一种stapled策略修饰的多肽及其应用
By introducing a stapled strategy that incorporates a full hydrocarbon backbone side chain at specific sites in the peptide sequence to form a stapled structure, the stability and endosomal escape problems of peptide vectors are solved, enabling efficient nucleic acid delivery and cancer therapy.
CN121248795BActive Publication Date: 2026-07-17ACADEMY OF MILITARY MEDICAL SCIENCES
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ACADEMY OF MILITARY MEDICAL SCIENCES
- Filing Date
- 2025-09-18
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing polypeptide vectors are prone to endosome escape during gene delivery due to endosome disintegration. This includes issues related to polypeptide vector stability, such as insufficient stability.
Method used
A series of peptide vectors with stapled modification were designed and synthesized. By introducing all-carbon backbone side chains at specific sites in the peptide sequence, a stapled structure was formed, which improved the stability and cell permeability of the peptides and enhanced the endosome escape ability.
Benefits of technology
It improves the stability and delivery efficiency of peptide carriers, enhances the ability to deliver nucleic acids, and shows significant therapeutic effects, especially in cancer treatment.
✦ Generated by Eureka AI based on patent content.
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Figure CN121248795B_ABST
Abstract
本发明属于生物医药技术领域，具体涉及一种stapled策略修饰的多肽及其应用。本发明设计合成的含有stapled修饰的含透膜肽及α螺旋片段的多肽以及多肽载体。本发明提供的多肽以及多肽载体其具有良好递送能力、稳定性及生物相容性，且毒性较低，可以有效提高核酸或药物的细胞递送、内涵体逃逸等问题。经过stapled修饰后，多肽载体的稳定性也得到大幅提升，具备作为递送载体开发的潜力。
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