相分离多肽及其制备方法和应用
By designing phase-separated peptides, the problem of insufficient sequence diversity and functional complexity of existing peptide aggregates was solved, enabling the enrichment of DNA damage response proteins in cells and enhancing the effect of tumor radiotherapy.
CN120943898BActive Publication Date: 2026-07-17INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCI
- Filing Date
- 2025-08-13
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing peptide aggregates have limited sequence diversity and functional complexity, making it difficult to effectively interfere with DNA damage response mechanisms and affect the sensitivity of tumors to radiotherapy and chemotherapy.
Method used
Phase-separating peptides were designed and synthesized, and through amino acid composition and sequence regulation, condensates were formed that could enrich and separate DNA damage response proteins within cells, thereby interfering with the DNA repair process.
Benefits of technology
It increases the sensitivity of tumor cells to radiotherapy, significantly reduces survival rate, and enhances the effect of radiotherapy.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN120943898B_ABST
Abstract
本发明属于生物医药领域，具体涉及相分离多肽及其制备方法和应用。相分离多肽的结构如式(Ⅰ)所示。本发明提供的多肽化合物，能够发生液‑液相分离形成凝聚体液滴，并在细胞内富集分隔DNA损伤应答蛋白。本发明的多肽化合物，合成方法简单、生物相容性好、可发生液‑液相分离；能够在细胞内捕获DNA损伤应答蛋白，干扰DNA修复，增敏肿瘤放疗效果。因此，本发明的多肽化合物可用于肿瘤放疗、化疗等治疗方法。
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