A chip

By designing an automated centrifugal microfluidic chip, the automated synchronous quantitative mixing and washing of whole blood samples was realized, solving the accuracy and efficiency problems of quantitative detection of whole blood in the existing technology, and improving the sensitivity and specificity of the detection.

CN121314709BActive Publication Date: 2026-07-17YANTAI JIEZI BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YANTAI JIEZI BIOTECHNOLOGY CO LTD
Filing Date
2024-09-14
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing centrifugal microfluidic immunoassay techniques suffer from problems such as inaccurate plasma quantification and uneven reaction efficiency in whole blood quantitative detection, and the liquid flow control is complex, resulting in limited detection accuracy.

Method used

A chip was designed, comprising a first centrifugation zone, a second centrifugation zone, a third centrifugation zone, and a detection zone. It achieves automated synchronous quantitative mixing and automatic cleaning through centrifugal force, and uses a U-shaped capillary channel and multi-stage centrifugation zones for liquid flow control to realize the automatic mixing and cleaning of samples and buffer solutions.

Benefits of technology

It improves the reaction efficiency and sensitivity of the detection, reduces the workload of the detection personnel, realizes the automatic quantitative mixing and cleaning of samples and buffer solutions, and improves the accuracy and specificity of the detection.

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Abstract

This invention relates to the field of chip technology, specifically to a chip comprising a first, second, and third centrifugation zone and a detection zone. The first centrifugation zone includes a sample loading chamber and a first chamber. The second centrifugation zone includes a first quantitative chamber connected to the sample loading chamber via a type I channel and a third quantitative chamber connected to the first chamber via a type I channel. The third centrifugation zone includes a mixing chamber where the sample and buffer solution simultaneously enter under centrifugal force to form a mixture and react with the target reagent within the mixing chamber. This invention improves reaction efficiency and enhances the accuracy of detection results.
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