一种纳米抗体B11-E8-F3组合物及其制备方法
By preparing a nanobody composition B11-E8-F3 containing sugars, amino acids, surfactants, and protein stabilizers, the problem of insufficient stability of multivalent nanobodies at high temperatures was solved, and long-term stable storage and activity retention under high-temperature conditions were achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ACADEMY OF MILITARY MEDICAL SCIENCES
- Filing Date
- 2025-09-08
- Publication Date
- 2026-07-17
AI Technical Summary
The existing multivalent nanobody B11-E8-F3 has insufficient stability under high temperature conditions, which limits its further application. Existing stabilizers have problems such as poor temperature sensitivity, freeze-thaw instability, and decreased activity during long-term storage.
The multivalent nanobody B11-E8-F3 composition, containing sugars, amino acids, surfactants, and protein stabilizers, as well as pH buffers and osmotic pressure regulators, is prepared through a specific ratio and process to improve the high-temperature tolerance of the nanobody.
The stability of the multivalent nanobody B11-E8-F3 under high temperature conditions was significantly improved, its storage time was extended, and its binding activity was maintained.
Smart Images
Figure CN121015867B_ABST