与非洲猪瘟免疫相关的分子标记、引物、试剂盒及应用
By detecting SNP molecular markers at specific sites in the porcine ELK4 gene, the problem of individual differences in immune response after ASFV vaccination was solved, enabling efficient screening of ASFV-resistant breeding pigs, improving breeding efficiency and health levels, and reducing costs.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- YANGTZE UNIVERSITY
- Filing Date
- 2025-09-30
- Publication Date
- 2026-07-17
AI Technical Summary
In existing technologies, there are significant differences in individual immune responses after African swine fever virus vaccination, and there is a lack of effective molecular markers related to the ASFV antigen-specific CD8+ T cell level, which limits the breeding efficiency and health level of ASFV-resistant pig breeds.
A specific SNP molecular marker is provided, located at a specific site in the porcine ELK4 gene. Through PCR amplification and genotyping analysis, the level of ASFV antigen-specific CD8+ T cells in pigs can be identified. Specific primers and kits are designed for detection to screen breeding pigs with high resistance to African swine fever virus.
It has improved the efficiency of pig breeding, enhanced the disease resistance of the population, reduced unnecessary feeding and time costs, enriched the research and development resource library of ASFV vaccines, and improved the detection accuracy of ASFV antigen-specific CD8+ T cell levels.
Smart Images
Figure CN121023040B_ABST