass. 8 CFU / mL Lactobacillus bulgaricus, 1.5×10 8 Lactobacillus acidophilus CFU / mL, 1.2×10 8 CFU / mL of Bifidobacteria and 0.8×10 8 A complex strain composed of Lactobacillus plantarum at CFU / mL was fermented at 35℃ for 72 hours, centrifuged at 4000 rpm for 15 minutes, and filtered through a 0.22 μm filter membrane.

[0050] 2. Heat deionized water to 65°C, add glycerin, propylene glycol, and xanthan gum to dissolve, cool to 45°C, and add the four extracts;

[0051] 3. Adjust the pH to 6.0, add phenoxyethanol, filter through a 0.45μm filter membrane to obtain the hair conditioner.

[0052] Example 2

[0053] 15 parts of Ashwagandha extract from South Africa;

[0054] Three parts of red clover extract;

[0055] Eight parts of Coptis chinensis extract;

[0056] One part of Argania serratifolia extract;

[0057] 10 parts glycerin;

[0058] 5 parts propylene glycol;

[0059] 0.5 parts xanthan gum;

[0060] Citric acid-sodium citrate buffer solution (pH=5.5) 0.3 parts;

[0061] 0.1 parts of phenoxyethanol;

[0062] Add deionized water to bring the total to 100 parts.

[0063] Preparation method:

[0064] 1. Preparation of plant extracts: After grinding the raw materials, add 5 times the amount of deionized water, and inoculate with 1.0×10⁻⁶ mol / L of the extract at 10% of the total mass. 8 CFU / mL Lactobacillus bulgaricus, 1.5×10 8 Lactobacillus acidophilus CFU / mL, 1.2×10 8 CFU / mL of Bifidobacteria and 0.8×10 8 A complex strain composed of Lactobacillus plantarum at CFU / mL was fermented at 37℃ for 60 hours, centrifuged at 4000rpm for 15 minutes, and filtered through a 0.22μm filter membrane.

[0065] 2. Heat deionized water to 65°C, add glycerin, propylene glycol, and xanthan gum to dissolve, cool to 45°C, and add the four extracts;

[0066] 3. Adjust the pH to 5.5, add phenoxyethanol, filter through a 0.45μm filter membrane to obtain the hair conditioner.

[0067] Example 3

[0068] Five parts of Ashwagandha extract from South Africa;

[0069] 10 parts of red clover extract;

[0070] Two portions of Coptis chinensis extract;

[0071] 5 parts of Aralia elata extract;

[0072] 6 parts glycerin;

[0073] 3 parts propylene glycol;

[0074] 2 parts xanthan gum;

[0075] Citric acid-sodium citrate buffer (pH=6.5) 1 part;

[0076] 0.5 parts of phenoxyethanol;

[0077] Add deionized water to bring the total to 100 parts.

[0078] Preparation method:

[0079] 1. Preparation of plant extracts: After grinding the raw materials, add 10 times the amount of deionized water, and inoculate with 1.0×10⁻⁶ mol / L of the extract at 10% of the total mass. 8 CFU / mL Lactobacillus bulgaricus, 1.5×10 8 Lactobacillus acidophilus CFU / mL, 1.2×10 8 CFU / mL of Bifidobacteria and 0.8×108 A complex strain composed of Lactobacillus plantarum at CFU / mL was fermented at 40℃ for 48 hours, centrifuged at 4000rpm for 15 minutes, and filtered through a 0.22μm filter membrane.

[0080] 2. Heat deionized water to 65°C, add glycerin, propylene glycol, and xanthan gum to dissolve, cool to 45°C, and add the four extracts;

[0081] 3. Adjust the pH to 6.5, add phenoxyethanol, filter through a 0.45μm filter membrane to obtain the hair conditioner.

[0082] Comparative Example 1

[0083] 10 parts of red clover extract;

[0084] Eight parts of Coptis chinensis extract;

[0085] Six parts of Argania serratifolia extract;

[0086] 8 parts glycerin;

[0087] 4 parts propylene glycol;

[0088] 1 part xanthan gum;

[0089] Citric acid-sodium citrate buffer (pH=6.0) 0.5 parts;

[0090] 0.3 parts of phenoxyethanol;

[0091] Add deionized water to bring the total to 100 parts.

[0092] Preparation method:

[0093] Same as Example 1, except that the Ashwagandha extract from South Africa is omitted.

[0094] Comparative Example 2

[0095] 12 parts of Ashwagandha extract from South Africa;

[0096] 7 parts of Coptis chinensis extract;

[0097] 5 parts of Aralia elata extract;

[0098] 8 parts glycerin;

[0099] 4 parts propylene glycol;

[0100] 1 part xanthan gum;

[0101] Citric acid-sodium citrate buffer (pH=6.0) 0.5 parts;

[0102] 0.3 parts of phenoxyethanol;

[0103] Add deionized water to bring the total to 100 parts.

[0104] Preparation method:

[0105] Same as Example 1, except that the red clover extract is omitted.

[0106] Comparative Example 3

[0107] 12 parts of Ashwagandha extract from South Africa;

[0108] 8 parts of red clover extract;

[0109] Four parts of Argania serratifolia extract;

[0110] 8 parts glycerin;

[0111] 4 parts propylene glycol;

[0112] 1 part xanthan gum;

[0113] Citric acid-sodium citrate buffer (pH=6.0) 0.5 parts;

[0114] 0.3 parts of phenoxyethanol;

[0115] Add deionized water to bring the total to 100 parts.

[0116] Preparation method:

[0117] Same as Example 1, except that the extract of Coptis chinensis is omitted.

[0118] Comparative Example 4

[0119] 11 parts of Ashwagandha extract from South Africa;

[0120] 7 parts of red clover extract;

[0121] Six parts of Picrorhiza scrophulariiflora extract;

[0122] 8 parts glycerin;

[0123] 4 parts propylene glycol;

[0124] 1 part xanthan gum;

[0125] Citric acid-sodium citrate buffer (pH=6.0) 0.5 parts;

[0126] 0.3 parts of phenoxyethanol;

[0127] Add deionized water to bring the total to 100 parts.

[0128] Preparation method:

[0129] Same as in Example 1, except that the Argan extract is omitted.

[0130] Comparative Example 5

[0131] The *Lactobacillus plantarum* is omitted; otherwise, it is the same as in Example 1.

[0132] Comparative Example 6

[0133] An additional 0.5 × 10⁻⁶ microbial cultures were added. 8 The yeast was CFU / mL, and the rest was the same as in Example 1.

[0134] Comparative Example 7

[0135] The bacterial culture ratio was adjusted to 1:1:1:1, and the rest was the same as in Example 1.

[0136] Comparative Example 8

[0137] The traditional decoction method was used for extraction, which involved adding 8 times the amount of water to the raw material, boiling and extracting for 2 hours, filtering and concentrating, and the remaining steps were the same as in Example 1.

[0138] Comparative Example 9

[0139] Extraction was performed using ethanol extraction, which involved adding 8 times the amount of 70% ethanol to the raw material, refluxing at 60°C for 2 hours, and then removing the ethanol by vacuum concentration. The remaining steps were the same as in Example 1.

[0140] Performance testing

[0141] 1. Stability testing

[0142] ① Storage stability: The sample was stored in a 40℃ constant temperature oven for 3 months. The appearance was observed for phenomena such as layering, precipitation, and discoloration. The changes in the content of effective components (calculated as ashwagandhi lactone in ashwagandhi, genistein in red clover, berberine II in picrocrophularia and vitamin E in argania) were also measured.

[0143] ②Low temperature stability: The sample was frozen in a -20℃ freezer for 24 hours, then thawed at room temperature. This process was repeated 3 times. The appearance changes were observed and the content of the active ingredients was determined.

[0144] ③ Light stability: The sample was placed under strong light of 4000 lx for 10 days, and the appearance changes were observed and the content of effective ingredients was determined.

[0145] 2. Scalp Repair Efficacy Test

[0146] ① In vitro cell experiments: Human scalp keratinocytes (HaCaT cells) were used to induce an inflammation model with lipopolysaccharide (LPS) to detect the effect of hair conditioner on the secretion of inflammatory factors IL-6 and TNF-α. HaCaT cells were seeded in 96-well plates and cultured until 80% confluence. Different concentrations of hair conditioner samples (diluted 10-fold) were added, and an LPS model group and a blank control group were set up. After culturing for 24 hours, the supernatant was collected, and the levels of IL-6 and TNF-α were measured by ELISA.

[0147] ② Barrier function test: Transdermal water loss (TEWL) meter was used to measure the scalp TEWL value of volunteers before and after using hair conditioner to evaluate the improvement of scalp barrier function.

[0148] 3. Anti-hair loss efficacy test

[0149] ① In vitro hair follicle culture experiment: Hair follicles were taken from the back of newborn mice, placed in culture medium, and hair conditioner samples of different concentrations were added. A blank control group was set up. After 7 days of culture, the morphology of hair follicles was observed, the length of hair follicles was measured, and the survival rate of hair follicles was calculated.

[0150] ② Animal experiment: C57BL / 6 mice were selected to establish a hair removal model (hair removal using 8% sodium sulfide solution). The mice were randomly divided into different groups of 10 each. Different samples were applied to each group once a day for 4 consecutive weeks. The hair regeneration was observed, and the hair density, hair diameter and the proportion of hair follicles in the growth phase were calculated.

[0151] Table 1 Stability test results

[0152]

[0153]

[0154] Table 2 Results of scalp repair efficacy test

[0155]

[0156] (Note: Compared with the LPS model group, *P<0.05, **P<0.01)

[0157] Table 3 Results of Anti-hair loss efficacy test

[0158]

[0159] (Note: Compared with the model control group, *P<0.05, **P<0.01)

[0160] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention in any way. Although the present invention has been disclosed above with reference to preferred embodiments, it is not intended to limit the present invention. Any person skilled in the art can make some modifications or alterations to the above-disclosed technical content to create equivalent embodiments without departing from the scope of the present invention. Any simple modifications, equivalent changes and alterations made to the above embodiments based on the technical essence of the present invention without departing from the scope of the present invention shall still fall within the scope of the present invention.

Claims

1. A natural plant-based hair conditioner with scalp repair and anti-hair loss effects, characterized in that, The composition comprises, by weight, parts of: 11-38 parts of compound plant extract 5-15 parts moisturizer Thickener 0.5-2 parts pH adjuster 0.1-1 part Preservative 0.1-0.5 parts Add deionized water to bring the total to 100 parts; The compound plant extract is composed of Ashwagandha extract, Red Clover extract, Picrorhiza kurroa extract and Argania serratifolia extract in a mass ratio of (5-15):(3-10):(2-8):(1-5).

2. The hair conditioner according to claim 1, characterized in that, The extracts of Ashwagandha, Red Clover, Picrorhiza kurroa, and Argania serratifolia were all prepared by the following methods: The plant materials are ground and mixed with 5-10 times the amount of deionized water, then inoculated with a compound microbial culture at 10% of the total mass. The mixture is then fermented and centrifuged and filtered to obtain the extract.

3. A hair conditioner according to claim 2, characterized in that, The compound microbial strain consists of 1.0 × 10⁻⁶ microorganisms. 8 CFU / mL Lactobacillus bulgaricus, 1.5×10 8 Lactobacillus acidophilus CFU / mL, 1.2×10 8 CFU / mL of Bifidobacteria and 0.8×10 8 Composition of Lactobacillus plantarum CFU / mL.

4. A hair conditioner according to claim 1, characterized in that, The moisturizer is composed of glycerin and propylene glycol in a mass ratio of 2:

1.

5. A hair conditioner according to claim 1, characterized in that, The thickener is xanthan gum.

6. A hair conditioner according to claim 1, characterized in that, The pH adjuster is a citrate-sodium citrate buffer solution.

7. A hair conditioner according to claim 1, characterized in that, The preservative is phenoxyethanol.

8. A hair conditioner according to claim 2, characterized in that, The fermentation temperature of the extract is 35-40℃, the fermentation time is 48-72 hours, and the centrifugation speed is 4000 rpm.

9. The method for preparing the hair conditioner according to any one of claims 1-8, characterized in that, Includes the following steps: W1. Preparation of compound plant extracts; W2. Heat deionized water, add humectant and thickener to dissolve, cool and then add extract; W3. Add pH adjuster to adjust pH to 5.5-6.5; W4. Add preservatives and filter to obtain the hair conditioner.

10. The use of a hair conditioner according to any one of claims 1-8 in the preparation of anti-hair loss and scalp repair products.

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