环戊烯并[b]吲哚-1-酮类化合物及其制备方法和在制备抗神经胶质瘤药物中的应用
Cyclopenteno[b]indole-1-one compounds were prepared by a tandem cyclization reaction under alkaline conditions, which solved the safety and operational complexity problems of the prior art, and realized safe and efficient compound preparation and industrial application, with anti-glioma activity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- THE AFFILIATED HOSPITAL OF YUNNAN UNIVERSITY
- Filing Date
- 2025-09-10
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for synthesizing cyclopentenoid[b]indole compounds suffer from poor production safety and difficulties in industrial application, especially due to the complexity of transition metal catalysis and hydrogen reduction operations.
Cyclopenteno[b]indole-1-one compounds were prepared by tandem cyclization reactions of compounds of formula (I) and formula (II) under alkaline conditions, avoiding transition metal catalysis and hydrogen gas. Hexamethyldisilamide alkali metal salts and aprotic solvents were used, and the reaction conditions were mild, making them suitable for industrial applications.
A safe, simple and efficient method for preparing cyclopentenon[b]indole-1-one compounds is provided, which is suitable for industrial production, and the obtained compounds have significant inhibitory activity against the proliferation of glioma U87MG cells.
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