一种含银胶原蛋白海绵及其制备方法
By preparing a silver-containing collagen sponge through a chelation-stabilized microcapsule encapsulation composite system, the problem of short antibacterial duration was solved, and the sustained release of silver and the antibacterial properties were improved, making it suitable for wound repair.
CN121371278BActive Publication Date: 2026-07-17ROOSIN MEDICAL CO LTD
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- ROOSIN MEDICAL CO LTD
- Filing Date
- 2025-12-12
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
Existing silver-containing collagen sponges have short-lasting antibacterial effects, which limits their application in wound repair.
Method used
By chelating and stabilizing a microcapsule-encapsulated composite system to isolate oxygen from silver ions, a combination of silver salt, glutathione, disodium EDTA, sodium alginate, and chitosan was used to form a homogenized solution, which was then freeze-dried to prepare silver-containing collagen sponges.
Benefits of technology
It significantly reduces the oxidation rate of silver ions, achieves sustained release of silver, prolongs the antibacterial effect, improves the antibacterial rate and reduces the cytotoxicity of silver ions, and is suitable for large-scale production.
✦ Generated by Eureka AI based on patent content.
Abstract
本发明涉及生物医用材料技术领域，尤其涉及一种含银胶原蛋白海绵及其制备方法，制备方法包括如下步骤：S1：在胶原蛋白溶液中加入银盐，得到第一溶液；S2：在所述第一溶液中加入谷胱甘肽与乙二胺四乙酸二钠，得到第二溶液；S3：在所述第二溶液中加入海藻酸钠与壳聚糖，均质，得到均质液；S4：对所述均质液进行冷冻干燥，得到含银胶原蛋白海绵。本发明提供的含银胶原蛋白海绵的制备方法，工艺简洁、重现性好、适合规模化生产；通过采用螯合稳定结合微胶囊包覆复合体系，隔绝氧气与银离子接触，显著降低银离子氧化速率，同时实现银的缓释，从而能够延长含银胶原蛋白海绵的抗菌时效。
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