A multi-layer composite medical antibacterial dressing and a preparation method thereof

By designing a multi-layered composite medical dressing, combining a polydopamine-mediated antibacterial coating and carboxymethyl cellulose-gelatin hydrogel, the shortcomings of traditional dressings in terms of antibacterial, anti-inflammatory, and moisturizing properties are solved, achieving effective treatment and healing of wounds.

CN120960483BActive Publication Date: 2026-07-03JIANGSU JINYOU MEDICAL TECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU JINYOU MEDICAL TECHNOLOGY CO LTD
Filing Date
2025-09-04
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing medical dressings are insufficient in terms of antibacterial properties, anti-inflammatory properties, moisturizing properties, and mechanical strength, making it difficult to simultaneously meet the treatment needs of chronic or infected wounds.

Method used

It adopts a multi-layer composite structure, including a waterproof and breathable layer, an antibacterial and adsorbent intermediate layer, and a hydrophilic and healing inner layer. The antibacterial and anti-inflammatory composite coating is formed by grafting heparin sodium and O-chitosan quaternary ammonium salt through polydopamine, and the hydrophilic and healing inner layer is used as a dual-network hydrogel of carboxymethyl cellulose and gelatin.

Benefits of technology

It achieves long-lasting antibacterial and anti-inflammatory functions, improves wound healing, reduces the risk of infection, maintains the stability of the wound microenvironment, and promotes tissue repair.

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Abstract

This invention discloses a multi-layered composite medical antibacterial dressing and its preparation method, relating to the field of medical dressing technology. It comprises a waterproof and breathable layer, an antibacterial adsorption intermediate layer, and a hydrophilic healing-promoting inner layer, from the outside in. The waterproof and breathable layer is a polyurethane breathable membrane with a polydopamine-nano silver composite coating. The antibacterial adsorption intermediate layer consists of an activated carbon fiber nonwoven fabric substrate and an antibacterial and anti-inflammatory composite coating grafted onto the substrate surface. The hydrophilic healing-promoting inner layer is a carboxymethyl cellulose and gelatin dual-network hydrogel loaded with compound comfrey oil. This invention achieves long-lasting antibacterial and anti-inflammatory functions through activated carbon fiber nonwoven fabric grafted with heparin sodium and O-chitosan quaternary ammonium salt via polydopamine-mediated delivery. This solves the problems of easy detachment of antibacterial agents and weak anti-inflammatory effects in traditional antibacterial dressings, leading to repeated wound infections or prolonged inflammation, thus reducing wound infection rates and alleviating inflammatory responses.
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Citation Information

Patent Citations

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