A wet-adhesive hydrogel for inhibiting ferroptosis and a preparation method and application thereof

Abstract

The application discloses a wet adhesion hydrogel for inhibiting ferroptosis and a preparation method and application thereof, relates to the technical field of biomedical materials, and discloses the wet adhesion hydrogel for inhibiting ferroptosis, which takes nano clay as a physical crosslinking framework, takes hyaluronic acid as a main matrix material, takes dopamine as an adhesion functional component, and takes tannic acid as a secondary crosslinking agent and an iron ion chelation functional component; through step-by-step crosslinking, first, dopamine is grafted onto a hyaluronic acid molecular chain in the physical crosslinking framework provided by the nano clay through catalysis of an activator, then tannic acid is introduced through an indirect immersion method, secondary crosslinking is formed by using phenolic hydroxyl groups in tannic acid molecules and catechol groups, and iron ion chelation ability is provided through coordination of the phenolic hydroxyl groups and iron ions, so that the organic unity of structural stability, tissue adhesion and iron metabolism regulation function is realized, wound healing is promoted, and the problem of insufficient intervention of existing skin flap protection materials on a key mechanism of ferroptosis is solved.

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