Biphenyloxadiazole compounds or salts thereof, preparation method and application thereof

Abstract

A kind of diphenyl oxadiazole compound or its salt, its preparation method and application, diphenyl oxadiazole compound has the structure shown in formula (I), wherein R1It is at least independently selected from hydrogen, halogen, cyano, nitro, C1-6Alkyl, C1-6Alkoxy, C3-8Cycloalkyl, aryl, heteroaryl or heterocyclic group, n is 1~7.The diphenyl oxadiazole alkane compound or its pharmaceutically acceptable salt can be used to prepare the drug for preventing and / or treating pain.Especially, the diphenyl oxadiazole compound can be targeted HDAC6 to treat pain, has inhibitory effect on proinflammatory factors, and when the administration dose is 30 mg / kg, the inhibitory activity on pain model mouse is equivalent to ACY-1215, provides a new path for the treatment and prevention of moderate to severe pain, acute pain, chronic pain, neuropathic pain, inflammatory pain, nociceptive pain, cancer pain, hyperalgesia and visceral pain.

Images