A sleep-improving composition based on the synergistic improvement of neuromodulation and liver protection and application thereof

Abstract

The application belongs to the technical field of health food, and discloses a sleep-improving composition based on the synergy of nerve regulation and liver protection and application thereof. The sleep-improving composition based on the synergy of nerve regulation and liver protection comprises a nerve calming module and a liver protection module, and the sleep is improved through the synergy of the two. The nerve calming module comprises jujube kernel peptide, gamma-aminobutyric acid (GABA) and tea theanine, and the liver protection module comprises sea buckthorn powder (sea buckthorn peptide) and glutathione-rich yeast. The composition regulates the central nervous system and the oxidation-reduction homeostasis of the body through multiple targets, and especially protects liver function to achieve the synergy of improving sleep.

Description

Technical Field

[0001] This invention relates to the field of health food technology, specifically to a sleep-improving composition based on the synergistic effects of nerve regulation and liver protection, and its application. Background Technology

[0002] Sleep disorders are closely linked to increasing mental stress and unhealthy lifestyles. Current sleep improvement products on the market have significant limitations: (1) Single target, treating the symptoms but not the root cause: Mainstream products such as γ-aminobutyric acid (GABA) or melatonin only target nerve inhibition or rhythm regulation, ignoring the fundamental impact of the body's internal environment (such as oxidative stress and metabolic burden) on sleep quality. Long-term use is prone to tolerance, and has limited effect on improving deep sleep and post-wake feeling.

[0003] (2) The ingredients are piled up and lack synergistic logic: Some compound formulas simply list sleep-aiding ingredients (such as GABA, theanine, valerian root, etc.) or use complex Chinese medicine compound formulas. The interaction mechanism between the ingredients is unclear and lacks modern pharmacological basis, resulting in the effect being only a simple superposition, or even having unpredictable antagonistic risks.

[0004] (3) Neglecting the key role of the "liver-brain axis" in sleep: Current technology has almost not paid attention to the direct link between liver health and sleep quality. Modern research clearly shows that as a core metabolic organ, the liver's dysfunction leading to the accumulation of oxidative stress products and the release of inflammatory factors will directly affect the function of the central nervous system through the circulatory system. This is an important reason for shallow sleep, vivid dreams, and fatigue after waking up.

[0005] Therefore, providing a composition that can simultaneously target the nervous system and protect the liver, and elucidating their synergistic mechanism, is a technical problem that urgently needs to be solved in this field. Summary of the Invention

[0006] The purpose of this invention is to overcome the shortcomings of the aforementioned background technology and provide a novel composition that not only quickly induces sleep but also improves overall sleep quality and the next day's mental state by improving the body's internal environment (especially focusing on liver protection). Specifically, this invention provides a sleep-improving composition based on neural regulation and liver protection and its application. This composition regulates the central nervous system and the body's redox homeostasis through multiple targets, and in particular, achieves synergistic sleep improvement by protecting liver function.

[0007] To achieve the objectives of this invention, the present invention provides a sleep-improving composition based on the synergistic effects of neuromodulation and liver protection, comprising a neurosedation module and a liver protection module. The synergistic effect of the two modules improves sleep. The neurosedation module contains jujube seed peptide, γ-aminobutyric acid (GABA), and tea theanine, while the liver protection module contains sea buckthorn powder (sea buckthorn peptide) and glutathione-rich yeast.

[0008] Furthermore, in some embodiments of the present invention, the mass ratio of jujube seed peptide, γ-aminobutyric acid and sea buckthorn powder in the composition is (1-1.5): (0.8-1.2): (0.8-1.2).

[0009] Furthermore, in some embodiments of the present invention, the composition also includes an antioxidant synergist.

[0010] Furthermore, in some embodiments of the present invention, the antioxidant synergistic component is beetroot juice powder.

[0011] Furthermore, in some embodiments of the present invention, the composition further comprises prebiotics.

[0012] Furthermore, in some embodiments of the present invention, the prebiotic is fructooligosaccharide and / or polydextrose, which are both prebiotics and carriers.

[0013] Furthermore, in some embodiments of the present invention, the mass ratio of jujube seed peptide, γ-aminobutyric acid, tea theanine, sea buckthorn powder, glutathione-enriched yeast, and red beet juice powder in the composition is (10-15):(8-12):(4-6):(8-12):(2.5-3.5):(2-3).

[0014] Furthermore, in some embodiments of the present invention, the composition comprises, per 25 ml unit: 100-150 mg of jujube seed peptide γ-aminobutyric acid 80-120 mg Tea theanine 40-60 mg Sea buckthorn powder 80-120 mg Glutathione-rich yeast: 25-35 mg Red beet juice powder: 20-30 mg.

[0015] Furthermore, in some embodiments of the present invention, the composition comprises, per 25 ml unit: 100-150 mg of jujube seed peptide γ-aminobutyric acid 80-120 mg Tea theanine 40-60 mg Sea buckthorn powder 80-120 mg Glutathione-rich yeast: 25-35 mg Red beet juice powder: 20-30 mg Fructooligosaccharides: 1.5-2.5g Polydextrose: 1-2g.

[0016] In another aspect, the present invention also provides a method for preparing the aforementioned sleep-improving composition based on neuromodulation and liver protection, the method comprising the steps of mixing, dissolving, adjusting the volume, and sterilizing the components.

[0017] On the other hand, the present invention also provides an application of the aforementioned sleep-improving composition based on synergistic effects of neuromodulation and liver protection, wherein the application is to use the composition to prepare food or health products that improve sleep.

[0018] Furthermore, in some embodiments of the present invention, the improvement of sleep includes shortening the sleep latency, prolonging sleep time and / or improving mental state upon waking.

[0019] Compared with the prior art, the advantages of the present invention are as follows: This invention proposes a novel "liver-brain synergistic" mechanism of action, demonstrating significant innovation. For the first time in the health food field, liver protection is explicitly identified as one of the core targets for improving sleep, and it is organically combined with traditional nerve-sedating targets. Its mechanism of action is clear: • Nerve Sedation Module (Symptomatic Treatment): Jujube seed peptide (a modern application of traditional sedative substances) works synergistically with GABA (a direct inhibitory neurotransmitter) and theanine (a brain wave that promotes relaxation) to quickly and safely relieve central nervous system tension and promote sleep.

[0020] • Liver Protection Module (Root Cause Treatment): The core of this module consists of sea buckthorn powder (sea buckthorn peptides) and glutathione-rich yeast. The flavonoids and vitamin C in sea buckthorn powder, combined with glutathione (a core antioxidant in the body), form a powerful endogenous oxidative stress clearance network, significantly reducing the metabolic burden on the liver and protecting liver cells from damage. A healthy liver can more effectively remove metabolic waste from the body, creating a clean, low-inflammatory internal environment for the brain, thereby fundamentally ensuring deep and stable sleep.

[0021] • Synergistic effect: The two modules are not simply added together, but rather mutually reinforcing. Nerve calming reduces the damage of stress to the liver; liver protection cuts off the pathways through which endogenous toxins interfere with sleep, resulting in a more lasting nerve calming effect and a better state after waking up. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to embodiments. Additional aspects and advantages of this invention will be set forth in part in the description which follows, and in part will be obvious from the description, or may be learned by practice of the invention. It should be understood that the following description is merely illustrative and not intended to limit the invention.

[0023] When a quantity, concentration, or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper and lower preferred values, this should be understood as specifically disclosing all ranges formed by any pair of any upper or preferred value with any lower or preferred value, regardless of whether the range is disclosed individually. For example, when the range “1 to 5” is disclosed, the described range should be interpreted as including the ranges “1 to 4”, “1 to 3”, “1 to 2”, “1 to 2 and 4 to 5”, “1 to 3 and 5”, etc. When numerical ranges are described herein, unless otherwise stated, the range is intended to include its endpoints and all integers and fractions within that range.

[0024] The indefinite articles “a” and “an” preceding an element or component of this invention do not impose any limitation on the quantity (i.e., number of times) of the element or component. Therefore, “an” or “a” should be interpreted as including one or at least one, and the singular form of an element or component also includes the plural form, unless the quantity clearly refers only to the singular form.

[0025] Furthermore, the terms "one embodiment," "some embodiments," "example," "specific example," or "some examples," etc., described below refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the present invention. In this specification, the illustrative expressions of the above terms are not necessarily directed at the same embodiment or example. Moreover, the technical features involved in the various embodiments of the present invention can be combined with each other as long as they do not conflict with each other.

[0026] Example 1 Formula of the sleep-improving composition (per 25ml): Ziziphus jujuba seed peptide: 125mg γ-Aminobutyric acid (GABA): 100mg Tea theanine: 50mg Sea buckthorn powder (sea buckthorn peptide): 100mg Glutathione-rich yeast: 30mg Red beet juice powder: 25mg Fructooligosaccharides: 2.0g Polydextrose: 1.5g Purified water, flavoring agent: appropriate amount Preparation process: (1) Dissolve fructooligosaccharides and polydextrose in an appropriate amount of purified water and stir until completely dissolved to obtain a clear sugar solution; (2) Under continuous high-speed stirring, sea buckthorn powder, red beet juice powder, glutathione-rich yeast, jujube seed peptide, tea theanine and GABA are slowly added to the sugar solution in sequence to ensure that each component is fully and evenly dispersed. (3) Add purified water to a final volume of 25 ml and stir well; (4) After filtration through a 0.45μm microporous membrane, the solution is filled into oral liquid bottles, sterilized at 121℃ for 15 minutes, and then cooled to obtain the product.

[0027] Example 2 Formula of the sleep-improving composition (per 25ml): Ziziphus jujuba seed peptide: 100mg γ-Aminobutyric acid (GABA): 80mg Tea theanine: 40mg Sea buckthorn powder (sea buckthorn peptide): 80mg Glutathione-rich yeast: 25mg Red beet juice powder: 20mg Fructooligosaccharides: 1.5g Polydextrose: 1g Purified water, flavoring agent: appropriate amount The preparation process is the same as in Example 1.

[0028] Example 3 Formula of the sleep-improving composition (per 25ml): Ziziphus jujuba seed peptide: 150mg γ-Aminobutyric acid (GABA): 120mg Tea theanine: 60mg Sea buckthorn powder (sea buckthorn peptide): 120mg Glutathione-rich yeast: 35mg Red beet juice powder: 30mg Fructooligosaccharides: 2.5g Polydextrose: 2g Purified water, flavoring agent: appropriate amount The preparation process is the same as in Example 1.

[0029] Comparative Example 1 Compared with Example 1, Comparative Example 1 does not contain jujube seed peptide.

[0030] Comparative Example 2 Comparative Example 2 does not contain γ-aminobutyric acid compared to Example 1.

[0031] Comparative Example 3 Compared with Example 1, Comparative Example 1 does not contain theanine from tea leaves.

[0032] Comparative Example 4 Comparative Example 1 does not contain sea buckthorn powder compared to Example 1.

[0033] Comparative Example 5 Compared with Example 1, Comparative Example 1 does not contain glutathione-enriched yeast.

[0034] Comparative Example 6 Compared with Example 1, Comparative Example 1 does not contain red beet juice powder.

[0035] Comparative Example 7 Formula of the sleep-improving composition (per 25ml): Ziziphus jujuba seed peptide: 80mg γ-Aminobutyric acid (GABA): 130mg Tea theanine: 50mg Sea buckthorn powder (sea buckthorn peptide): 130mg Glutathione-rich yeast: 30mg Red beet juice powder: 25mg Fructooligosaccharides: 2.0g Polydextrose: 1.5g Purified water, flavoring agent: appropriate amount The preparation process is the same as in Example 1.

[0036] Comparative Example 8 Formula of the sleep-improving composition (per 25ml): Ziziphus jujuba seed peptide: 170mg γ-Aminobutyric acid (GABA): 60mg Tea theanine: 50mg Sea buckthorn powder (sea buckthorn peptide): 60mg Glutathione-rich yeast: 30mg Red beet juice powder: 25mg Fructooligosaccharides: 2.0g Polydextrose: 1.5g Purified water, flavoring agent: appropriate amount The preparation process is the same as in Example 1.

[0037] Example of Effect: Verification of Synergistic Sleep Improvement Several healthy male ICR mice aged 6-8 weeks were randomly divided into four groups: a blank control group (distilled water), comparative group 1, comparative group 2, comparative group 3, comparative group 4, comparative group 5, comparative group 6, comparative group 7, comparative group 8, example group 1, example group 2, and example group 3, with 10 mice in each group. After continuous gavage administration of the drug (0.1 mL / 10 g) for 14 days, a pentobarbital sodium-induced sleep experiment was conducted. The experimental results were averaged and are shown in the table below.

[0038]

[0039] Results: Compared with the blank control group, all treatment groups prolonged sleep time. In prolonging the sleep time induced by sodium pentobarbital, the groups in this invention were significantly more effective than the comparative group. This irrefutably demonstrates that the combination of "nerve sedation" and "liver protection" in this invention produces a non-obvious synergistic effect, rather than a simple additive one.

[0040] Furthermore, the levels of malondialdehyde (MDA) in the livers of mice in this invention group were significantly reduced, while the levels of superoxide dismutase (SOD) and glutathione (GSH) were significantly increased, providing direct evidence for the "liver protection" mechanism.

[0041] The embodiments and comparative examples of this invention demonstrate that the ratio of the jujube seed peptide, GABA and sea buckthorn powder (approximately 3:2:2) is the golden ratio for achieving the best synergistic effect. This ratio ensures that the functions of each module are balanced, the cost is controllable, and the potential risks that may be caused by excessive amounts of a single component are avoided.

[0042] Those skilled in the art will readily understand that the above description is merely a partial example of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the present invention.

Claims

1. A sleep-improving composition based on synergistic effects of neuromodulation and liver protection, characterized in that, The composition comprises a nerve-sedating module and a liver-protecting module, which improve sleep through their synergistic effect. The nerve-sedating module contains jujube seed peptide, γ-aminobutyric acid and tea theanine, and the liver-protecting module contains sea buckthorn powder and glutathione-rich yeast. The mass ratio of jujube seed peptide, γ-aminobutyric acid and sea buckthorn powder in the composition is 150: 120: 120; The composition also contains an antioxidant synergist, which is beetroot juice powder; The composition also contains prebiotics, wherein the prebiotics are fructooligosaccharides and polydextrose; The composition comprises, per 25 ml unit: 150 mg of jujube seed peptide γ-aminobutyric acid 120 mg Tea Theanine 60 mg Sea buckthorn powder 120 mg Glutathione-rich yeast: 35 mg Red beet juice powder: 30 mg Fructooligosaccharides: 2.5g Polydextrose: 2g.

2. The sleep-improving composition based on neuromodulation and liver protection according to claim 1, characterized in that, The mass ratio of jujube seed peptide, γ-aminobutyric acid, tea theanine, sea buckthorn powder, glutathione-enriched yeast, and red beet juice powder in the composition is 150:120:60:120:35:

30.

3. The method for preparing the sleep-improving composition based on neuromodulation and liver protection as described in claim 1 or 2, characterized in that, The method includes the steps of mixing, dissolving, adjusting the volume, and sterilizing the components.

4. The application of the sleep-improving composition based on neuromodulation and liver protection as described in claim 1 or 2, characterized in that, The application is to use the composition in the preparation of food or health products that improve sleep.

5. The application of the sleep-improving composition based on neuromodulation and liver protection according to claim 4, characterized in that, The improvement of sleep includes shortening the sleep latency, prolonging sleep time and / or improving mental state upon waking.

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