一种用于肝癌早期诊断的血浆piRNA组合及应用
By combining plasma piRNA and using a Lasso Logistic regression model, the problems of delay and inaccuracy in the early diagnosis of liver cancer were solved, achieving efficient and accurate liver cancer screening and diagnosis, while reducing detection costs and technical barriers.
CN121380351BActive Publication Date: 2026-07-17THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- THE FIRST AFFILIATED HOSPITAL OF WENZHOU MEDICAL UNIV
- Filing Date
- 2025-12-24
- Publication Date
- 2026-07-17
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Figure CN121380351B_ABST
Abstract
本发明公开了一种用于肝癌早期诊断的血浆piRNA组合及应用，所述血浆piRNA组合由以下血浆piRNA组成：hsa‑piR‑23942、hsa‑piR‑9512、hsa‑piR‑22260和hsa‑piR‑14565。本发明基于中国人群的血浆piRNA表达谱，得到了用于肝癌早期诊断的血浆piRNA组合，并基于血浆piRNA组合建立了肝癌早期诊断试剂盒，该肝癌早期诊断试剂盒能够较为准确的预测肝癌早期发病风险，有助于降低检测的成本，同时本发明使用了Lasso Logistic回归模型，使模型纳入的变量数目大幅度降低，便于模型的应用推广。
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