Laser acupuncture therapeutic instrument for dry eye

CN121081853BActive Publication Date: 2026-10-16西安市中医医院 +1
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Patent Information

Application Number
CN202511203361.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Priority Date
2024-09-18
Filing Date
2025-08-27
Publication Date
2026-10-16
Estimated Expiration
2045-08-27

AI Technical Summary

Technical Problem

[0003]现有的激光针灸治疗仪普遍采用固定模板或手动定位方式,无法根据患者面部特征自动识别针灸穴位,存在位置偏差,影响疗效;同时,多数设备仅具备固定功率连续激光输出,无法模拟针刺的“提插”“捻转”及灸法的多样热刺激,刺激方式单调,治疗效果有限;最后,现有的激光针灸治疗仪不能实时补偿因患者面部移动造成的光斑偏移,也无法根据温度和功率反馈自动调节激光输出,易造成照射偏差或热量不均

Benefits of technology

1、本发明将人脸关键点识别与中医解剖比例模型相结合,通过图像采集模块获取患者面部图像,依次进行二维高斯滤波、Sobel梯度提取、非极大值抑制与LBP特征点识别,精准提取包括双眼内外角、眉尾和鼻翼等多个解剖关键点,并基于比例模型反推7个针灸穴位坐标,相较于现有技术中采用固定模板或经验性手动定位的方法,本发明可自动适配不同患者面部结构,显著提升了穴位定位的个体化精度与稳定性,避免因偏差引起的疗效波动,为标准化智能中医治疗提供了坚实基础。

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Abstract

The application discloses a dry eye laser acupuncture treatment instrument, firstly, an image acquisition module is combined with face key point detection and an eye circumference proportion model, which can automatically identify and locate seven key acupoints of Zhuanchu, Yuliuzi, Situzhongkong, Jingming and the like on the face of a patient, realizes individualized and high-precision acupoint positioning; secondly, a laser irradiation system with a liquid crystal spatial light modulator is configured, supports continuous and pulse double output modes, can simulate acupuncture "lifting and inserting", "twisting" and various moxibustion methods, and enhances physiological stimulation effect; finally, infrared depth perception and laser angle compensation control are fused, dynamic tracking of patient face movement and real-time light path adjustment are realized, laser continuous alignment to acupoints is ensured, and the problems of irradiation deviation and uneven heat caused by patient micro-motion are overcome. The device improves treatment targeting, stimulation effectiveness and operation stability, and provides a new technical path for intelligent traditional Chinese medicine treatment of dry eye.
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Description

Technical Field

[0001] This invention relates to the field of dry eye treatment technology, specifically to a laser acupuncture treatment device for dry eye. Background Technology

[0002] Dry eye syndrome, also known as keratoconjunctivitis sicca, is a common and complex eye disease caused by insufficient tear secretion, excessive evaporation, or abnormal tear composition. The incidence of dry eye is rising year by year worldwide, ranging from 5.5% to 33.7%, with women generally having a higher incidence than men. Dry eye syndrome has become a global problem that urgently needs to be solved.

[0003] Existing laser acupuncture devices generally use fixed templates or manual positioning methods, which cannot automatically identify acupuncture points based on the patient's facial features, resulting in positional deviations and affecting the therapeutic effect. At the same time, most devices only have a fixed power continuous laser output, which cannot simulate the "lifting and thrusting" and "twisting" of acupuncture or the diverse thermal stimulation of moxibustion, resulting in monotonous stimulation methods and limited therapeutic effects. Finally, existing laser acupuncture devices cannot compensate for the spot shift caused by the patient's facial movement in real time, nor can they automatically adjust the laser output based on temperature and power feedback, which can easily cause irradiation deviations or uneven heat distribution. Summary of the Invention

[0004] To address the aforementioned technical problems, this invention proposes a laser acupuncture treatment device for dry eye syndrome, thereby resolving the issues present in the prior art.

[0005] To achieve the above objectives, the present invention provides a laser acupuncture treatment device for dry eye syndrome, comprising: The acupoint detection device is composed of an image acquisition module, an image processing module, and an acupoint recognition module. The image acquisition module is used to acquire facial images of patients, the image processing module is used to perform edge detection and feature extraction on the facial images, and the acupoint recognition module is used to locate target acupoints based on key point features. A laser generator is used to provide a laser beam of a specific wavelength; An acupoint irradiation device is used to guide the laser beam generated by a laser generator to the patient's acupuncture points; A regulator is used to acquire the laser beam intensity and adjust the output power of the laser generator according to the laser beam intensity; The dynamic tracking module is used to monitor the positional changes of the patient's face during treatment and output compensation commands in real time based on the acupoint displacement. The control module is used to adjust the incident direction of the laser beam according to the compensation command.

[0006] Preferably, the image acquisition module uses a camera device to acquire the original image of the patient's face, denoted as... ,in, These are the horizontal and vertical coordinates of the pixels in the original image on the plane; To smooth the image and suppress acquisition noise, the two-dimensional Gaussian kernel function is first defined as follows: in, Gaussian kernel in lateral offset With longitudinal offset The weight value at the location; These are the horizontal and vertical coordinates relative to the center pixel within the convolution kernel; Let $\mathbf{a}$ be the standard deviation of the Gaussian distribution. Based on the two-dimensional Gaussian kernel function For the original image Perform two-dimensional Gaussian filtering: in, The grayscale value of the filtered image; The original pixel values ​​within the convolutional neighborhood; The radius of the convolution kernel; Based on the grayscale value of the filtered image The Sobel operator is used to calculate the horizontal and vertical gradient components separately to synthesize the pixel gradient intensity: in, For pixels The overall gradient strength; and The values ​​are the horizontal and vertical values, respectively, both obtained based on Sobel operator convolution. Based on the comprehensive gradient strength After nonmaximum suppression and double threshold hysteresis processing, the facial contour region is obtained. Within this region, a facial landmark detection method combining Local Binary Pattern (LBP) and geometric proportion constraints is used to extract key points, including the inner and outer corners of the eyes, the tails of the eyebrows, and the alar of the nose, forming a set. : in, This represents the set of coordinates of all detected facial key points; For the first The coordinates of the key points The total number of key points; The key points are input into a preset periocular anatomy model to calculate and output a set of acupuncture point coordinates required for dry eye treatment: in, This is the set of coordinates for all identified acupuncture points; For the first The horizontal and vertical coordinates of each acupuncture point; The total number of target acupoints.

[0007] Preferably, the laser generator includes a semiconductor laser, a laser fiber coupler, and a laser beam splitter; The semiconductor laser is used to generate a laser beam of a specific wavelength; The laser fiber coupler is used to transmit the laser beam of a specific wavelength into the optical fiber; The laser beam splitter is used to divide the laser beam into several beams, which are then directed to multiple acupuncture points.

[0008] Preferably, the wavelength of the laser beam is 600–1500 nm; The acupuncture points include Zanzhu, Yuyao, Sizhukong, Jingming, Chengqi, Sibai, and Yingxiang.

[0009] Preferably, the acupoint irradiation device includes an eye mask, a strap, a transmission optical fiber, and an irradiation head; The goggles are used to cover the patient's eyes and secure the irradiation head; The straps are adjustable elastic straps used to secure the eye mask to the eyes; The transmission optical fiber is used to transmit the laser beam; The irradiation head is used to irradiate the acupuncture points with the laser beam, and the irradiation head contains a liquid crystal spatial light modulator for controlling the laser beam.

[0010] Preferably, the regulator includes an STM32 microcontroller, a TEC and a temperature sensor, a fuzzy PID control unit, a drive circuit, an A / D converter, and a D / A converter; The STM32 microcontroller is used to run the PID fuzzy control algorithm and issue control commands. The TEC and temperature sensor are used to adjust the operating temperature of the laser and measure the surface temperature of acupoint tissues. The fuzzy PID control unit is used for precise temperature control of the semiconductor laser; The D / A converter is used to convert the control command into a control electrical signal; The driving circuit is used to transmit the control electrical signal; The A / D converter is used to convert temperature signals into digital signals.

[0011] Preferably, based on the set of acupuncture point coordinates During the treatment, the dynamic tracking module uses an infrared depth sensor to detect the real-time coordinates of each acupuncture point: in, A set of real-time coordinates; For time Time The horizontal and vertical coordinates of each acupuncture point; Based on the set of acupuncture point coordinates and the real-time coordinates of each acupuncture point, calculate the two-dimensional displacement vector of each acupuncture point: in, For the first The displacement vector of acupuncture point; For the first Acupuncture points at Displacement on the axis; For the first Acupuncture points at Displacement on the axis; A pixel-to-angle conversion coefficient is introduced to convert pixel displacement into an adjustment angle for the laser path: in, For the first The incident angle compensation vector for each beam; For the first A beam of light Angle adjustment amount in the axial direction; For the first A beam of light Angle adjustment amount in the axial direction; This is the conversion factor from pixel to horizontal angle; This is the conversion factor from pixel to vertical angle; Final output compensation instruction set: ; After receiving the set of compensation instructions, the control module will adjust the incident angle of the laser beam in the horizontal and vertical directions in real time according to the values ​​of each incident angle compensation vector.

[0012] Preferably, the dry eye laser acupuncture treatment device further includes a power module, which is used to supply power to the acupoint detection device, the laser generator, and the regulator.

[0013] Compared with the prior art, the present invention has the following advantages and technical effects: 1. This invention combines facial key point recognition with a traditional Chinese medicine anatomical proportion model. It acquires patient facial images through an image acquisition module, and then sequentially performs two-dimensional Gaussian filtering, Sobel gradient extraction, non-maximum suppression, and LBP feature point recognition to accurately extract multiple anatomical key points, including the inner and outer corners of the eyes, the eyebrow tails, and the nasal alae. Based on the proportion model, it inversely derives the coordinates of seven acupuncture points. Compared to existing technologies that use fixed templates or empirical manual positioning methods, this invention can automatically adapt to different patients' facial structures, significantly improving the individualized accuracy and stability of acupuncture point positioning, avoiding efficacy fluctuations caused by deviations, and providing a solid foundation for standardized intelligent traditional Chinese medicine treatment.

[0014] 2. This invention innovatively achieves dynamic control of the laser spot shape, energy distribution, and time curve by introducing a liquid crystal spatial light modulator and a switchable pulse / continuous laser mode. Based on this, it can accurately simulate different acupuncture operation sensations such as "heavy insertion-light lifting" and "light insertion-heavy lifting," and even reproduce moxibustion techniques such as gentle moxibustion, sparrow-pecking moxibustion, and rotary moxibustion. The modulated laser output spot can be transformed from a Gaussian shape to an approximately flat-top distribution, avoiding the problem of central burning and insufficient edge irradiation. This design not only enhances the clinical stimulation effect but also significantly improves the patient's subjective experience.

[0015] 3. This invention integrates a multi-level control system consisting of an infrared depth sensor, a real-time displacement compensation algorithm, and a fuzzy PID temperature control circuit. It can monitor and compensate for acupoint displacement caused by slight head movements during treatment. The system can calculate the two-dimensional displacement vector of each acupoint and output a laser beam incident angle adjustment command through a pixel-to-angle conversion coefficient. The control module adjusts the beam direction in real time according to this command to ensure the laser is always accurately aligned with the acupoint. Furthermore, the STM32-based fuzzy PID temperature control circuit collects laser intensity and acupoint temperature signals in real time and forms a closed-loop feedback to adjust the laser power, effectively preventing burns caused by uneven heat or power drift leading to ineffective irradiation. This significantly improves the safety and consistency of the treatment process. Attached Figure Description

[0016] The accompanying drawings, which form part of this application, are used to provide a further understanding of this application. The illustrative embodiments and descriptions of this application are used to explain this application and do not constitute an undue limitation of this application. In the drawings: Figure 1 This is a schematic diagram of the control principle of the laser acupuncture treatment device for dry eye syndrome according to an embodiment of the present invention; Figure 2 This is a flowchart illustrating the workflow of the laser acupuncture treatment device for dry eye syndrome according to an embodiment of the present invention.

[0017] Figure 3 This is a flowchart of the acupoint detection and dynamic tracking subsystem according to an embodiment of the present invention. Detailed Implementation

[0018] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. This application will now be described in detail with reference to the accompanying drawings and embodiments.

[0019] It should be noted that the steps shown in the flowchart in the accompanying drawings can be executed in a computer system such as a set of computer-executable instructions, and although a logical order is shown in the flowchart, in some cases the steps shown or described may be executed in a different order than that shown here.

[0020] like Figures 1-3 As shown, this embodiment provides a laser acupuncture treatment device for dry eye syndrome, including: The acupoint detection device is composed of an image acquisition module, an image processing module, and an acupoint recognition module. The image acquisition module is used to acquire facial images of patients, the image processing module is used to perform edge detection and feature extraction on the facial images, and the acupoint recognition module is used to locate target acupoints based on key point features.

[0021] The image acquisition module uses a camera device to acquire the original image of the patient's face, which is recorded as follows: ,in, These are the horizontal and vertical coordinates of the pixels in the original image on the plane; To smooth the image and suppress acquisition noise, the two-dimensional Gaussian kernel function is first defined as follows: in, Gaussian kernel in lateral offset With longitudinal offset The weight value at the location; These are the horizontal and vertical coordinates relative to the center pixel within the convolution kernel; Let $\mathbf{a}$ be the standard deviation of the Gaussian distribution. In this embodiment, the standard deviation of the Gaussian distribution Set to 1.0 pixels; Based on the two-dimensional Gaussian kernel function For the original image Perform two-dimensional Gaussian filtering: in, The grayscale value of the filtered image; The original pixel values ​​within the convolutional neighborhood; The radius of the convolution kernel; In this embodiment, the convolution kernel radius The value is 2; Based on the grayscale value of the filtered image The Sobel operator is used to calculate the horizontal and vertical gradient components separately to synthesize the pixel gradient intensity: in, For pixels The overall gradient strength; and The values ​​are in the horizontal and vertical directions, respectively, and are obtained based on Sobel operator convolution. This edge detection process is a well-known technique in the field and is only used to define the main facial contour area to provide constraints for subsequent key point detection. Based on the comprehensive gradient strength After nonmaximum suppression and double threshold hysteresis processing, the facial contour region is obtained. Within this region, a facial landmark detection method combining Local Binary Pattern (LBP) and geometric proportion constraints is used to extract key points, including the inner and outer corners of the eyes, the tails of the eyebrows, and the alar of the nose, forming a set. : in, This represents the set of coordinates of all detected facial key points; For the first The coordinates of the key points The total number of key points; The key points are input into a preset periocular anatomy model to calculate and output a set of acupuncture point coordinates required for dry eye treatment: in, This is the set of coordinates for all identified acupuncture points; For the first The horizontal and vertical coordinates of each acupuncture point; The total number of target acupoints; In this embodiment, the total number of target acupoints The value is 7.

[0022] Furthermore, a laser generator is used to provide a laser beam of a specific wavelength; The laser generator includes a semiconductor laser, a laser fiber coupler, and a laser beam splitter; The semiconductor laser is used to generate a laser beam of a specific wavelength; The laser fiber coupler is used to transmit the laser beam of a specific wavelength into the optical fiber; The laser beam splitter is used to divide the laser beam into several beams, which are then directed to the acupuncture points respectively. Furthermore, the wavelength of the laser beam is 600–1500 nm; The acupuncture points include Zanzhu, Yuyao, Sizhukong, Jingming, Chengqi, Sibai, and Yingxiang.

[0023] In this embodiment, the laser generator is driven by the system during the treatment process to distribute a stable laser beam of a specific wavelength to multiple target acupuncture points. After the semiconductor laser is started, it outputs a laser beam, which is efficiently coupled into the transmission fiber through a laser fiber coupler. The fiber port adopts a low-loss interface design to reduce energy attenuation. Before entering each independent fiber branch, the multiple laser beams distributed by the beam splitter pass through an optical power equalization component in sequence to ensure that the output power of each beam is consistent, thereby avoiding the problem of insufficient or excessive energy at some acupuncture points. To improve the flexibility of multi-point irradiation, the beam splitter adopts an adjustable splitting ratio design, which allows the power distribution between each output branch to be adjusted proportionally according to the differences in symptoms in different treatment areas. For example, when the symptoms around the patient's eye are more severe on one side, the splitting ratio can be adjusted to distribute higher energy to the corresponding acupoints on the other side, while maintaining the normal dose for the acupoints on the other side, thereby achieving a personalized irradiation plan.

[0024] In addition, to enhance the comfort and physiological stimulation effect during treatment, the laser beam can be operated in either continuous output or pulse modulation mode. In pulse mode, the output frequency and duty cycle of the laser beam can be adjusted within the system setting range, making the irradiation effect closer to the "lifting and inserting" or "twisting" sensation of acupuncture, thereby improving the clinical stimulation effect.

[0025] Furthermore, the acupoint irradiation device is used to guide the laser beam generated by the laser generator to the patient's acupuncture points; The acupoint irradiation device includes an eye mask, a strap, a transmission optical fiber, and an irradiation head. The goggles are used to cover the patient's eyes and secure the irradiation head; The straps are adjustable elastic straps used to secure the eye mask to the eyes; The transmission optical fiber is used to transmit the laser beam; The irradiation head is used to irradiate the acupuncture points with the laser beam, and the irradiation head contains a liquid crystal spatial light modulator for controlling the laser beam.

[0026] During simulated acupuncture: At the start of laser irradiation, a higher power is used to simulate the effect of "forceful insertion," ensuring that the laser energy penetrates to the appropriate depth of the acupoint. The power is then gradually reduced to simulate a "gentle lifting" motion.

[0027] At the start of laser irradiation, a low power is used, which is then gradually increased to simulate the effect of "light insertion," ensuring that the laser energy penetrates to the appropriate depth of the acupoint. The laser beam is then suddenly turned off to simulate a "lifting" motion.

[0028] The continuous laser output was changed to pulsed output, giving it a similar effect to needle twisting.

[0029] During simulated moxibustion: Based on simulated acupuncture, the irradiation area is increased to simulate moxibustion. Moxibustion is divided into gentle moxibustion, sparrow-pecking moxibustion and rotary moxibustion. In simulating gentle moxibustion, a lower power is used to irradiate acupoints. To address the issue of uneven heat distribution at the irradiation site due to the laser irradiation conforming to a Gaussian distribution, this embodiment uses a liquid crystal spatial light modulator to adjust the laser, making the laser evenly distributed and achieving a better moxibustion effect. The pecking motion is simulated by controlling the switch of the irradiation head. In simulated rotary moxibustion, the laser irradiation position is controlled by a liquid crystal spatial light modulator to achieve rotary moxibustion.

[0030] In this embodiment, in order to improve the stability of laser irradiation and patient comfort, the acupoint irradiation device adopts a combination of lightweight and flexible fixation in its structural design. The main body of the eye mask is made of soft material that meets medical standards, and a skin-friendly buffer layer is added to the contact surface to reduce the pressure on the eye area after wearing it for a long time. At the same time, the strap is designed to be adjustable, which can be precisely fixed according to different patient head shapes and eye socket positions, so that the irradiation head maintains a stable optical path positioning throughout the treatment cycle and avoids the light spot shift caused by slight head movements. The liquid crystal spatial light modulator inside the irradiation head is used to control the phase and intensity distribution of the laser beam in real time. Based on the principle of refractive index change of liquid crystal molecules under the action of an external electric field, the modulator can spatially modulate the incident beam according to the set voltage matrix, so that the laser emits a controllable energy distribution. By modulating the phase, the shape of the spot can be adjusted without changing the total energy, such as changing from a Gaussian distribution to an approximately flat-top distribution to reduce the overheating phenomenon in the center. By modulating the intensity, the energy can be evenly distributed among multiple sub-regions to ensure that different acupoint areas receive a consistent irradiation effect.

[0031] Furthermore, the regulator is used to acquire the laser beam intensity and adjust the output power of the laser generator according to the laser beam intensity; The regulator includes an STM32 microcontroller, a TEC and temperature sensor, a fuzzy PID control unit, a drive circuit, an A / D converter, and a D / A converter; The STM32 microcontroller is used to run the PID fuzzy control algorithm and issue control commands. The TEC and temperature sensor are used to adjust the operating temperature of the laser and measure the surface temperature of acupoint tissues. The fuzzy PID control unit is used for precise temperature control of the semiconductor laser; The D / A converter is used to convert the control command into a control electrical signal; The driving circuit is used to transmit the control electrical signal; The A / D converter is used to convert temperature signals into digital signals.

[0032] In this embodiment, the regulator plays a core role in regulating laser power and thermal stability during laser acupuncture treatment. The regulator collects the laser intensity signals of each output optical path in real time through the optical power detection unit, and combines the data fed back by the temperature sensor to form a set of corresponding monitoring parameters. After the parameters are processed by the STM32 microcontroller, adjustment instructions are generated for the semiconductor laser drive current and the thermoelectric cooler (TEC) working status. To reduce response delay, the regulator is equipped with a high-speed A / D converter and a D / A converter, which are responsible for digitizing the analog signals output by the temperature sensor and power detection unit, and converting the digital instructions generated by the microcontroller into electrical signals that can be recognized by the drive circuit, thereby realizing a closed-loop response for temperature control and power control. After receiving the control signal, the drive circuit can adjust the laser's operating current and the TEC's cooling power within milliseconds to maintain the laser beam intensity within the set range and ensure that the temperature rise of the tissue surface at the optical path terminal is within a safe threshold. In addition, the regulator can balance and correct the power deviation of multiple fiber optic branches. When uneven output power is detected in each branch, the microcontroller will adjust the current distribution strategy to make the output of each branch gradually become consistent, ensuring that multiple acupoints receive equivalent laser energy at the same time, thereby improving the consistency of treatment effect.

[0033] Furthermore, the dynamic tracking module is used to monitor the positional changes of the patient's face during treatment and output compensation commands in real time based on the acupoint displacement. The control module is used to adjust the incident direction of the laser beam according to the compensation command.

[0034] Based on the set of acupuncture point coordinates During the treatment, the dynamic tracking module uses an infrared depth sensor to detect the real-time coordinates of each acupuncture point: in, A set of real-time coordinates; For time Time The horizontal and vertical coordinates of each acupuncture point; Based on the set of acupuncture point coordinates and the real-time coordinates of each acupuncture point, calculate the two-dimensional displacement vector of each acupuncture point: in, For the first The displacement vector of acupuncture point; For the first Acupuncture points at Displacement on the axis; For the first Acupuncture points at Displacement on the axis; A pixel-to-angle conversion coefficient is introduced to convert pixel displacement into an adjustment angle for the laser path: in, For the first The incident angle compensation vector for each beam; For the first A beam of light Angle adjustment amount in the axial direction; For the first A beam of light Angle adjustment amount in the axial direction; This is the conversion factor from pixel to horizontal angle; This is the conversion factor from pixel to vertical angle; In this embodiment, the pixel-to-angle conversion coefficients in both the horizontal and vertical directions are calibrated to be... / pixel, but to maintain computational independence and adapt to different optical structures, they are still denoted as . and In other implementations, the values ​​of the two can differ, depending on the structure of the optical components and the imaging ratio. Final output compensation instruction set: ; Therefore, after receiving the set of compensation instructions, the control module will adjust the incident angle of the laser beam in the horizontal and vertical directions in real time according to the value of each incident angle compensation vector, so that the laser beam can be continuously and accurately aligned with the target acupoint position under real-time changes, ensuring the stability and accuracy of the illumination position during the treatment process, thereby improving the effectiveness and safety of laser acupuncture.

[0035] Furthermore, the dry eye laser acupuncture treatment device also includes a power module, which supplies power to the acupoint detection device, the laser generator, and the regulator.

[0036] In this embodiment, dry eye patients who met the inclusion criteria were selected from the ophthalmology outpatient department of Xi'an Traditional Chinese Medicine Hospital. Through a randomized controlled trial, they were divided into a sodium hyaluronate group, a regular acupuncture group, and a laser acupuncture group, with 20 patients in each group, for a total of 60 patients.

[0037] ① Sodium hyaluronate group: Patients were treated with sodium hyaluronate eye drops 4 times a day for 14 consecutive days.

[0038] ②Ordinary acupuncture group: Acupuncture at Zanzhu, Yuyao, Sizhukong, Jingming, Chengqi, Sibai, and Yingxiang points, once a day, for 14 consecutive days.

[0039] ③ Laser acupuncture group: The laser acupuncture treatment instrument (wavelength 650nm, output power 15mW) was used to irradiate the Zanzhu, Yuyao, Sizhukong, Jingming, Chengqi, Sibai and Yingxiang acupoints, once a day for 14 consecutive days.

[0040] The treatment effects are shown in Tables 1-5. Table 1 is a comparison table of subjective symptom scores before and after treatment in the three groups of patients; Table 2 is a comparison table of tear river height before and after treatment in the three groups of patients; Table 3 is a comparison table of tear film breakup time before and after treatment in the three groups of patients; Table 4 is a table of corneal fluorescein staining ratio before and after treatment in the three groups of patients; and Table 5 is a table of clinical efficacy evaluation after treatment in the three groups of patients.

[0041] Table 1 Note: 'a' indicates a significant difference compared to the sodium hyaluronate group.

[0042] Table 2 Note: 'a' indicates a significant difference compared to the sodium hyaluronate group.

[0043] Table 3 Note: 'a' indicates a significant difference compared to the sodium hyaluronate group.

[0044] Table 4 Table 5 In this embodiment, Tables 1-5 confirm that the laser acupuncture treatment device is safe and reliable, and can improve the subjective symptoms of dry eye patients, increase the tear river height, prolong the average tear film breakup time, and promote corneal epithelial repair. In clinical observation, the efficacy of the laser acupuncture group was comparable to that of the ordinary acupuncture group, and the treatment effects of both groups were superior to those of the sodium hyaluronate group.

[0045] The above are merely preferred embodiments of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. A laser acupuncture treatment device for dry eye syndrome, characterized in that, include: The acupoint detection device is composed of an image acquisition module, an image processing module, and an acupoint recognition module. The image acquisition module is used to acquire facial images of patients, the image processing module is used to perform edge detection and feature extraction on the facial images, and the acupoint recognition module is used to locate target acupoints based on key point features. A laser generator is used to provide a laser beam of a specific wavelength; An acupoint irradiation device is used to guide the laser beam generated by a laser generator to the patient's acupuncture points; A regulator is used to acquire the laser beam intensity and adjust the output power of the laser generator according to the laser beam intensity; The dynamic tracking module is used to monitor the positional changes of the patient's face during treatment and output compensation commands in real time based on the acupoint displacement. A control module is used to adjust the incident direction of the laser beam according to the compensation command; The image acquisition module uses a camera device to acquire the original image of the patient's face, which is recorded as... ,in, These are the horizontal and vertical coordinates of the pixels in the original image on the plane; To smooth the image and suppress acquisition noise, the two-dimensional Gaussian kernel function is first defined as follows: in, Gaussian kernel in lateral offset With longitudinal offset The weight value at the location; These are the horizontal and vertical coordinates relative to the center pixel within the convolution kernel; Let $\mathbf{a}$ be the standard deviation of the Gaussian distribution. Based on the two-dimensional Gaussian kernel function For the original image Perform two-dimensional Gaussian filtering: in, The grayscale value of the filtered image; The original pixel values ​​within the convolutional neighborhood; The radius of the convolution kernel; Based on the grayscale value of the filtered image The Sobel operator is used to calculate the horizontal and vertical gradient components separately to synthesize the pixel gradient intensity: in, For pixels The overall gradient strength; and The values ​​are the horizontal and vertical values, respectively, both obtained based on Sobel operator convolution. Based on the comprehensive gradient strength After nonmaximum suppression and double threshold hysteresis processing, the facial contour region is obtained. Within this region, a facial landmark detection method combining Local Binary Pattern (LBP) and geometric proportion constraints is used to extract key points, including the inner and outer corners of the eyes, the tails of the eyebrows, and the alar of the nose, forming a set. : in, This represents the set of coordinates of all detected facial key points; For the first The coordinates of the key points The total number of key points; The key points are input into a preset periocular anatomy model to calculate and output a set of acupuncture point coordinates required for dry eye treatment: in, This is the set of coordinates for all identified acupuncture points; For the first The horizontal and vertical coordinates of each acupuncture point; The total number of target acupoints.

2. The laser acupuncture treatment device for dry eye syndrome according to claim 1, characterized in that, The laser generator includes a semiconductor laser, a laser fiber coupler, and a laser beam splitter; The semiconductor laser is used to generate a laser beam of a specific wavelength; The laser fiber coupler is used to transmit the laser beam of a specific wavelength into the optical fiber; The laser beam splitter is used to divide the laser beam into several beams, which are then directed to multiple acupuncture points.

3. The laser acupuncture treatment device for dry eye syndrome according to claim 1, characterized in that, The wavelength of the laser beam is 600–1500 nm; The acupuncture points include Zanzhu, Yuyao, Sizhukong, Jingming, Chengqi, Sibai, and Yingxiang.

4. The laser acupuncture treatment device for dry eye syndrome according to claim 1, characterized in that, The acupoint irradiation device includes an eye mask, a strap, a transmission optical fiber, and an irradiation head. The goggles are used to cover the patient's eyes and secure the irradiation head; The straps are adjustable elastic straps used to secure the eye mask to the eyes; The transmission optical fiber is used to transmit the laser beam; The irradiation head is used to irradiate the acupuncture points with the laser beam, and the irradiation head contains a liquid crystal spatial light modulator for controlling the laser beam.

5. A laser acupuncture treatment device for dry eye syndrome according to claim 1, characterized in that, The regulator includes an STM32 microcontroller, a TEC and temperature sensor, a fuzzy PID control unit, a drive circuit, an A / D converter, and a D / A converter; The STM32 microcontroller is used to run the PID fuzzy control algorithm and issue control commands. The TEC and temperature sensor are used to adjust the operating temperature of the laser and measure the surface temperature of acupoint tissues. The fuzzy PID control unit is used for precise temperature control of the semiconductor laser; The D / A converter is used to convert the control command into a control electrical signal; The driving circuit is used to transmit the control electrical signal; The A / D converter is used to convert temperature signals into digital signals.

6. The laser acupuncture treatment device for dry eye syndrome according to claim 1, characterized in that, Based on the set of acupuncture point coordinates During the treatment, the dynamic tracking module uses an infrared depth sensor to detect the real-time coordinates of each acupuncture point: in, A set of real-time coordinates; For time Time The horizontal and vertical coordinates of each acupuncture point; Based on the set of acupuncture point coordinates and the real-time coordinates of each acupuncture point, calculate the two-dimensional displacement vector of each acupuncture point: in, For the first The displacement vector of acupuncture point; For the first Acupuncture points at Displacement on the axis; For the first Acupuncture points at Displacement on the axis; A pixel-to-angle conversion coefficient is introduced to convert pixel displacement into an adjustment angle for the laser path: in, For the first The incident angle compensation vector for each beam; For the first A beam of light Angle adjustment amount in the axial direction; For the first A beam of light Angle adjustment amount in the axial direction; This is the conversion factor from pixel to horizontal angle; This is the conversion factor from pixel to vertical angle; Final output compensation instruction set: ; After receiving the set of compensation instructions, the control module will adjust the incident angle of the laser beam in the horizontal and vertical directions in real time according to the values ​​of each incident angle compensation vector.

7. The laser acupuncture treatment device for dry eye syndrome according to claim 1, characterized in that, The dry eye laser acupuncture treatment device also includes a power module, which is used to supply power to the acupoint detection device, the laser generator and the regulator.

Citation Information

Patent Citations

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