一株高产EPA的重组菌株及其应用
By ARTP mutagenesis and gene modification of Schizochytrium sp. to remove the long-chain synthetic domain, a high-EPA-producing mutant strain, Schizochytrium sp. MA127, was screened out, solving the problem of low EPA yield and realizing the efficient industrial production of EPA.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- YUNNAN VITAYUAN BIOTECHNOLOGY CO LTD
- Filing Date
- 2025-09-03
- Publication Date
- 2026-07-17
AI Technical Summary
In existing technologies, the EPA content in Schizochytrium sp. fermentation products is low, resulting in a much higher price for EPA compared to DHA. How to increase EPA production is an important issue in industrial production.
The ARTP mutagenesis technique was used to physically mutate microbial cells, and mutant strains with excellent traits were screened out. By deleting long chain synthetic domains and genetically modifying the genes, a Schizochytrium sp. MA127 strain with high EPA production was selected.
It significantly increased EPA production, with the EPA:DHA ratio increasing from 1:9.3 to 1:1.6, and the total lipid content also increasing by 2.86 times. EPA production increased by 4.25 times, achieving the goal of efficient and high-yield EPA production.
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Figure CN121064970B_ABST