Construction method and application of inflammatory aging skin model
CN121294328APending Publication Date: 2026-01-09HANGZHOU HUANTE BIOLOGICAL TECH CO LTD
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Patent Information
- Application Number
- CN202511614983.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-11-06
- Publication Date
- 2026-01-09
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Figure CN121294328A_ABST
Abstract
The invention relates to the technical field of skin explant model construction, and discloses a construction method and application of an inflammatory aging skin model. The construction method of the inflammatory aging skin model comprises the following steps: performing ultraviolet A and ultraviolet B radiation on a human skin explant, with the radiation dose of the ultraviolet A being 10-11 J / cm < 2 >, and then culturing the human skin explant in a culture medium without ultraviolet radiation for 23-25 h; the human skin explant is subjected to ultraviolet ray A radiation and ultraviolet ray B radiation again, the radiation dose of the ultraviolet ray A is 5-6 J / cm < 2 >, and then the human skin explant is cultured for 70-75 h in the culture medium without ultraviolet radiation. The inflammatory aging skin model constructed by the invention can simulate the inflammatory aging condition of the human skin more truly, and can well reflect the anti-inflammatory aging effect of the sample to be detected.
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Citation Information
Patent Citations
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