A process for the preparation of a compound containing a nitrogen-containing bridged ring
CN121108143BActive Publication Date: 2026-08-28LEADING PHARMACEUTICAL (SHAOXING) CO LTD
Patent Information
- Application Number
- CN202511246315.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2025-09-02
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2045-09-02
AI Technical Summary
Technical Problem
该方法克服了现有技术中路线复杂，纯化困难的缺陷，在降低生产成本以及适于商业化放大生产方面具有显著优势
Benefits of technology
[0145]2、原料易得、副反应少、收率高，可显著降低生产成本。
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure CN121108143B_ABST
Abstract
The application discloses a preparation method of a compound containing a nitrogen-containing hetero-bridged ring. The application provides a preparation method of a compound of formula I, which comprises the following steps: (i) reacting a compound of formula II and a Grignard reagent R 2 MgX in a solvent, and the reaction is carried out at -30°C to -5°C to obtain a reaction solution; (ii) performing a hydrolysis reaction on the reaction solution of step (i) in a solvent in the presence of an inorganic base to obtain the compound of formula I. The method overcomes the defects of a complex route and difficult purification in the prior art, and has significant advantages in reducing production cost and being suitable for commercial scale-up production.
Need to check novelty before this filing date? Find Prior Art
Citation Information
Patent Citations
KRAS g12d inhibitors
WO2021041671A1
Pyrimidine-fused cyclic compound and preparation method and use thereof
WO2023030385A1
Aza-tetracyclic oxazepine compounds and uses thereof
WO2023225302A1
KRAS g12c degradation agent, and preparation method and use therefor
WO2024083258A1
Substituted heteroaromatic ring dihydropyrimidinone derivative as well as preparation method and medical application thereof
CN112390818A