An experimental animal aseptic isolation feeding cabin

Abstract

The application provides an experimental animal aseptic isolation feeding cabin, and relates to the technical field of aseptic animal feeding.The aseptic isolation feeding cabin comprises a cabin body shell, an aseptic air exchange top cover structure and an intermediate transfer channel.A partition is arranged in the cabin body shell, which divides the cabin body shell into a feeding bin, an inner transfer channel and a bottom bin.A transfer mechanism is arranged in the inner transfer channel, which comprises a closed cover body assembly and a bearing transfer assembly, and can move vertically in the channel to ensure that the aseptic environment of the feeding bin is not damaged when the experimental animals are transferred.The intermediate transfer channel is connected to the transfer exit of the side wall of the cabin body shell, and the safe transfer of the experimental animals under aseptic conditions is realized.The closed transfer design avoids the contact of the experimental animals with the external environment, ensures the aseptic state and improves the transfer efficiency.The aseptic feeding and cross-cabin transfer of the experimental animals meet the high-standard biological experiment requirements.

Description

Technical Field

[0001] This invention relates to the field of sterile animal husbandry technology, and in particular to a sterile isolation husbandry chamber for laboratory animals. Background Technology

[0002] Laboratory animals play a vital role in biomedical research, and their housing environment must be strictly sterile to avoid interfering with experimental results. Sterile isolation chambers are widely used in laboratory animal husbandry. These chambers maintain a sterile internal environment through highly efficient filtration and ventilation systems. Aseptic isolation chambers for laboratory animals are key equipment in biomedical research for raising animals with sterile or known microbial communities. Their core objective is to eliminate microbial interference and ensure the reliability of experimental results.

[0003] During experiments, animals often need to be transferred to other experimental chambers or testing equipment. Traditional transfer methods (such as direct removal or open transfer) can easily disrupt the sterile environment and increase the risk of contamination. In existing technologies, some isolation chambers use simple transfer window structures, but there is still a risk of brief exposure during operation, and continuous and efficient animal transfer cannot be achieved. Summary of the Invention

[0004] The purpose of this invention is to provide a sterile isolation and rearing chamber for laboratory animals to solve the technical problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: A sterile isolation and rearing chamber for laboratory animals includes an outer shell, a sterile ventilation top cover structure, and an intermediate transfer channel. The sterile ventilation top cover structure is located on the top of the outer shell and is used to regulate the sterile environment inside the outer shell. The outer shell has a partition that divides the interior into a rearing compartment, an inner transfer channel, and a bottom compartment. The inner transfer channel is located inside the outer shell near the side wall and communicates with the rearing compartment. A transfer inlet / outlet, communicating with the inner transfer channel, is located at the bottom of the outer wall of the outer shell. The inner transfer channel contains a transfer mechanism capable of vertical movement within the inner transfer channel. The device is movable and includes a closed cover assembly and a carrying and transporting assembly. The closed cover assembly is located inside the inner transfer channel and moves vertically within it. The carrying and transporting assembly is located on the closed cover assembly and is used to support the experimental animals to be transferred. When the carrying and transporting assembly is in a position corresponding to the transfer entrance / exit, the top of the closed cover assembly closes the connection between the inner transfer channel and the rearing chamber. The intermediate transfer channel is located on the side wall of the outer shell of the chamber and corresponds to the transfer entrance / exit. The carrying and transporting assembly can move inside the intermediate transfer channel. Two long-sleeved gloves are also provided on the side wall of the outer shell of the chamber, with one end of the long-sleeved gloves extending into the rearing chamber.

[0006] Based on the above technical solutions, the present invention also provides the following optional technical solutions: In one alternative embodiment: the aseptic ventilation top cover structure includes a top cover, a disinfectant sprayer, and an integrated ventilation unit. The top cover is detachably mounted on the top of the outer shell of the chamber. The disinfectant sprayer and the integrated ventilation unit are both mounted on the top cover. One end of the disinfectant sprayer is connected to an external liquid supply system, and the other end extends into the rearing bin. The disinfectant sprayer is used to spray disinfectant from the liquid supply system into the rearing bin. The integrated ventilation unit is equipped with a filter, a thermostat, a sterilizer, and a humidity regulator.

[0007] In one alternative embodiment: the intermediate transfer channel includes a channel body, a front sealing plate, and a rear sealing plate. The channel body is fixed to the outer wall of the cabin shell and aligned with the transfer inlet / outlet. The front sealing plate is located at the end of the channel body facing the transfer inlet / outlet and can slide laterally. The rear sealing plate is located at the end of the channel body away from the transfer inlet / outlet and can slide laterally. Both the rear sealing plate and the front sealing plate are connected to the outer wall of the channel body via opening and closing cylinders. The end of the channel body away from the cabin shell also has a connecting flange for connecting to an external cabin.

[0008] In one alternative embodiment: the enclosed cover assembly includes an upper cover, a transfer support plate, and at least one transfer cylinder. The upper cover and the transfer support plate are arranged opposite to each other, and both edges are capable of sliding and sealing with the inner wall of the inner transfer channel. The upper cover and the transfer support plate are connected by at least one hanging rod. The load-bearing transfer assembly is disposed on the transfer support plate and can move from one end of the transfer support plate toward the transfer inlet / outlet into the intermediate transfer channel. The transfer cylinder is disposed on the upper end face of the upper cover, and one end of the transfer cylinder is connected to the top of the feeding bin.

[0009] In one alternative: the upper surface of the transfer support plate is provided with two plate slides pointing to the middle transfer channel. The load-bearing transfer assembly includes a transfer plate, lower sliding supports, and a forward drive unit. There are two lower sliding supports, which are correspondingly located at the bottom of the transfer plate. The lower sliding supports can slide and lock onto the corresponding plate slides. The forward drive unit is located at the bottom of the transfer plate and is used to drive the lower sliding supports to move forward along the plate slides. The main body of the channel is also provided with two channel slides that are respectively connected to the two plate slides.

[0010] In one alternative: the transfer support plate is provided with a carrier plate rack parallel to the carrier plate slide, and the channel body is provided with a channel rack that can engage with the carrier plate rack along its length; the forward drive unit includes a forward motor and two forward rotating shafts, which are arranged in parallel between two lower sliding supports. The ends of the forward rotating shafts are rotatably connected to the side walls of the lower sliding supports. The output end of the forward motor is connected to the end of one of the forward rotating shafts. The two forward rotating shafts are also connected by a belt drive. Each forward rotating shaft is provided with a forward gear that can mesh with the carrier plate rack and the channel rack.

[0011] In one alternative embodiment: the two lower sliding supports have protruding ribs on their opposite sidewalls; the transfer support plate is provided with two abutting units located on the sides of the two lower sliding supports respectively; each abutting unit includes an upper top and a movable part; the upper top is slidably inserted through the transfer support plate, and its bottom is bent and connected to the bottom of the transfer support plate via a downward spring; the movable part is slidably disposed on the upper surface of the transfer support plate, with a holding part at the end of the movable part facing the lower sliding support, and the end of the movable part away from the lower sliding support connected to the side of the transfer support plate via a release spring; the top of the upper top contacts the inclined surface of the lower surface of the movable part; and the bottom of the outer shell of the cabin has a base plate; when the load-bearing transfer assembly is located at a position corresponding to the transfer inlet / outlet, the bottom of the upper top abuts against the base plate and moves upward.

[0012] By adopting the above technical solution, the present invention has the following beneficial effects: The sterile isolation rearing chamber for laboratory animals provided by this invention dynamically seals the connection between the inner transfer channel and the rearing chamber during the transfer process through a closed cover assembly, ensuring that the rearing chamber remains sterile and preventing external contamination. The two ends of the intermediate transfer channel can be opened and closed independently, coordinating with the movement of the transport components to enable the transfer of laboratory animals across chambers in a completely enclosed environment, eliminating exposure risks. The long-sleeved glove design allows staff to operate under sterile conditions, and the automated movement of the transfer mechanism reduces human intervention and improves transfer efficiency. The inner transfer channel is located along the side wall of the chamber, saving space, while the flexible connection between the transfer entrance / exit and the intermediate transfer channel adapts to different external chamber requirements. The fully enclosed transfer mechanism is suitable for high-cleanliness experimental scenarios, ensuring the sterility of the laboratory animals and the accuracy of experimental data. Attached Figure Description

[0013] To more clearly illustrate the specific embodiments of the present invention or the technical solutions in the prior art, the drawings used in the description of the specific embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0014] Figure 1 This is a schematic diagram of the aseptic isolation breeding chamber from one perspective in one embodiment of the present invention.

[0015] Figure 2 This is a schematic diagram of the aseptic isolation breeding chamber from another perspective in one embodiment of the present invention.

[0016] Figure 3 This is a schematic diagram of a sterile isolation breeding chamber structure with the sterile ventilation top cover structure removed, according to one embodiment of the present invention.

[0017] Figure 4 This is a schematic diagram of the internal structure of the cabin shell in one embodiment of the present invention.

[0018] Figure 5 This is a schematic diagram of the structure of the carrier-transfer component on the closed cover component in one embodiment of the present invention.

[0019] Figure 6 This is a schematic diagram of the forward drive unit structure in one embodiment of the present invention.

[0020] Figure 7 This is a schematic diagram of the intermediate transfer channel structure in one embodiment of the present invention.

[0021] Figure 8 This is a schematic diagram of the internal structure of the intermediate transfer channel in one embodiment of the present invention.

[0022] Figure 9 This is a schematic diagram of the clamping unit structure in one embodiment of the present invention.

[0023] Reference numerals in the attached drawings: hull shell 100, base plate 110, transparent observation window 120, control panel 130, long-sleeved glove 140, transfer entrance / exit 150, top cover 200, intermediate transfer channel 300, channel body 310, front sealing plate 320, rear sealing plate 330, opening / closing cylinder 340, connecting flange 350, channel slide 360, channel rack 370, partition 400, internal transfer channel 410, transfer mechanism 500, load-bearing transfer assembly 510, transfer carrier plate 511, lower sliding support 51 2. 5121 protruding part, 513 forward drive unit, 5131 forward motor, 5132 forward rotating shaft, 5133 belt drive part, 5134 forward gear part, 520 upper cover, 530 transfer cylinder, 540 inner chamber sensor, 550 lifting rod part, 560 transfer support plate, 561 carrier slide, 562 carrier rack, 570 pressing unit, 571 upper top, 572 moving part, 573 holding part, 574 downward spring, 575 releasing spring, 600 disinfection sprayer, 700 integrated ventilation unit. Detailed Implementation

[0024] The technical solution of the present invention will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0025] The left, right, up, and down positions of the various components shown in the attached diagram are just one arrangement method; the specific positions should be set according to specific needs.

[0026] In one embodiment, such as Figures 1-5 As shown, a sterile isolation rearing chamber for laboratory animals includes an outer shell 100, a sterile ventilation top cover structure, and an intermediate transfer channel 300. The sterile ventilation top cover structure is located on top of the outer shell 100 and is used to regulate the sterile environment inside the outer shell 100. A partition 400 is provided inside the outer shell 100, dividing the interior into a rearing compartment, an inner transfer channel 410, and a bottom compartment. The inner transfer channel 410 is located inside the outer shell 100 near the side wall and communicates with the rearing compartment. A transfer inlet / outlet 150 communicating with the interior of the inner transfer channel 410 is provided at the bottom of the outer wall of the outer shell 100. A transfer mechanism 500 is provided inside the inner transfer channel 410, which is capable of transferring animals within the inner transfer channel. The inner transfer channel 410 is vertically movable and includes a closed cover assembly and a carrying and transporting assembly 510. The closed cover assembly is located inside the inner transfer channel 410 and moves vertically within it. The carrying and transporting assembly 510 is located on the closed cover assembly and is used to support the experimental animals to be transferred. When the carrying and transporting assembly 510 is in a position corresponding to the transfer entrance / exit 150, the top of the closed cover assembly closes the connection between the inner transfer channel 410 and the rearing bin. The intermediate transfer channel 300 is located on the side wall of the outer shell 100 and corresponds to the transfer entrance / exit 150. The carrying and transporting assembly 510 can move inside the intermediate transfer channel 300. Two long-sleeved gloves 140 are also provided on the side wall of the outer shell 100, with one end of the long-sleeved gloves 140 extending into the rearing bin.

[0027] In this embodiment of the invention, experimental animals are kept in a rearing chamber. When it is necessary to transfer the experimental animals from the rearing chamber to another external chamber, the external chamber is installed at the end of the intermediate transfer channel 300 away from the outer shell 100. Both ends of the intermediate transfer channel 300 are sealed. The operator's hands are inserted into long-sleeved gloves 140, which isolate the operator's hands and do not affect the environment inside the rearing chamber. The operator, with their hands through the long-sleeved gloves 140, places the experimental animals to be transferred onto the carrying and transporting component 510 of the transfer mechanism 500. At this time, the bottom of the closed cover assembly seals the connection between the incubation chamber and the inner transfer channel 410. The closed cover assembly operates and moves inside the inner transfer channel 410. The transport assembly 510 and the experimental animals on it follow the closed cover assembly downwards until the transport assembly 510 moves to the transfer inlet / outlet 150. The top of the closed cover assembly seals the connection between the inner transfer channel 410 and the incubation chamber, maintaining the closed state of the incubation chamber and a sterile environment. At this time, the end of the intermediate transfer channel 300 near the transfer inlet / outlet 150 opens, and the transport assembly 510 passes through the transfer inlet / outlet 150. The transport assembly 510 moves into the intermediate transfer channel 300. Once the transport assembly 510 and the experimental animal on it are fully inside the intermediate transfer channel 300, the end of the intermediate transfer channel 300 near the transfer entrance / exit 150 is closed, and the end of the intermediate transfer channel 300 near the outer chamber is opened. The transport assembly 510 moves along the intermediate transfer channel 300 towards the outer chamber. After the transport assembly 510 reaches the outer chamber, the staff quickly transfers the experimental animal on the transport assembly 510 into the outer chamber. The transport assembly 510 then moves back along the intermediate transfer channel 300. The animal is then moved to the rearing chamber via the inner transfer channel 410 onto the sealed cover assembly for the next animal transfer. During animal transfer, the transfer mechanism 500 uses the sealed cover assembly to close the connection between the inner transfer channel 410 and the rearing chamber, ensuring the rearing chamber remains closed and the environment is regulated by the sterile ventilation top cover structure, effectively maintaining a sterile environment. The opening and closing of both ends of the intermediate transfer channel 300 isolates the transferring animal from the outside environment, preventing contact and ensuring the animal is transferred in a sterile environment.

[0028] In one embodiment, such as Figures 1-5As shown, the aseptic ventilation top cover structure includes a top cover 200, a disinfectant sprayer 600, and an integrated ventilation unit 700. The top cover 200 is detachably mounted on the top of the outer shell 100 of the housing. The disinfectant sprayer 600 and the integrated ventilation unit 700 are both mounted on the top cover 200. One end of the disinfectant sprayer 600 is connected to an external liquid supply system, and the other end extends into the rearing bin. The disinfectant sprayer 600 is used to spray disinfectant from the liquid supply system into the rearing bin. The ventilation unit 700... The integrated unit 700 is internally equipped with a filter, thermostat, sterilizer, and humidity regulator. In this embodiment of the invention, the integrated ventilation unit 700 is used to introduce outdoor airflow into the rearing chamber after it has been filtered, the temperature has been regulated by the thermostat, the microorganisms have been killed by the sterilizer, and the humidity has been humidified by the humidity regulator, so as to regulate the sterile environment in the rearing chamber. At the same time, the integrated ventilation unit 700 also exhausts the airflow inside the integrated ventilation unit 700 to achieve ventilation. The sterilizer can be an ultraviolet lamp or a plasma sterilizer.

[0029] In one embodiment, such as Figures 1-8 As shown, the intermediate transfer channel 300 includes a channel body 310, a front sealing plate 320, and a rear sealing plate 330. The channel body 310 is fixed to the outer wall of the outer shell 100 and aligned with the transfer inlet / outlet 150. The front sealing plate 320 is located at the end of the channel body 310 facing the transfer inlet / outlet 150 and can slide laterally. The rear sealing plate 330 is located at the end of the channel body 310 away from the transfer inlet / outlet 150 and can slide laterally. Both the rear sealing plate 330 and the front sealing plate 320 are connected to the outer wall of the channel body 310 via opening / closing cylinders 340. Furthermore, the end of the channel body 310 away from the outer shell 100 also has a connecting flange 350 for connecting with the external cabin. In this embodiment of the invention, the opening and closing cylinder 340 drives the rear sealing plate 330 or the front sealing plate 320 to move laterally at the end of the channel body 310 through telescopic drive, so as to realize the closure and opening of the end of the channel body 310, realize isolation from the external environment during the transfer process, and ensure sterile transfer. The connection between the connecting flange 350 and the external cabin is a detachable connection, and various types of cabins can be installed as needed, such as experimental cabins, physical examination cabins, or breeding and pairing cabins.

[0030] In one embodiment, such as Figure 1-3As shown, the closed cover assembly includes an upper cover 520, a transfer support plate 560, and at least one transfer cylinder 530. The upper cover 520 and the transfer support plate 560 are arranged opposite each other, and both edges can slide and seal against the inner wall of the inner transfer channel 410. The upper cover 520 and the transfer support plate 560 are connected by at least one hanging rod 550. The carrying transfer assembly 510 is disposed on the transfer support plate 560 and can move from one end of the transfer support plate 560 toward the transfer inlet / outlet 150 into the intermediate transfer channel 300. The transfer cylinder 530 is disposed on the upper surface of the upper cover 520, and one end of the transfer cylinder 530 is connected to the top of the feeding bin. In this embodiment of the invention, the transfer cylinder 530 is connected to the upper surface of the upper cover 520. The upper cover 520 moves vertically through its own telescopic movement, and the transfer support plate 560 moves with the upper cover 520 to drive the transport component 510 to move vertically. The transport component 510 can move to the connection between the inner transfer channel 410 and the breeding chamber or to the transfer entrance / exit 150 to realize the transfer of experimental animals. The edges of the transfer support plate 560 and the edges of the upper cover 520 are slidably engaged with the inner wall of the inner transfer channel 410 to achieve the sealing of the breeding chamber when transferring experimental animals. The upper cover 520 is also equipped with multiple inner chamber sensors 540, which correspond to various sensors such as temperature sensors, humidity sensors, and biosensors to sense the sterile environment inside the breeding chamber.

[0031] In one embodiment, such as Figures 1-8 As shown, the upper surface of the transfer support plate 560 is provided with two plate slides 561 pointing towards the central transfer channel 300. The transport assembly 510 includes a transfer plate 511, lower sliding supports 512, and a forward drive unit 513. Two lower sliding supports 512 are correspondingly located at the bottom of the transfer plate 511, and each lower sliding support 512 can slidably engage with the corresponding plate slide 561. The forward drive unit 513 is located at the bottom of the transfer plate 511 and is used to drive the lower sliding supports 512 to move forward along the plate slide 561. The channel body 310 also has two additional tracks connecting to the two plate slides 561. The corresponding channel slide 360; In this embodiment of the invention, the transfer plate 511 is used to carry experimental animals. Due to the slidable engagement between the lower sliding support 512 and the plate slide 561, the transfer plate 511 moves vertically along the transfer support plate 560. When the transfer support plate 560 moves to the transfer inlet / outlet 150 and is aligned with the end of the channel slide 360 ​​in the intermediate transfer channel 300, the forward drive unit 513 works. The forward drive unit 513 drives the transfer plate 511 and the forward drive unit 513 to move along the plate slide 561 and the channel slide 360 ​​to realize the transportation of experimental animals inside the intermediate transfer channel 300.

[0032] In one embodiment, such as Figures 1-8As shown, the transfer support plate 560 is provided with a carrier plate rack 562 parallel to the carrier plate slide 561, and the channel body 310 is provided with a channel rack 370 along its length direction that can engage with the carrier plate rack 562; the forward drive unit 513 includes a forward motor 5131 and two forward rotating shafts 5132, which are arranged in parallel between two lower sliding supports 512. The ends of the forward rotating shafts 5132 are rotatably connected to the side walls of the lower sliding supports 512. The output end of the forward motor 5131 is connected to the end of one of the forward rotating shafts 5132. The two forward rotating shafts 5132 are also connected by a belt drive part 5133. Each forward rotating shaft 5132 is provided with a forward gear part 5134 that can mesh with the carrier plate rack 562 and the channel rack 370; In this embodiment of the invention, when it is necessary to transfer the actual When experimental animals are transported to the outer chamber or when experimental animals in the outer chamber are transported into the inner transfer channel 410, the forward moving shaft 5132 works and drives the forward moving shaft 5132 to rotate. Since the two forward moving shafts 5132 are connected by a belt drive 5133, the two forward moving shafts 5132 rotate synchronously. Therefore, the two forward moving gears 5134 rotate synchronously and move along the carrier rack 562 and the channel rack 370 by meshing with the carrier rack 562 and the channel rack 370. Since the two forward moving gears 5134 rotate synchronously, the forward movement of the entire carrying and transfer assembly 510 will not be affected by the disconnection at the end of the carrier rack 562 and the end of the channel rack 370. Therefore, the lower sliding support 512 and the transfer carrier 511 move with the forward moving shaft 5132, thereby realizing the transport of experimental animals.

[0033] In one embodiment, such as Figures 1-9As shown, the two lower sliding supports 512 have protruding strips 5121 on their opposite sidewalls. The transfer support plate 560 is provided with two abutting units 570 located on the sides of the two lower sliding supports 512 respectively. Each abutting unit 570 includes an upper top 571 and a movable part 572. The upper top 571 slidably penetrates the transfer support plate 560, and its bottom is bent and connected to the bottom of the transfer support plate 560 via a downward spring 574. The movable part 572 is slidably disposed on the upper surface of the transfer support plate 560, facing the lower sliding supports 512. The end of the upper top 571 has a supporting portion 573, and the end of the movable portion 572 away from the lower sliding support 512 is connected to the side of the transfer support plate 560 through a release spring 575. The top of the upper top 571 contacts the inclined surface of the lower surface of the movable portion 572, and the bottom of the outer shell 100 has a bottom plate 110. When the carrying and transferring assembly 510 is located in a position corresponding to the transfer inlet / outlet 150, the bottom of the upper top 571 abuts against the bottom plate 110 and moves upward. In this embodiment of the invention, when the carrying and transferring assembly 510 is not in a position corresponding to the transfer inlet / outlet 150, the bottom of the upper top 571... The upper part 571 no longer abuts against the upper surface of the base plate 110. Under the elastic force of the downward spring 574, the upper top 571 moves downward. The top of the upper top 571 no longer acts on the movable part 572. Under the elastic force of the released spring 575, the movable part 572 moves downward to the sliding support 512. The abutting part 573 abuts against the side wall of the lower sliding support 512, and the friction between the abutting part 573 and the protruding part 5121 restricts the movement of the movable part 572 on the carrier slide 561, thereby ensuring the stability of the load-bearing transfer assembly 510 when it moves vertically inside the inner transfer channel 410; when the load-bearing transfer assembly 510 moves vertically, the upper top 571 moves downward. When the transport component 510 is positioned corresponding to the transfer inlet / outlet 150, the bottom of the upper top 571 abuts against the bottom base plate 110 and moves upward. Since the top of the upper top 571 contacts the bottom slope of the movable part 572, the upward-moving upper top 571 pushes the movable part 572 laterally, so that the abutting part 573 moves away from the lower sliding support 512. Thus, the abutting part 573 no longer restricts the movement of the lower sliding support 512, making it easier for the lower sliding support 512 to move in the carrier slide 561, so as to realize the transfer of experimental animals from the interior of the intermediate transfer channel 300 to the external cabin.

[0034] In one embodiment, such as Figure 1-3As shown, a transparent observation window 120 and a control panel 130 are also provided on the outer wall of the outer shell 100 of the chamber. The disinfectant sprayer 600, the integrated ventilation unit 700 and multiple internal chamber sensors 540 are all electrically connected to the control panel 130. In this embodiment of the invention, the growth of experimental animals in the breeding chamber can be observed through the transparent observation window 120. The internal chamber sensors 540 sense the temperature, humidity and animal growth in the breeding chamber and generate signals. The control panel 130 receives the sensed signals and controls the disinfectant sprayer 600 and the integrated ventilation unit 700 to work in order to adjust the environment in the breeding chamber.

[0035] The above embodiments provide a sterile isolation and rearing chamber for laboratory animals, the working principle of which is as follows: 1. Maintenance and regulation of a sterile environment Ventilation and Sterilization: The integrated ventilation unit 700 in the aseptic ventilation top cover structure filters, sterilizes, temperature-regulates and humidifies external air through built-in filters, sterilizers such as ultraviolet lamps or plasma sterilizers, thermostats and humidity regulators, and introduces it into the breeding bins, while simultaneously expelling waste gas from the bins to maintain a constant aseptic environment.

[0036] Disinfection assistance: The 600 disinfection sprayer can spray disinfectant into the breeding bins to further kill residual microorganisms and ensure a sterile environment.

[0037] 2. Internal transfer in laboratory animals Initial state: The experimental animals are located in the breeding chamber. The carrying and transporting component 510 of the transfer mechanism 500 is located above the inner transfer channel 410. The upper cover 520 of the sealing cover component and the transport support plate 560 respectively seal the upper and lower ends of the inner transfer channel 410 to prevent cross-contamination between the inside and outside of the chamber.

[0038] Animal loading: Workers place the animals onto the transfer carrier 511 using long-sleeved gloves 140. At this time, the bottom of the sealing cover assembly seals the connection between the rearing compartment and the inner transfer channel 410, ensuring the rearing compartment is sealed.

[0039] 3. Vertical transport and channel switching The downward movement process: The transfer cylinder 530 drives the upper cover 520 and the transfer support plate 560 to move downward, causing the carrier transfer assembly 510 to descend to the transfer inlet / outlet position 150. At this time, the upper cover 520 closes the top of the inner transfer channel 410, maintaining a sterile environment in the breeding chamber.

[0040] Release of clamping unit: When the transfer support plate 560 reaches the bottom, the upper top 571 of the clamping unit 570 contacts the bottom plate 110 and pushes upward, pushing the movable part 572 to release the lock on the lower sliding support 512, allowing the transport assembly 510 to move laterally.

[0041] 4. Laterally transported to the external compartment Channel docking and sealing: The front sealing plate 320 of the intermediate transfer channel 300 opens, and the carrier transfer assembly 510, through the gear and rack of the forward drive unit 513, engages with the carrier plate rack 562 and the channel rack 370, and enters the channel body 310 along the carrier plate slide 561 and the channel slide 360. The front sealing plate 320 then closes to ensure that both ends of the channel are sealed.

[0042] External cabin docking: The rear sealing plate 330 is opened, and the transfer carrier plate 511 continues to move to the external cabin, such as the experimental cabin. After the staff quickly transfers the animals, the transport component 510 returns to the breeding cabin along the original path.

[0043] 5. Dynamic environmental monitoring Sensor feedback: The internal sensor 540 monitors the temperature, humidity and biological indicators of the breeding bin in real time, and feeds the data back to the control panel 130, which automatically adjusts the working parameters of the ventilation unit 700 and the disinfection sprayer 600 to ensure a stable environment.

[0044] Key Design Advantages Double sealing mechanism: The alternating opening and closing of the closed cover assembly and the intermediate transfer channel 300 ensures that the breeding chamber is always isolated from the outside world during the transfer process.

[0045] Automated transfer: The coordinated design of gear and rack drive and clamping unit enables precise movement and locking of the load-bearing components, avoiding contamination from manual intervention.

[0046] Modular expansion: The intermediate transfer channel can be adapted to various external chambers via the opening and closing cylinder connecting flange 350, meeting the aseptic transfer requirements of laboratory animals between different functional chambers.

[0047] In the description of this invention, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing the invention and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the invention. Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

Claims

1. A sterile isolation and rearing chamber for laboratory animals, comprising an outer shell, a sterile ventilation top cover structure, and an intermediate transfer channel, wherein the sterile ventilation top cover structure is located on the top of the outer shell and is used to regulate the sterile environment inside the outer shell, characterized in that, The outer shell of the cabin is provided with a partition section, which divides the interior of the cabin shell into a breeding bin, an internal transfer channel and a bottom bin; The internal transfer channel is located inside the outer shell of the cabin, near the side wall, and is connected to the breeding bin. A transfer entrance / exit is provided at the bottom of the outer wall of the cabin, which is connected to the interior of the internal transfer channel. The inner transfer channel is equipped with a transfer mechanism that can move vertically within the inner transfer channel and includes a closed cover assembly and a load-bearing transfer assembly. The closed cover assembly is located inside the inner transfer channel and moves vertically within it. The transport and transfer assembly is located on the closed cover assembly and is used to support the experimental animals that need to be transferred. When the transport component is in the position corresponding to the transfer inlet and outlet, the top of the closed cover component closes the connection between the internal transfer channel and the breeding bin; The intermediate transfer channel is located on the side wall of the outer shell of the cabin and corresponds to the transfer inlet and outlet, allowing the transport components to move inside the intermediate transfer channel. Two long-sleeved gloves are also installed on the side wall of the outer shell of the cabin, with one end of the long-sleeved gloves extending into the inside of the breeding bin. The intermediate transfer channel includes a channel body, a front sealing plate, and a rear sealing plate; The main body of the channel is fixed to the outer wall of the cabin shell and aligned with the transfer entrance / exit. The front sealing plate is located at the end of the main body of the channel facing the transfer entrance / exit and can slide laterally. The rear sealing plate is located at the end of the channel body away from the transfer entrance and exit and can slide laterally. The rear sealing plate and the front sealing plate are connected to the outer wall of the channel body through opening and closing cylinders. The end of the channel body away from the outer shell of the cabin also has a connecting flange for connecting to the external cabin. The closed cover assembly includes an upper cover, a transfer support plate, and at least one transfer cylinder; The upper cover and the transfer support plate are arranged opposite to each other and both edges can slide and seal with the inner wall of the inner transfer channel. The upper cover and the transfer support plate are connected by at least one hanging rod. The carrying and transfer assembly is located on the transfer support plate and can move from one end of the transfer support plate toward the transfer inlet / outlet into the middle transfer channel; the transfer cylinder is located on the upper end face of the upper cover and one end of the transfer cylinder is connected to the top of the breeding bin.

2. The sterile isolation and rearing chamber for laboratory animals according to claim 1, characterized in that, The aseptic ventilation top cover structure includes a top cover, a disinfectant sprayer, and an integrated ventilation unit. The top cover is detachably located on the top of the outer shell of the chamber. The disinfection sprayer and the integrated ventilation unit are both located on the top cover. One end of the disinfection sprayer is connected to the external liquid supply system and the other end extends into the inside of the breeding bin. The disinfection sprayer is used to spray the disinfectant in the liquid supply system into the breeding bin. The integrated ventilation unit is equipped with a filter, thermostat, sterilizer and humidity regulator.

3. The sterile isolation and rearing chamber for laboratory animals according to claim 1, characterized in that, The upper surface of the transfer support plate is provided with two plate slides pointing to the middle transfer channel. The load-bearing transfer assembly includes a transfer plate, a lower sliding support, and a forward drive unit. The lower sliding supports are two in number and are correspondingly located at the bottom of the transfer plate. The lower sliding supports can slide and lock onto the corresponding plate slides. The forward drive unit is located at the bottom of the transfer plate and is used to drive the lower sliding supports to move forward along the plate slides. The main body of the channel is also provided with two channel slides that are respectively connected to the two plate slides.

4. The sterile isolation and rearing chamber for laboratory animals according to claim 3, characterized in that, The transfer support plate is provided with a carrier plate rack parallel to the carrier plate slide, and the inside of the channel body is provided with a channel rack that can be connected to the carrier plate rack along its length direction. The forward drive unit includes a forward motor and two forward rotating shafts. The two forward rotating shafts are arranged in parallel between two lower sliding supports. The ends of the forward rotating shafts are rotatably connected to the side walls of the lower sliding supports. The output end of the forward motor is connected to the end of one of the forward rotating shafts. The two forward-moving shafts are also connected by a belt drive, and each forward-moving shaft is equipped with a forward-moving gear that can mesh with the carrier plate rack and the channel rack.

5. The sterile isolation and rearing chamber for laboratory animals according to claim 3, characterized in that, The two lower sliding supports have protruding strips on their opposite sidewalls, and the transfer support plate is provided with two abutting units located on the sides of the two lower sliding supports respectively. The clamping unit includes an upper top and a movable part; The top part can slide through the transfer support plate, the bottom of the top part is bent and connected to the bottom of the transfer support plate through a downward spring, the movable part is slidably disposed on the upper surface of the transfer support plate, the end of the movable part facing the lower sliding support has a supporting part, and the end of the movable part away from the lower sliding support is connected to the side of the transfer support plate through a release spring. The top of the upper part contacts the inclined surface of the lower surface of the movable part, and the bottom of the outer shell of the cabin has a bottom plate. When the load-bearing transfer component is located at the position corresponding to the transfer inlet / outlet, the top and bottom of the component abut against the bottom plate and move upward.

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