一种具有疫苗免疫增强作用的蒲公英多糖PLGA纳米颗粒的制备方法
The preparation of dandelion polysaccharide PLGA nanoparticles by emulsification-solvent evaporation method solves the problems of low drug loading, low release rate and poor stability, and realizes the preparation of dandelion polysaccharide PLGA nanoparticles with high encapsulation and high release rates, which are suitable for vaccine drugs.
CN121243366BActive Publication Date: 2026-07-17HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- HENAN UNIV OF ANIMAL HUSBANDRY & ECONOMY
- Filing Date
- 2025-11-26
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing dandelion polysaccharide PLGA nanoparticles have low drug loading, low release rate, and poor stability, which limits their application value in organisms.
Method used
Dandelion polysaccharide PLGA nanoparticles were prepared by emulsification-solvent evaporation method, with the average particle size controlled at 80-120 nm and the zeta potential maintained at -35.5±0.5 mV. The drug-polymer ratio was optimized to improve the encapsulation efficiency to ≥84% and the release rate at 24 h to ≥83%.
Benefits of technology
Dandelion polysaccharide (PLGA) nanoparticles with high encapsulation efficiency, high release rate, and stability were prepared, which are suitable for vaccine drugs and have the effect of enhancing vaccine immunity.
✦ Generated by Eureka AI based on patent content.
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Figure CN121243366B_ABST
Abstract
本发明涉及生物药品制造领域，具体为一种具有疫苗免疫增强作用的蒲公英多糖PLGA纳米颗粒的制备方法，所述蒲公英多糖PLGA纳米颗粒的平均粒度为80‑120 nm，Zeta电势为‑35.5±0.5mV，包封率≥84%，24 h释放率≥83%。本方案制得了包封率≥84%，载药量≥4.5%，24 h释放率≥83%且能够稳定储存的蒲公英多糖PLGA纳米颗粒，能够应用于疫苗药物，具有疫苗免疫增强作用。
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