具有持续氧气释放与活性氧清除功能负载干细胞的自交联水凝胶及其应用
By loading stem cells onto self-crosslinking hydrogels and utilizing oxygen release and reactive oxygen species scavenging functions, the problems of short stem cell retention time and functional suppression in the treatment of intrauterine adhesions were solved, thus achieving endometrial regeneration and fertility restoration.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- YIMEI TIMES (SHENZHEN) BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-08-13
- Publication Date
- 2026-07-17
AI Technical Summary
Existing hydrogel carriers are unable to maintain the retention time and function of stem cells in the high ROS and hypoxic environment of the uterine cavity when treating intrauterine adhesions, resulting in poor treatment effects.
A self-crosslinking hydrogel was designed, which was prepared by Schiff base reaction and crosslinked with dopamine-hydrazide modified gelatin and oxidized sodium alginate. Peroxide liposomes and peroxidase were loaded to form a hydrogel with continuous oxygen release and reactive oxygen species scavenging function. Stem cells were then carried to construct a cascade oxygen regeneration mechanism.
It enhances the survival and function of stem cells in the uterine cavity, promotes endometrial regeneration, restores fertility, maintains the role of mechanical barrier and cytokine reservoir for a long time, and significantly improves intrauterine adhesions.
Smart Images
Figure CN120938912B_ABST