一种卵丘细胞剥除质量评估方法及装置

By acquiring images of cumulus cells at different focusing levels using deep learning technology, and using feature extraction and fusion structures for cumulus cell identification and pairing, the subjective error and instability problems of cumulus cell removal quality assessment in existing technologies are solved, and accurate quantification and automatic assessment of cumulus cell removal quality are achieved.

CN120976153BActive Publication Date: 2026-07-17SUZHOU BOUNDLESS MEDICAL TECH CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUZHOU BOUNDLESS MEDICAL TECH CO LTD
Filing Date
2025-08-06
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing methods for assessing the quality of cumulus cell removal rely on manual observation or image thresholding, which suffer from large subjective errors or unstable segmentation and recognition, and cannot accurately quantify the quality of cumulus cell removal.

Method used

Deep learning technology is used to acquire cumulus cell images at different focusing levels through YOLO and Siamese or SwAV models. Res2Net-COT residual structure and bidirectional feature pyramid structure are used for feature extraction and fusion. Cell identification and pairing are performed by combining spatial pyramid pooling layer and feature band structure to achieve quantitative evaluation of cumulus cell removal quality.

Benefits of technology

It enables objective and accurate assessment of the quality of cumulus cell removal, reduces the impact of changes in microscope field of view depth and image quality, improves the automation and accuracy of assessment, enhances the ability to identify cumulus cell features, and reduces noise interference.

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Abstract

本发明涉及生物医疗技术领域,公开了一种卵丘细胞剥除质量评估方法及装置,包括在不同聚焦层面,采集卵丘细胞剥除后的待评估卵子的两张聚焦图像,并识别出所有卵丘细胞的位置以及卵丘细胞总数量;对两张聚焦图像中的卵丘细胞总数量求和,获取初始数量;截取两张聚焦图像中的每个卵丘细胞,并令第一聚焦图像中的每个卵丘细胞与第二聚焦图像中的每个卵丘细胞进行两两配对,获取多个卵丘细胞对;识别两个卵丘细胞为同一卵丘细胞的卵丘细胞对的对数,并基于每个卵丘细胞的位置,剔除位置相差大于预设距离的卵丘细胞对,获取可能细胞对数;计算初始数量与可能细胞对数的差,得到待评估卵子周围的卵丘细胞数量,获取待评估卵子的卵丘细胞剥除质量。
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