A male oil-control acne-removing composition and application thereof

Abstract

The present application relates to a kind of male oil control acne-removing composition and its application, the composition includes the following components: bixa orellana seed extract, pseudomonas ferment extract, phellodendron amurense bark extract, cynara scolymus leaf extract and magnolia kobus extract, the weight ratio of bixa orellana seed extract, pseudomonas ferment extract, phellodendron amurense bark extract, cynara scolymus leaf extract and magnolia kobus extract is (0.05-2) :(0.5-2) :(0.2-1) :(0.2-5) :(0.1-5). The oil control acne-removing composition of the present application can relieve the acne problem of men from oil control, antibacterial, anti-inflammatory, repair, moisturizing and other aspects by the synergy of five ingredients.

Description

Technical Field

[0001] This invention relates to the field of oil-controlling and acne-removing cosmetics technology, specifically to an oil-controlling and acne-removing composition for men and its application. Background Technology

[0002] In recent years, men's awareness of skincare has gradually increased, but they still mainly focus on cleansing products and pay insufficient attention to skincare such as oil control and acne treatment.

[0003] There are significant differences in the physiological structure and microecological composition of male and female skin. Studies have shown that men's average sebum secretion is twice as high as that of women, and their moisture loss is 25% higher. Most current acne treatment products are general formulas, which mainly work by reducing sebum secretion, inhibiting excessive keratinization of the hair follicle stratum corneum, inhibiting the proliferation of Propionibacterium acnes in the sebaceous glands, anti-inflammation, and regulating the microecology. They have not been optimized for men's higher sebum secretion levels and the barrier damage caused by shaving.

[0004] Therefore, in addition to considering the oil-controlling and acne-reducing effects, men's oil-controlling and acne-reducing products also need to take into account issues such as barrier damage caused by shaving and other procedures. Summary of the Invention

[0005] The purpose of this invention is to overcome the shortcomings of the prior art and provide a men's oil-controlling and acne-removing composition and its application.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows: In a first aspect, the present invention provides an oil-controlling and acne-removing composition for men, comprising the following components: rosewood seed extract, *Pseudomonas aeruginosa* fermentation product extract, *Phellodendron amurense* bark extract, *Artichoke leaf* extract, and *Magnolia sieboldii* extract, wherein the weight ratio of the rosewood seed extract, *Pseudomonas aeruginosa* fermentation product extract, *Phellodendron amurense* bark extract, *Artichoke leaf* extract, and *Magnolia sieboldii* extract is (0.05-2):(0.5-2):(0.2-1):(0.2-5):(0.1-5).

[0007] The functions of each component in the composition of the present invention are as follows: Rosewood seed extract can reduce sebaceous gland activity, thereby controlling oil production at its source by limiting excessive lipid production. Furthermore, it can block the IGF-1 signaling pathway in keratinocytes, inhibiting its binding to receptors and thus suppressing sebaceous gland cell proliferation, reducing sebaceous gland activity, and decreasing sebum secretion. Additionally, rosewood seed extract can help maintain skin hydration.

[0008] The fermentation product extract of *Pseudomonas alterniflora* can reduce the content of melanocortin receptor 5 (MC5-R), which is associated with sebaceous gland cell differentiation, thereby reducing the accumulation of sebaceous lipids in differentiated sebaceous gland cells and slowing down the maturation of sebaceous gland cells.

[0009] Phellodendron bark extract has a significant antibacterial effect against Propionibacterium acnes, which can reduce inflammation caused by acne, accelerate wound healing, and eliminate acne.

[0010] The active substances in artichoke leaf extract can effectively inhibit the activation of NF-κB, thereby reducing inflammatory responses. In addition, most of the active substances, such as polyphenols and ketones, have strong antioxidant properties, which can effectively scavenge free radicals and reduce skin damage caused by oxidative stress. Furthermore, polyphenolic active substances can also promote the synthesis of collagen in the skin, enhancing skin elasticity and firmness.

[0011] Magnolia officinalis extract contains rich moisturizing ingredients that can increase the skin's moisture content, enhance its water retention capacity, and keep the skin hydrated.

[0012] Preferably, the weight ratio of the rosewood seed extract, the *Pseudomonas aeruginosa* fermentation product extract, the *Phellodendron amurense* bark extract, the *Artichoke* leaf extract, and the *Magnolia denudata* extract is (0.1-0.5):(0.8-1.5):(0.3-0.8):(3-5):(1-5).

[0013] Most preferably, the weight ratio of the rosewood seed extract, the *Pseudomonas aeruginosa* fermentation product extract, the *Phellodendron amurense* bark extract, the *Artichoke* leaf extract, and the *Magnolia denudata* extract is 0.2:1:0.5:2:2.

[0014] Preferably, the rosewood seed extract is purchased from Xi'an Tiankang Biotechnology Co., Ltd.

[0015] Preferably, the Pseudomonas aeruginosa fermentation product extract was purchased from Lipotec.

[0016] Preferably, the Phellodendron bark extract was purchased from Guangzhou Heji Biotechnology Co., Ltd.

[0017] Preferably, the artichoke leaf extract is purchased from Zhenghe (Guangzhou) Biotechnology Co., Ltd.

[0018] Preferably, the Magnolia officinalis extract was purchased from Guangzhou Jinbaolai Biotechnology Co., Ltd.

[0019] Secondly, the present invention provides the application of the men's oil-controlling and acne-removing composition of the first aspect in the preparation of cosmetics.

[0020] Preferably, the cosmetic is one of toner, lotion, cream, mask and serum, and the amount of the men's oil-controlling and acne-removing composition added is 2%-8% of the total weight of the cosmetic.

[0021] Thirdly, the present invention provides an oil-controlling and acne-removing lotion comprising the following ingredients by weight percentage: 2%-8% of the men's oil-controlling and acne-removing composition of the first aspect, 4%-8% of moisturizer, 0.1%-0.3% of thickener, 0.03%-0.1% of chelating agent, 5%-8% of emulsifier, 0.5%-2% of preservative, 0.01%-0.3% of pH adjuster, and the balance being deionized water.

[0022] Preferably, the moisturizer is at least one selected from allantoin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, D-panthenol, sodium hyaluronate, 1,2-butanediol, glycerol, budding stalk polysaccharide, and ceramide.

[0023] Preferably, the thickener is at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer, and sclerotium gum.

[0024] Preferably, the chelating agent is EDTA-2Na.

[0025] Preferably, the emulsifier is at least one of the following: coconut oil alcohol-caprylate / capric acid ester, polydimethylsiloxane, hydrogenated palm kernel oil, cetearyl alcohol, polyglycerol-6 distearate, and polymethylsilsesquioxane.

[0026] Preferably, the preservative is at least one selected from 1,3-propanediol, 1,2-hexanediol, and p-hydroxyacetophenone.

[0027] Preferably, the pH adjuster is at least one of arginine, tromethamine, and disodium EDTA.

[0028] Fourthly, the present invention provides a method for preparing the oil-controlling and acne-removing lotion of the third aspect, comprising the following steps: S1. Mix the humectant, thickener, chelating agent and deionized water, and homogenize at 75-85℃ to obtain the aqueous phase; S2. Homogenize the emulsifier at 75-85℃ to obtain the oil phase; S3. Stir the aqueous phase and oil phase evenly, and add the preservative after cooling to 55-65℃. Stir evenly, and add each component of the men's oil-controlling and acne-removing composition after the temperature drops to 35-45℃. Stir evenly, and finally add the pH adjuster to adjust the pH to obtain the oil-controlling and acne-removing lotion.

[0029] Compared with the prior art, the beneficial effects of the present invention are as follows: The redwood seed extract and *Pseudomonas aeruginosa* fermentation product extract in the men's oil-controlling and acne-removing composition of this invention have a synergistic effect, reducing sebum secretion by inhibiting sebaceous gland cell proliferation and slowing down sebaceous gland cell maturation. The *Phellodendron amurense* bark extract can specifically kill *Propionibacterium acnes*, eliminating the root cause of acne. Simultaneously, the artichoke leaf extract rapidly inhibits bacterial-induced inflammatory responses by inhibiting the NF-κB pathway. The synergistic effect of these two ingredients effectively prevents and reduces red and swollen acne, avoiding pigmentation and scarring. In addition to its anti-inflammatory effects, the polyphenols in the artichoke leaf extract promote collagen synthesis and have a repairing effect. The *Magnolia officinalis* extract has a strong moisturizing effect, enhancing the skin's water retention capacity and creating a good hydration environment for repair. The synergistic effect of these two ingredients enhances the repairing effect of the composition and alleviates barrier damage caused by shaving and other procedures in men. Therefore, the men's oil-controlling and acne-removing composition of this invention, through the synergistic effect of these five ingredients, can alleviate men's acne problems from multiple aspects, including oil control, antibacterial, anti-inflammatory, repair, and moisturizing. Detailed Implementation

[0030] To better illustrate the purpose, technical solution, and advantages of the present invention, the present invention will be further described below in conjunction with specific embodiments.

[0031] The sources of the raw materials used in the following examples and comparative examples are as follows: Rosewood seed extract: purchased from Xi'an Tiankang Biotechnology Co., Ltd.; Pseudomonas alterniflora fermentation product extract: purchased from Lipotec; Phellodendron bark extract: purchased from Guangzhou Heji Biotechnology Co., Ltd.; Artichoke leaf extract: purchased from Zhenghe (Guangzhou) Biotechnology Co., Ltd.; Magnolia officinalis extract: purchased from Guangzhou Jinbaolai Biotechnology Co., Ltd.

[0032] Unless otherwise specified, all other materials and reagents used in the examples are commercially available.

[0033] Examples 1-5 and Comparative Examples 1-5 The composition (mass ratio) of the men's oil-controlling and acne-removing compositions of Examples 1-5 and Comparative Examples 1-5 is shown in Table 1. The total mass parts of each composition are 100 parts.

[0034] Table 1. Formulations of oil-controlling and acne-removing compositions for men in each group.

[0035] The preparation methods of the oil-controlling and acne-removing compositions for men in Examples 1-5 and Comparative Examples 1-5 include the following steps: The composition is obtained by mixing the ingredients in the specified amounts evenly.

[0036] Test Example 1: Experiment on the inhibition of sebum synthesis in different groups of men using the oil-controlling and acne-removing composition. (1) Solution preparation: Test sample preparation: Take 0.10 mL of the composition samples of Examples 1-5 and Comparative Examples 1-5 respectively, and add 0.90 mL of sodium pyruvate-free DMEM (Gibco, C11965500BT) culture medium to prepare a 10% stock solution; Preparation of hydrocortisone solution: Weigh 0.01 g of hydrocortisone (Shanghai Yuanye Biotechnology, S31360) and add 1 mL of methanol to prepare a 10 mg / mL stock solution. Preparation of isotretinoin solution: Weigh 0.01 g of isotretinoin (Shanghai Dibai Biotechnology, H573005) and add 1 mL of methanol to prepare a 10 mg / mL stock solution; Culture medium: Take 10 mL of fetal bovine serum FBS (Macklin, F917980) and add 90 mL of DMEM culture medium to prepare DMEM medium without sodium pyruvate containing 10% FBS. Maintenance medium: Take 1 mL of fetal bovine serum (FBS) and add 99 mL of DMEM culture medium to prepare a sodium pyruvate-free DMEM medium containing 1% FBS. PBS buffer: purchased from Gibco, catalog number C10010500BT.

[0037] (2) Experimental grouping: Negative control group (NT): Maintenance culture medium; Model group (M): maintenance culture medium + 10 ng / mL hydrocortisone; Positive control group (PC): 0.01 mM isotretinoin + maintenance culture medium + 10 ng / mL hydrocortisone; Sample group (TA): 0.001% sample + maintenance culture medium + 10 ng / mL hydrocortisone; (3) Quantitative fluorescence assay for neutral lipids: The cell line used was human sebaceous gland cells SZ95 (Shanghai Qingqi Biotechnology, BFN60807569), passaged 7 times. The testing conditions were: incubator temperature 37±1℃, humidity 90±5%, carbon dioxide 5±1%. The cell suspension was seeded into 96-well cell culture plates (black bottom transparent type) at a density of 1.0 × 10⁶ cells per well. 4 Add 100 μL of culture medium to each well and incubate for 18-24 h to allow the cells to adhere to the well. Discard the supernatant, and add 100 μL of the required components for the negative control group, positive control group, model group, and sample group according to the above experimental groups, with 3 replicates per well; Table 2. Experimental protocol for inhibiting sebum secretion

[0038] After incubation for 48 h, the supernatant was discarded, and the samples were washed twice with PBS. As shown in Table 2, 100 μL of 10 μg / mL Nile Red dye (Shanghai Yuanye Biotechnology, S02N11G129713) was added to the quantitative fluorescence experimental group, while 15 μg / mL of fluorescein diacetate (FDA) (Shanghai Yuanye Biotechnology, J22A11H122040) was added to the quantitative fluorescence control group. After incubation for 5 min, the released fluorescence was detected on a multi-functional microplate reader. Excitation wavelengths of 485 nm and 494 nm and absorption wavelengths of 565 nm and 523 nm were used to detect the fluorescence intensity of Nile Red and FDA, respectively. The results were determined using the ratio of Nile Red to FDA (OD ratio). The percentage of intracellular neutral lipids (%) = OD ratio of experimental group / OD ratio of control group × 100%. The relative neutral lipid content (%) = percentage of neutral lipids / percentage of neutral lipids in model control group × 100%. Specific data are shown in Table 3.

[0039] Table 3. Data on the improvement rate of sebum secretion in each group of samples. Example 1 61.7 Example 2 70.4 Example 3 65.1 Example 4 74.7 Example 5 72.1 Comparative Example 1 80.4 Comparative Example 2 83.0 Comparative Example 3 87.6 Comparative Example 4 92.2 Comparative Example 5 95.4 Negative control group (NT) 59.6 Model control group (M) 100 Positive control group (PC) 82.6 The intracellular neutral lipid content directly corresponds to the amount of lipid synthesis; a higher content means more lipid is produced by the cells. If the percentage of neutral lipids in the sample group is lower than that in the model group, it indicates that the sample inhibits lipid synthesis; the lower the percentage, the stronger the lipid control effect. Conversely, a higher percentage indicates a weaker or no lipid control effect.

[0040] As shown in Table 3, and in conjunction with the data from Examples 1-5, when the weight ratio of the rosewood seed extract, *Pseudomonas aeruginosa* fermentation product extract, *Phellodendron amurense* bark extract, *Artichoke leaf* extract, and *Magnolia denudata* extract is (0.1-0.5):(0.8-1.5):(0.3-0.8):(3-5):(1-5), the oil-controlling effect of the composition is at a relatively good level.

[0041] Based on the data from Example 1 and Comparative Examples 1-5, it is evident that the absence of any single component in the composition reduces its oil-controlling properties. This may be because the extracts of rosewood seeds, *Pseudomonas aeruginosa* fermentation product, *Phellodendron amurense* bark, *Artichoke leaf*, and *Magnolia denudata* synergistically inhibit sebum secretion. In particular, the rosewood seed extract and *Pseudomonas aeruginosa* fermentation product extract exhibit a significant synergistic effect, reducing sebum secretion by inhibiting sebaceous gland cell proliferation and slowing down sebaceous gland cell maturation.

[0042] Test Example 2: Inhibition rate test of Propionibacterium acnes in each group of compositions Experimental Methods: Liquid thioglycolate medium (FT medium, Huankai Microbiology, REF: 028033) was prepared. 0.2 wt% *Propionibacterium acnes* (Guangdong Provincial Institute of Microbiology) was inoculated into the medium and cultured at 37°C for 48 h to form a bacterial suspension. The test samples (the oil-controlling and acne-removing compositions for men in Examples 1-5 and Comparative Examples 1-5) were mixed with DMSO to prepare a sample solution with a volume percentage of 0.01%. 180 μL of the bacterial suspension was added to a 96-well plate, followed by 40 μL of each sample solution to form a sample group. A control group (bacterial suspension without sample solution) was also set up. After culturing for 24 h, the OD value of each well was measured using a microplate reader. A lower OD value indicates clearer liquid, lower bacterial activity, and better antibacterial effect. The antibacterial rate was calculated using the following formula: Antibacterial rate (%) = (OD value of control group - OD value of sample group) / OD value of control group × 100%; specific data are shown in Table 4.

[0043] Table 4. Inhibition rate data of Propionibacterium acnes in each group of samples Example 1 91.5 Example 2 89.4 Example 3 92.1 Example 4 85.3 Example 5 83.9 Comparative Example 1 70.5 Comparative Example 2 72.7 Comparative Example 3 62.5 Comparative Example 4 58.4 Comparative Example 5 74.8 As shown in Table 4, and in conjunction with the data from Examples 1-5, the composition exhibits a better inhibitory effect on Propionibacterium acnes when the weight ratio of the rosewood seed extract, Pseudomonas aeruginosa fermentation product extract, Phellodendron amurense bark extract, Artichoke leaf extract, and Magnolia officinalis extract is (0.1-0.5):(0.8-1.5):(0.3-0.8):(3-5):(1-5).

[0044] Based on the data from Example 1 and Comparative Examples 1-5, it can be seen that the absence of any one component in the composition reduces the oil-controlling performance of the composition. This may be because the extracts of redwood seed, pseudoalteromonas fermentation product, phellodendron bark, artichoke leaf, and magnolia extract have a good synergistic effect on inhibiting Propionibacterium acnes. In particular, the phellodendron bark extract can specifically kill Propionibacterium acnes, eliminating the root cause of acne. At the same time, artichoke leaf extract can rapidly inhibit the inflammatory response caused by bacteria by inhibiting the NF-κB pathway. The synergy of the two can effectively prevent and reduce red and swollen acne, and avoid pigmentation and scar formation.

[0045] Application Example 1-5 and Comparative Application Example 1-5 The compositions of Examples 1-5 and Comparative Examples 1-5 were added to the oil-controlling and acne-removing lotion at a concentration of 5 wt% to obtain the lotions of Application Examples 1-5 and Comparative Application Examples 1-5. The formulations are shown in Table 5.

[0046] The preparation method of the oil-controlling and acne-reducing lotion of Application Examples 1-5 and Comparative Application Examples 1-5 includes the following steps: S1. Mix the humectant, thickener, chelating agent and deionized water, and homogenize at 80℃ and 1200rpm for 5min to obtain the aqueous phase; S2. Mix all components of the emulsifier and homogenize at 80℃ and 1200rpm for 5 minutes to obtain the oil phase; S3. Stir the aqueous phase and oil phase evenly at 80°C. After cooling to 60°C, add the preservative and stir evenly at 300 rpm. When the temperature of the mixture drops to 40°C, add the components of the men's oil-controlling and acne-removing composition and continue stirring for 5 minutes. Finally, add the pH adjuster to adjust the pH to obtain the oil-controlling and acne-removing lotion.

[0047] Table 5. Formulations of the oil-controlling and acne-reducing lotions in Application Examples 1-5 and Comparative Application Examples 1-5

[0048] Comparative Application Example 6 Compared to Application Example 6, the lotion did not contain the men's oil-controlling and acne-removing composition, but instead used an equal amount of deionized water instead of the men's oil-controlling and acne-removing composition. The preparation method was the same as in Application Example 1.

[0049] Test Example 3: Test on the acne-clearing and repairing effects of each group of lotions on the human body Screening criteria: We are recruiting volunteers with mild acne on their face (e.g., ≤10 papules or pustules) and independent acne scars with a diameter ≥3mm.

[0050] Transdermal water loss (TEWL) value ≥20 g / m²·h (measured using Tewameter™ Hex).

[0051] Exclusion criteria: Individuals who have recently (within 1 month) used hormonal drugs, anti-acne drugs, or undergone facial cosmetic treatments; individuals who are allergic to the components of the test sample; pregnant or breastfeeding women.

[0052] Grouping and Number of People: Eligible volunteers were randomly divided into 11 groups (Application Examples 1-5 and Comparative Application Examples 1-6), with 5 people in each group.

[0053] (3) Sample application method Test samples: emulsions prepared in Application Examples 1-5 and Comparative Application Examples 1-6 (double-blind method numbering), wherein the emulsion prepared in Comparative Application Example 6 is the blank control group, and the other application examples and comparative application examples are the sample groups.

[0054] How to use: After cleansing in the morning and evening, volunteers should take 1mL of the sample and apply it evenly to the entire face, gently massaging until fully absorbed.

[0055] (4) Testing cycle and process Test period: 14 days (D0, D...) 14 ).

[0056] Visit time points: D0 (baseline period), D 14 (At the end of the test) Instrument testing will be conducted.

[0057] Preparation before testing: a) After the participants arrived, they used a uniform, non-irritating facial cleanser to clean their faces. b) Rest for 30 minutes in a constant temperature and humidity environment (temperature 21±1℃, humidity 50±10%); c) Keep your eyes closed and relax during the test to avoid facial expressions and movements that may interfere with the process.

[0058] (5) Test indicators Acne-removing effects: The VISIA-CR facial image analyzer was used to quantify and photograph the qualitative changes in facial acne, and the number of acne lesions was counted. Repairing and redness-reducing effects: The TEWL value of the skin surface and facial erythema were measured using the Tewameter™ Hex and MX 18 to evaluate the skin barrier repair effect and redness reduction effect.

[0059] The test product was used to assess the facial skin condition 14 days after application, in order to comprehensively evaluate the product's efficacy in acne removal, redness reduction, and repair.

[0060] The calculation formulas for each evaluation parameter are as follows: Improvement rate (%) of each indicator = (mean before use - mean after use) / mean before use × 100%; data are shown in Table 6.

[0061] Table 6. Human test data results for each group of emulsions Application Example 1 45.0 31.8 40.1 Application Example 2 39.5 31.1 33.4 Application Example 3 41.9 30.2 37.4 Application Example 4 34.9 28.5 28.5 Application Example 5 36.4 26.0 30.2 Comparative Application Example 1 16.3 13.2 15.5 Comparative Application Example 2 19.1 14.3 18.3 Comparative Application Example 3 22.7 12.7 13.2 Comparative Application Example 4 25.6 10.6 11.2 Comparative Application Example 5 29.3 9.7 9.8 Comparative Application Example 6 7.5 6.8 7.3 As shown in Table 6, each lotion showed improved acne-removing and repairing effects compared to the control group (the blank control group without the added composition) lotion.

[0062] Based on the data from Application Examples 1-5, it can be seen that when the weight ratio of the redwood seed extract, Pseudomonas aeruginosa fermentation product extract, Phellodendron amurense bark extract, Artichoke leaf extract, and Magnolia sieboldii extract is (0.1-0.5):(0.8-1.5):(0.3-0.8):(3-5):(1-5), the lotion has a better effect on acne removal and repair.

[0063] Based on the data from Application Example 1 and Comparative Application Examples 1-5, it can be seen that the oil-controlling performance of the composition is reduced if any one of the ingredients is missing. This may be because the present invention can alleviate men's acne problems from multiple aspects such as oil control, antibacterial, anti-inflammatory, repair, and moisturizing through the synergistic effect of redwood seed extract, Pseudomonas aeruginosa fermentation product extract, Phellodendron amurense bark extract, Artichoke leaf extract, and Magnolia sieboldii extract.

[0064] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the essence and scope of the technical solutions of the present invention.

Claims

1. A composition for controlling oil and treating acne in men, characterized in that, It comprises the following components: rosewood seed extract, *Pseudomonas aeruginosa* fermentation product extract, *Phellodendron amurense* bark extract, *Cirsium japonicum* leaf extract, and *Magnolia sieboldii* extract, wherein the weight ratio of the rosewood seed extract, *Pseudomonas aeruginosa* fermentation product extract, *Phellodendron amurense* bark extract, *Cirsium japonicum* leaf extract, and *Magnolia sieboldii* extract is (0.05-2):(0.5-2):(0.2-1):(0.2-5):(0.1-5).

2. The oil-controlling and acne-removing composition for men as described in claim 1, characterized in that, The weight ratio of the rosewood seed extract, the Pseudomonas aeruginosa fermentation product extract, the Phellodendron amurense bark extract, the artichoke leaf extract, and the Magnolia sieboldii extract is (0.1-0.5):(0.8-1.5):(0.3-0.8):(3-5):(1-5).

3. The oil-controlling and acne-removing composition for men as described in claim 1, characterized in that, The weight ratio of the rosewood seed extract, *Pseudomonas aeruginosa* fermentation product extract, *Phellodendron amurense* bark extract, *Artichoke leaf* extract, and *Magnolia denudata* extract is 0.2:1:0.5:2:

2.

4. The oil-controlling and acne-removing composition for men as described in claim 1, characterized in that, The source of the component is selected from at least one of (I)-(V): (I) The rosewood seed extract was purchased from Xi'an Tiankang Biotechnology Co., Ltd.; (II) The Pseudomonas alterniflora fermentation product extract was purchased from Lipotec. (III) The Phellodendron bark extract was purchased from Guangzhou Heji Biotechnology Co., Ltd.; (IV) The artichoke leaf extract was purchased from Zhenghe (Guangzhou) Biotechnology Co., Ltd.; (V) Magnolia officinalis extract was purchased from Guangzhou Jinbaolai Biotechnology Co., Ltd.

5. The use of the men's oil-controlling and acne-removing composition according to any one of claims 1-4 in the preparation of cosmetics.

6. The application of the men's oil-controlling and acne-removing composition as described in claim 5 in the preparation of cosmetics, characterized in that, The cosmetic is one of the following: toner, lotion, cream, mask, and serum. The amount of the men's oil-controlling and acne-removing composition added is 2%-8% of the total weight of the cosmetic.

7. An oil-controlling and acne-removing lotion, characterized in that, The ingredients comprise the following ingredients by weight percentage: 2%-8% of the men's oil-controlling and acne-removing composition according to any one of claims 1-4, 4%-8% of moisturizer, 0.1%-0.3% of thickener, 0.03%-0.1% of chelating agent, 5%-8% of emulsifier, 0.5%-2% of preservative, 0.01%-0.3% of pH adjuster, and the balance being deionized water.

8. The oil-controlling and acne-removing lotion as described in claim 7, characterized in that, The raw material is selected from at least one of (a)-(f): (a) The moisturizer is at least one of allantoin, betaine, β-glucan, trehalose, caprylyl glycol, dipropylene glycol, D-panthenol, sodium hyaluronate, 1,2-butanediol, glycerin, budding stalk polysaccharide and ceramide; (b) The thickener is at least one of xanthan gum, carbomer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, ammonium acryloyldimethyl taurate / VP copolymer and sclerotium gum; (c) The chelating agent is EDTA-2Na; (d) The emulsifier is at least one of the following: coconut oil alcohol-caprylate / capric acid ester, polydimethylsiloxane, hydrogenated palm kernel oil, cetearyl alcohol, polyglycerol-6 distearate, and polymethylsilsesquioxane; (e) The preservative is at least one of 1,3-propanediol, 1,2-hexanediol and p-hydroxyacetophenone; (f) The pH adjuster is at least one of arginine, tromethamine, and disodium EDTA; 9. The preparation method of the oil-controlling and acne-removing lotion according to claim 8, characterized in that, Includes the following steps: S1. Mix the humectant, thickener, chelating agent and deionized water, and homogenize at 75-85℃ to obtain the aqueous phase; S2. Homogenize the emulsifier at 75-85℃ to obtain the oil phase; S3. Stir the aqueous phase and oil phase evenly, and add the preservative after cooling to 55-65℃. Stir evenly, and add each component of the men's oil-controlling and acne-removing composition after the temperature drops to 35-45℃. Stir evenly, and finally add the pH adjuster to adjust the pH to obtain the oil-controlling and acne-removing lotion.

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