一种达罗他胺衍生物及其制备方法与用途
By modifying the structure of dalolactam, a long-acting prodrug was prepared, which solved the problem of low bioavailability of oral dalolactam formulations, achieving high compliance and stable therapeutic effects, and making it suitable for long-acting dosing regimens.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ANHUI IPCKE PHARMACEUTICAL TECHNOLOGY DEVELOPMENT CO LTD
- Filing Date
- 2025-09-25
- Publication Date
- 2026-07-17
AI Technical Summary
Existing oral formulations of darotamid have low bioavailability, require frequent administration of high doses, resulting in significant side effects and poor patient compliance. Furthermore, there are currently no long-acting parenteral formulations to meet the needs of long-term treatment.
By modifying the structure of dalolactamine, a prodrug with long-acting properties is prepared, forming a formulation that can be injected intramuscularly, subcutaneously, or intravenously. After injection, it forms a drug reservoir in the body, slowly and continuously releasing dalolactamine and prolonging the duration of action.
It improves the bioavailability of darotamide, eliminates the food effect, reduces the frequency of administration, maintains stable therapeutic plasma levels, and is suitable for weekly, monthly or even longer dosing, thus improving patient compliance.
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Abstract
Citation Information
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