基于经颅超声刺激的无创神经调控系统

The non-invasive neuromodulation system based on transcranial ultrasound stimulation solves the problem of insufficient spatial resolution and depth in deep brain region stimulation, achieving precise modulation of the hippocampus and amygdala. Combined with online mode for sleep neuromodulation, it is suitable for a wide range of applications.

CN120983832BActive Publication Date: 2026-07-17BEIJING NORMAL UNIVERSITY

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BEIJING NORMAL UNIVERSITY
Filing Date
2025-07-02
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing non-invasive neuromodulation techniques have limited spatial resolution and depth when stimulating deep brain regions, and lack causal exploration of cognitive and behavioral changes, especially the research gaps in precise hippocampal stimulation and the role of the amygdala in anxiety decision-making.

Method used

A non-invasive neuromodulation system based on transcranial ultrasound stimulation is used. The focal length of the ultrasound transducer is calibrated through acoustic simulation. Combined with data acquisition and skin reconstruction, the target trajectory is determined. The Brainsight navigation system and Babelbrain software are used to calculate the focal position. A gel pad of a specific shape is used to ensure effective propagation of ultrasound waves and achieve precise stimulation.

Benefits of technology

It achieves high-precision stimulation of deep brain regions such as the hippocampus and amygdala, improves spatial resolution and stimulation depth, can analyze changes in nervous system activity, is suitable for general subjects, and can perform sleep neuromodulation in online mode.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明公开了一种基于经颅超声刺激的无创神经调控方法及系统。该方法包括如下步骤:通过声学模拟对超声换能器的焦距进行校准;获取用户的T1加权结构像数据,并转化为伪CT图像;基于用户的T1加权结构像数据,配合标准模板中的海马头掩膜,重建用户的头部皮肤;基于用户的头部皮肤,确定超声换能器与用户的头部皮肤最贴合的位置,从而建立靶点的轨迹;基于靶点的轨迹,通过模拟超声路径,以基于靶点的轨迹对超声换能器的焦点位置进行矫正,以形成焦点的轨迹;基于焦点的轨迹,控制超声换能器按照预设参数运行,以用于实施经颅超声刺激。由此,采用经颅超声刺激的方式能够精准刺激深部脑区,而且无需开颅,更适合在普通被试群体大范围开展。
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