一种基于改性沸石的新型多层复合止血纱布及其制备方法

By utilizing the synergistic effect of the multi-layered composite structure of zeolite hemostatic gauze, the problem of balancing rapid hemostasis and safety in existing hemostatic materials is solved. This achieves rapid and safe hemostasis while providing antibacterial and healing-promoting functions to meet complex clinical needs.

CN121154891BActive Publication Date: 2026-07-17THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL +1

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
THE FIRST MEDICAL CENT CHINESE PLA GENERAL HOSPITAL
Filing Date
2025-09-22
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing hemostatic materials struggle to balance rapid hemostasis with safety. Traditional cellulose gauze absorbs too much blood, leading to increased blood loss. Improved zeolite gauze has a long clotting time and lacks healing-promoting properties. Kaolin composite materials cannot solve the problem of deep bleeding. Existing materials often focus on hemostasis while neglecting comprehensive needs such as antibacterial properties, healing promotion, and temperature control.

Method used

The zeolite hemostatic gauze with a multi-layer composite structure has an inner modified zeolite core layer that increases Ca2+ content through ion exchange and loads prothrombin activator, a middle temperature-controlled buffer layer containing calcium alginate/polyethylene glycol hydrogel layer and phase change microcapsules, and an outer layer of plasma-treated viscose fiber/silk blended gauze, which synergistically improves hemostatic efficiency and safety.

Benefits of technology

It significantly shortens clotting time, reduces exothermic peak temperature, achieves rapid and safe hemostasis, and provides antibacterial and healing-promoting functions to meet complex clinical needs.

✦ Generated by Eureka AI based on patent content.

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Abstract

本发明提供一种基于改性沸石的新型多层复合止血纱布及其制备方法,所述纱布由内至外包括:改性沸石核心层,通过离子交换将Ca2+含量提升至6‑13wt%,并负载0.4‑1.2wt%的凝血酶原激活物,高钙沸石促进血小板激活,凝血时间缩短至常规产品的46.7%。温控缓冲层,5‑10μm厚的海藻酸钙 / 聚乙二醇水凝胶层,含3‑5wt%相变材料(十八烷微胶囊),相变材料在42℃时发生相变吸热,将沸石放热峰值控制在42℃以下。外层载体,经等离子处理的粘胶纤维 / 蚕丝混纺纱布。所述的多层复合沸石止血纱布可以应用于战创伤急救、外科手术止血及抗凝治疗患者出血控制的医疗器械中。
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