Oral care composition, application and oral care product

Abstract

The invention belongs to the technical field of oral care, and discloses an oral care composition, application and an oral care product, the oral care composition comprises D-3-hydroxybutyric acid and tetrasodium pyrophosphate, and the mass ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate is 0.001-1: 1. According to the oral care composition provided by the invention, the 3-hydroxybutyric acid and the tetrasodium pyrophosphate are compounded, so that the 3-hydroxybutyric acid and the tetrasodium pyrophosphate also show an excellent tooth whitening effect at a relatively low concentration, and the dosage of the tetrasodium pyrophosphate can be effectively reduced; therefore, the tooth health problem of tooth decalcification caused by long-term use of high-concentration tetrasodium pyrophosphate is avoided.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of oral care, in particular to an oral care composition, use and oral care product. BACKGROUND

[0002] With the emphasis on oral health and aesthetics, the market demand for tooth whitening products is growing. Tooth discoloration is mainly caused by two ways of exogenous pigment deposition and endogenous pigment formation; exogenous pigments mainly come from food, beverages, tobacco, etc., and endogenous pigments are caused by factors such as excessive intake of tetracycline drugs and fluoride. At present, the common whitening toothpaste on the market mainly realizes the effect of tooth whitening through physical friction and chemical removal.

[0003] Among them, the chemical removal method mostly uses tetrasodium pyrophosphate (also known as sodium pyrophosphate), sodium phytate, pentasodium triphosphate (also known as sodium triphosphate), and sodium hexametaphosphate, which have strong calcium ion chelating ability, as the active ingredient for tooth whitening. However, long-term use of these ingredients may cause tooth demineralization, and a high concentration is required in toothpaste to achieve the desired whitening effect, and high concentrations of chemical ingredients may increase the irritation to teeth and oral mucosa; at the same time, the whitening effect of a single component is limited, and it is difficult to meet the needs of consumers for fast and efficient whitening.

[0004] Therefore, it is necessary to study a composition that can efficiently whiten and protect the health of teeth, so as to achieve better tooth whitening effect at low concentration. SUMMARY

[0005] One of the purposes of the present application is to provide an oral care composition that can improve the whitening effect through the synergistic effect of components at low concentration.

[0006] Another purpose of the present application is to provide a use of an oral care composition.

[0007] Meanwhile, the present application also provides an oral care product containing the oral care composition of the present application, which can have the effects of efficient whitening and protection of tooth health.

[0008] To achieve the above purpose, the present application provides an oral care composition comprising D-3-hydroxybutyric acid and tetrasodium pyrophosphate, wherein the mass ratio of the D-3-hydroxybutyric acid and the tetrasodium pyrophosphate is 0.001-1:1.

[0009] Further, the mass ratio of the 3-hydroxybutyric acid and the tetrasodium pyrophosphate is 0.05-0.8:1.

[0010] As a preferred technical solution of the present application, the 3-hydroxybutyric acid is at least one of D-3-hydroxybutyric acid, L-3-hydroxybutyric acid and DL-3-hydroxybutyric acid.

[0011] More preferably, the 3-hydroxybutyric acid is D-3-hydroxybutyric acid.

[0012] The present application also provides a use of the above-mentioned oral care composition for preparing an oral care product.

[0013] The present application further provides an oral care product containing 0.5-2 wt% of the above-mentioned oral care composition.

[0014] The oral care product described in the present application includes oral care products such as toothpaste, mouthwash, oral spray, etc. that can care for teeth; preferably, the oral care product is one of toothpaste, mouthwash and oral spray.

[0015] Advantages Compared with the prior art, the present application provides an oral care composition, by compounding 3-hydroxybutyric acid and tetrasodium pyrophosphate, so that 3-hydroxybutyric acid and tetrasodium pyrophosphate also exhibit excellent tooth whitening effect at a lower concentration, which can effectively reduce the amount of tetrasodium pyrophosphate, thereby avoiding the problem of tooth health caused by long-term use of high-concentration tetrasodium pyrophosphate leading to tooth decalcification. DETAILED DESCRIPTION

[0016] The present application will be further described below in conjunction with examples, but does not constitute any limitation on the present application, and any limited modifications made within the scope of the claims of the present application are still within the scope of the claims of the present application.

[0017] In order to illustrate the technical content of the present application, the following further illustrates the embodiments.

[0018] In the following examples and comparative examples, the CAS number of the D-3-hydroxybutyric acid is 625-72-9; the CAS number of the tetrasodium pyrophosphate is 7722-88-5; the CAS number of the sodium phytate is 14306-25-3; the CAS number of the pentasodium triphosphate is 7758-29-4; and the CAS number of the sodium hexametaphosphate is 68915-31-1.

[0019] It should be noted that the technical solution of the present application can be realized by commercially available products, and the above CAS numbers are used to confirm the molecular structure for implementation by those skilled in the art.

[0020] In the following examples and comparative examples, the parts are weight parts and the % is weight percentage, unless otherwise specified.

[0021] The compositions were prepared according to the formulation table of Table 1, and the preparation method was: stirring uniformly at 55±5°C, 1000r / min.

[0022] Table 1 Formulation table of oral care compositions D-3-hydroxybutyric acid (parts) Tetrasodium pyrophosphate (parts) Sodium phytate (parts) Pentasodium tri-polyphosphate (parts) Sodium hexametaphosphate (parts) Example 1 1 1 0 0 0 Example 2 0.3 1 0 0 0 Example 3 0.1 1 0 0 0 Example 4 0.05 1 0 0 0 Example 5 0.01 1 0 0 0 Example 6 0.001 1 0 0 0 Comparative Example 1 0 1 0 0 0 Comparative Example 2 1 0 0 0 0 Comparative Example 3 0 0 1 0 0 Comparative Example 4 0 0 0 1 0 Comparative Example 5 0 0 0 0 1 Comparative Example 6 0.05 0 1 0 0 Comparative Example 7 0.05 0 0 1 0 Comparative Example 8 0.05 0 0 0 1

[0023] Whitening efficacy test Test method Evaluation method of removing extrinsic stains on teeth: The compositions of Examples 1-6 and Comparative Examples 1-8 were prepared into 1% aqueous solution respectively. Used for stain removal test.

[0024] According to the experimental method in T / COCIA 26-2024 Efficacy Evaluation of Oral Cleaning and Care Products: In Vitro Efficacy Evaluation of Preventing and Decomposing Extrinsic Stains on Teeth, the HAP tablets were soaked in black tea solution for 3 minutes, taken out, washed with deionized water to remove the residual liquid on the surface, and the surface water was absorbed with a paper towel. The colorimeter was used to test the color Lab value of the HAP tablets, and the value was recorded. After the test, the HAP tablets were soaked in the aqueous solution of the composition to be tested for 2 minutes, taken out, and the Lab value was retested after repeated rinsing and drying. The difference between the color L value of the HAP after staining and decolorization was compared, ΔL value = L value after decolorization - L value after staining. The larger the ΔL value, the stronger the ability to remove extrinsic stains on teeth, and the better the stain removal effect.

[0025] Examples 1-6 and Comparative Examples 1-8 were tested according to the above method, and the results are shown in Table 2.

[0026] Table 2 Whitening efficacy test results of Examples 1-6 and Comparative Examples 1-8 Depigmentation effect ΔL value Example 1 8.03 Example 2 9.56 Example 3 11.53 Example 4 10.93 Example 5 9.13 Example 6 8.39 Comparative Example 1 6.43 Comparative Example 2 0.06 Comparative Example 3 3.85 Comparative Example 4 3.69 Comparative Example 5 4.52 Comparative Example 6 3.62 Comparative Example 7 3.75 Comparative Example 8 4.08

[0027] According to the results in Table 2: According to the data of Comparative Examples 1-5, in the part of tooth whitening effect, 1% concentration, tetrasodium pyrophosphate > sodium hexametaphosphate > sodium pentasodium tripolyphosphate > sodium phytate > D-3-hydroxybutyric acid.

[0028] However, as can be seen from Examples 1-6 of this application, when tetrasodium pyrophosphate and D-3-hydroxybutyric acid are used in combination, the stain removal effect of the composition can be significantly improved. It can be inferred that the combination of tetrasodium pyrophosphate and D-3-hydroxybutyric acid has a synergistic effect on improving the teeth whitening effect of the composition. Generally, the higher the concentration of D-3-hydroxybutyric acid in the composition, the more obvious the synergistic effect and the higher the stain removal effect ΔL value. However, the technical solution of Example 2, with a ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate of 0.3:1, produced an exception. Its stain removal effect was weaker than that of Examples 3 and 4, and even similar to that of Example 5. Therefore, it is reasonable to believe that the technical solution of this application, with a specific ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate, can exert a better synergistic effect.

[0029] Based on the data from Examples 4 and Comparative Examples 6-8, combined with the data from Comparative Examples 1-6, it can be inferred that D-3-hydroxybutyric acid only produces a synergistic effect in enhancing the teeth whitening efficacy of the composition when combined with tetrasodium pyrophosphate. Other components that also have the ability to chelate calcium ions do not produce a synergistic effect with D-3-hydroxybutyric acid.

[0030] Based on the synergistic effect of the combination of D-3-hydroxybutyric acid and tetrasodium pyrophosphate, the applicant infers that its mechanism of whitening and protecting dental health is as follows: 3-Hydroxybutyric acid (3-HHBPA) can precisely remove stains from tooth surfaces by forming pentacyclic chelates with colored metal ions through its hydroxyl and carboxyl groups. This is achieved without affecting the normal mineralization process or the tooth's resistance to decay. Furthermore, 3-HHBPA is weakly acidic and lipophilic, allowing it to penetrate the stain-enamel interface and disrupt the chromogen polymer. Tetrasodium pyrophosphate also has a high affinity for Ca²⁺. + The Fe³⁺ chelating action prevents remineralization of the stain matrix and inhibits tartar formation. The two work synergistically to enhance the whitening and stain removal effect, reduce the concentration of tetrasodium pyrophosphate used, and 3-hydroxybutyric acid has a relatively weak ability to chelate calcium ions. Long-term use will not cause tooth demineralization problems.

[0031] The embodiments presented herein are merely selected implementations based on combinations of all possible embodiments. The appended claims should not be limited to the embodiments described herein. Some numerical ranges used in the claims include sub-ranges within them, and variations within these ranges should also be covered by the appended claims.

Claims

1. An oral care composition, characterized in that, It includes D-3-hydroxybutyric acid and tetrasodium pyrophosphate, wherein the mass ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate is 0.001-1:

1.

2. The oral care composition according to claim 1, characterized in that, The mass ratio of D-3-hydroxybutyric acid to tetrasodium pyrophosphate is 0.05-0.8:

1.

3. Use of oral care products prepared using the oral care composition as described in claim 1 or 2.

4. An oral care product, characterized in that, Contains 0.5-2 wt% of the oral care composition as described in claim 1 or 2.

5. The oral care product according to claim 4, characterized in that, The oral care products include one of toothpaste, mouthwash, and oral spray.