一种检测Hp生物标志物的pH响应型纳米酶SERS传感器的制备方法
By assembling gold-palladium nanorods (Au@PdNRs) on the inner wall of a capillary to construct a pH-responsive nanozyme SERS sensor, the problem of sample contamination during planar substrate detection was solved, achieving highly sensitive, rapid, and non-invasive Hp infection detection.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NANTONG HAIMEN DISTRICT PEOPLES HOSPITAL
- Filing Date
- 2025-08-22
- Publication Date
- 2026-07-17
AI Technical Summary
Existing technologies struggle to achieve highly sensitive, non-invasive, and rapid detection of Helicobacter pylori (Hp), and planar substrates are prone to sample contamination during testing, making them unsuitable for irregular samples.
Gold-palladium nanorods (Au@PdNRs) were synthesized using a seed growth method and assembled onto the inner wall of an aminated capillary to construct a pH-responsive nanoenzyme SERS sensor. The sensor indirectly detects urease content by adjusting the pH of the solution through the specific hydrolysis of urea by urease to generate NH3.
It achieves highly sensitive detection of urease within 20 minutes, with a detection limit of 6.09 U/L, good reproducibility and stability, and is suitable for point-of-care detection of Hp infection.
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Figure CN121068557B_ABST