Application of detection biomarker in preparation of product for diagnosing or treating high-salt diet kidney injury
By detecting CALB1 levels in urine and using AAV to upregulate CALB1 expression in the kidneys, the problem of early identification and treatment of kidney damage caused by high-salt diets has been solved, enabling early prevention and treatment of kidney damage.
CN121114458APending Publication Date: 2025-12-12ZHU XIANYI MEMORIAL HOSPITAL OF TIANJIN MEDICAL UNIV (TIANJIN MEDICAL UNIV METABOLIC DISEASE HOSPITAL TIANJIN METABOLIC DISEASE PREVENTION CENT)
Patent Information
- Application Number
- CN202511658942.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-13
- Publication Date
- 2025-12-12
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Figure CN121114458A_ABST
Abstract
The invention provides application of a detection biomarker in preparation of a product for diagnosing or treating high-salt diet kidney injury, and belongs to the technical field of biological medicine. The invention provides application of a detection biomarker in preparation of a product for diagnosis or treatment of high-salt diet kidney injury. The biomarker comprises CALB1. The CALB1 is used as a biomarker of the high-salt diet kidney injury, the level of the CALB1 in urine of a patient is absolutely quantified through an ELISA technology, and the CALB1 has great clinical value and practical significance in early discovery and intervention of the high-salt diet kidney injury. The CALB1 protein is taken as a treatment target, the expression of the CALB1 in the kidney is up-regulated through the AAV, and the accumulation of kidney senescence cells can be reduced, so that the kidney injury is improved, a new thought is provided for preventing and treating the kidney injury caused by high NaCl diet, and the early recognition and effective treatment of the high salt intake type kidney injury can be better realized.
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Citation Information
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