一种超分子组装体及其制备方法和应用
By using supramolecular assemblies formed by functional peptides modified with phenylboronic acid groups and polyphenol molecular binders, the problem of unstable binding between cationic peptide carriers and proteins was solved, achieving efficient intracellular delivery of proteins and maintenance of their biological activity.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- CHINA UNIV OF PETROLEUM (EAST CHINA)
- Filing Date
- 2025-10-29
- Publication Date
- 2026-07-17
AI Technical Summary
In existing technologies, cationic peptide carriers and proteins have difficulty forming stable complexes, which hinders the entry of proteins into cells, especially since there is electrostatic repulsion between positively charged proteins and peptide carriers.
Functional peptides modified with phenylboronic acid groups and polyphenol molecular binders are used to form supramolecular assemblies through non-covalent interactions. The polyphenol molecular binders bind to catechol groups on the protein surface to form dynamic chemical bonds, which synergistically drive the transmembrane delivery of proteins by nanoscale complexes.
This method enables efficient and safe delivery of proteins into cells while maintaining their biological activity, reducing preparation costs, and exhibiting low cytotoxicity and good biocompatibility.
Smart Images
Figure CN121371199B_ABST