A mass spectrometer for blood sample analysis

Abstract

The application discloses a mass spectrometer for blood sample analysis and relates to the technical field of mass spectrometers.The mass spectrometer comprises a base, a mechanical gripper, a stable seat, a mounting seat, an extraction needle, a driving assembly, a mounting assembly, a shaking assembly and a bubble removing assembly.When the blood sample is subjected to mass spectrum analysis, the blood sample tube can be placed on the shaking assembly, then the shaking assembly is placed on the mounting assembly, the mounted shaking assembly is automatically connected with the driving assembly, the mechanical gripper grasps the blood sample tube on the shaking assembly to the stable seat, the extraction needle is inserted into the blood sample tube to extract the blood sample for mass spectrum detection, the driving assembly drives the shaking assembly to shake during the detection process, thereby driving the blood sample tube to shake, so that the blood sample cell is prevented from being settled and layered, and the bubble removing assembly simultaneously knocks and vibrates the bottom of the blood sample tube during the shaking process, so that the bubbles in the blood sample tube are prevented from being formed.

Description

Technical Field

[0001] This invention relates to the field of mass spectrometry technology, specifically a mass spectrometer for blood sample analysis. Background Technology

[0002] In the field of blood sample analysis, mass spectrometry, as a highly sensitive and specific analytical tool, is widely used in drug metabolism, toxicology screening, and biomarker detection. By combining the separation capabilities of liquid chromatography with the precise mass analysis of mass spectrometry, blood sample mass spectrometry can perform qualitative and quantitative analysis of trace components in complex biological samples. Typical applications include the detection of drug concentrations, metabolites, and illicit substances in blood samples.

[0003] In the current blood sample analysis mass spectrometer, the process of extracting and testing blood from each blood sample tube takes a certain amount of time. Therefore, when there are many blood sample tubes, the later blood sample tubes need to wait a long time before they can be detected. If the blood is left to stand in the blood sample tube for a long time, it is easy for hormones and enzymes to be inactivated, resulting in falsely low blood levels, and for cells to settle and stratify, resulting in uneven sampling, which can ultimately lead to incorrect clinical diagnosis.

[0004] Therefore, a mass spectrometer for blood sample analysis is proposed. Summary of the Invention

[0005] The purpose of this invention is to provide a mass spectrometer for blood sample analysis to solve the problems raised in the prior art.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a mass spectrometer for blood sample analysis, the mass spectrometer comprising a base, a mechanical gripper, a stabilizing base, a mounting base, an extraction needle, a drive assembly, a mounting assembly, a shaking assembly, and a defoaming assembly; the mechanical gripper, the stabilizing base, and the mounting base are all mounted on the base; the extraction needle is slidably connected to the mounting base; the drive assembly is disposed within the base; the mounting assembly is disposed on the upper surface of the base; the shaking assembly is placed on the mounting assembly; after the shaking assembly is placed on the mounting assembly, the shaking assembly will automatically dock with the drive assembly. The defoaming component is mounted on the shaking component and rotates with it. When performing mass spectrometry analysis on a blood sample, the blood sample tube can be placed on the shaking component, and then the shaking component can be placed on the mounting component. After being placed, the shaking component will automatically dock with the drive component. At this time, the mechanical gripper will grab the blood sample tube on the shaking component and place it on the stable seat. The extraction needle will be inserted into the blood sample tube to extract the blood sample for mass spectrometry detection. During the detection process, the drive component can drive the shaking component to shake, thereby causing the blood sample tube to shake. During the shaking process, the defoaming component will simultaneously knock and vibrate the bottom of the blood sample tube.

[0007] Preferably, the driving assembly includes a motor, a docking seat, a docking groove, a shrinkage groove, an arc-shaped insert plate, and an elastic element. The motor has four sets, all fixedly connected to the base. The docking seat is fixedly connected to the output shaft of the motor and rotatably connected to the base, with the top of the docking seat flush with the top surface of the base. The docking groove is formed on the docking seat, and the shrinkage groove is formed within the docking groove. The arc-shaped insert plate is slidably connected to the shrinkage groove, and the elastic element is installed between the shrinkage groove and the arc-shaped insert plate. When the motor is started, it drives the docking seat to rotate. After the docking seat docks with the rocking assembly, it drives the rocking assembly to shake.

[0008] Preferably, the mounting assembly includes a right-angle bracket, a rotating rod, and a locking plate; there are two sets of right-angle brackets, both of which are fixedly connected to the base; the rotating rod is rotatably connected to the right-angle bracket; and the locking plate is fixedly connected to the rotating rod. When the blood sample box is placed against the right angle of the right-angle bracket, the locking plate can be rotated to latch onto the top of the blood sample box, preventing the blood sample box from moving upward.

[0009] Preferably, the shaking assembly includes a blood sample box, a base plate, a rotating groove, a first gear, a second gear, an extension column, a folding plate, a fixing frame, ball bearings, a mounting tube, and a connecting rod; the blood sample box is placed between right-angled brackets, the base plate is fixedly connected to the bottom of the blood sample box, multiple sets of rotating grooves are formed on the blood sample box, both the first gear and the second gear are rotatably connected to the base and are located between the base plate and the base, multiple sets of the first gear are provided, and each set of the first gear is located below the rotating groove, multiple sets of the second gear are provided, and each set of the second gear is positioned between and meshes with four sets of the first gear, and the extension column is fixedly connected to the center of the first gear. The folding plate is fixedly connected to the extension column, the fixing frame is fixedly connected to the rotating groove, the ball bearing is rotatably connected to the center of the fixing frame, the mounting tube is fixedly connected to the ball bearing, and the connecting rod is fixedly connected between the ball bearing and the folding plate and is inclined. When the second gear rotates, the second gear will drive the four sets of first gears around it to rotate. The rotating first gear will drive the folding plate to rotate in the rotating groove through the extension column. The folding plate will drive the ball bearing to rotate along the center of the fixing frame through the inclined connecting rod, thereby driving the inclined mounting tube to rotate. The top of the blood sample tube in the mounting tube will rotate axially around the bottom center.

[0010] Preferably, a hemisphere is fixedly connected below the second gear. The hemisphere has an arc-shaped groove that matches the shape of the arc-shaped insert plate. The sphere matches the docking groove. After the blood sample box is placed between the right-angle brackets, the hemisphere below the second gear will automatically dock with the docking groove on the docking seat. When the motor is started to drive the docking seat to rotate, the rotating docking seat will drive the arc-shaped insert plate to rotate to the same angle as the arc-shaped groove below the hemisphere. At this time, the arc-shaped insert plate will be pushed by the elastic element and inserted into the arc-shaped groove. At this time, the rotating docking seat will drive the hemisphere and the second gear to rotate simultaneously through the arc-shaped insert plate.

[0011] Preferably, the base plate has a circular notch, and the bottom of the hemisphere extends out of the circular notch. When the blood sample box is placed between the right-angle brackets, the bottom of the hemisphere will be located in the docking groove. After the blood sample box is placed between the right-angle brackets, the hemisphere and the docking groove will automatically dock. When the blood sample box needs to be moved, it is only necessary to lift the blood sample box upward to separate the hemisphere from the docking groove.

[0012] Preferably, the defoaming assembly includes a fixed column, a rotating sleeve, external teeth, a threaded strip, a disc, internal teeth, a column, a sliding sleeve, a pressing rod, and a second elastic element; the fixed column is fixedly connected to the connecting rod, and the fixed column is vertically arranged; the rotating sleeve is rotatably connected to the fixed column; the external teeth are fixedly connected to the rotating sleeve; the threaded strip is fixedly connected to the rotating sleeve; the disc is fixedly connected to the rotating groove; the internal teeth are fixedly connected to the inner ring of the disc; the column is fixedly connected to the end of the folding plate; the sliding sleeve is slidably connected to the column; the pressing rod is fixedly connected to the sliding sleeve, and the end of the pressing rod extends below the threaded strip; the second elastic element is sleeved around the column and located between the sliding sleeve and the folding plate; during the rotation of the folding plate... This will cause the rotating sleeve and the column to rotate simultaneously around the extension column. Since the outer teeth of the rotating sleeve mesh with the inner teeth of the inner circle of the disc, the rotating sleeve itself will rotate around the fixed column during the rotation of the rotating sleeve around the extension column. During the rotation, the threaded strip on the outer circumference of the rotating sleeve will continuously press the sliding sleeve down along the column through the pressing rod to overcome the elastic force of the second elastic element until the pressing rod disengages from the lowest end of the threaded strip. The sliding sleeve will be pushed by the second elastic element and rebound instantly, striking the bottom of the ball. This realizes that during the rotation of the folding plate, the rotating sleeve continuously descends, stores energy, and rises again to strike the ball. In turn, the striking force is transmitted to the bottom of the blood sample tube through the sliding sleeve, which has a knocking vibration effect on the blood sample in the blood sample tube.

[0013] Preferably, limiting strips are fixedly connected to both sides of the column, and the sliding sleeve is slidably connected to the limiting strips and the column at the same time; the limiting strips restrict the sliding sleeve, so that the sliding sleeve can only slide up and down along the column, which can prevent the sliding sleeve itself from rotating with the column and causing the position of the pressing rod to shift.

[0014] Compared with the prior art, the beneficial effects of the present invention are: 1. This invention, by setting up a shaking component, can start a motor during the detection process. The motor will drive gear two to drive gear one to rotate. The rotating gear one will drive the folding plate to rotate in the rotating groove through the extension column. The folding plate will drive the ball to rotate along the center of the fixed frame through the inclined connecting rod, thereby driving the inclined mounting tube to rotate. The top of the blood sample tube in the mounting tube will rotate axially around the bottom center, thus producing a shaking effect on the blood sample in the blood sample tube, preventing blood cell sedimentation and stratification that would lead to uneven sampling.

[0015] 2. This invention, by setting up a defoaming component, causes the rotating sleeve and the column to rotate simultaneously around the extension column during the rotation of the folding plate. Since the outer teeth of the rotating sleeve mesh with the inner teeth of the inner circle of the disc, the rotating sleeve itself will rotate around the fixed column during the rotation of the rotating sleeve around the extension column. During the rotation, the threaded strip on the outer circumference of the rotating sleeve will continuously press the sliding sleeve down along the column against the elastic force of the second elastic element through the pressing rod until the pressing rod disengages from the lowest end of the threaded strip. The sliding sleeve will then rebound instantaneously under the thrust of the second elastic element, striking the bottom of the ball. This achieves the action of the rotating sleeve repeatedly descending, accumulating force, and then rising to strike the ball. The striking force is then transmitted to the bottom of the blood sample tube through the sliding sleeve, which has a knocking vibration effect on the blood sample in the blood sample tube, preventing the generation of air bubbles during shaking that would affect the accuracy of mass spectrometry detection.

[0016] 3. The detachable design of the blood sample box and installation components of this invention facilitates the installation of blood sample tubes on the blood sample box and makes it easy to replace the next blood sample box. At the same time, the operator only needs to complete the simple mechanical action of "placing the blood sample box" to automatically complete the mechanical connection between the blood sample box and the drive component, which improves the convenience of blood sample box installation and ensures the overall testing efficiency. Attached Figure Description

[0017] Figure 1 This is a three-dimensional structural diagram of the overall appearance of the present invention; Figure 2 This is a cross-sectional view of the base of the present invention; Figure 3 This is a schematic diagram of the drive component structure of the present invention; Figure 4 This is a schematic diagram of the installation component structure of the present invention; Figure 5 This is a schematic diagram of the shaking component structure of the present invention; Figure 6 This is a bottom view of the base plate of the present invention; Figure 7 This is a schematic diagram of the internal structure of the mounting component of the present invention; Figure 8This is a schematic diagram of the structure at the disk of the present invention; Figure 9 This is a schematic diagram of the defoaming component structure of the present invention.

[0018] In the diagram: 1. Base; 11. Mechanical gripper; 2. Stabilizing seat; 21. Mounting seat; 22. Extraction needle; 3. Drive assembly; 31. Motor; 32. Docking seat; 33. Docking groove; 34. Shrinkage groove; 35. Arc-shaped insert plate; 36. Elastic element one; 4. Mounting assembly; 41. Right-angle stop; 42. Rotating rod; 43. Clamping plate; 5. Shaking assembly; 51. Blood sample box; 52. Base plate; 521. Circular notch; 53. Rotating groove; 54. 55. Gear 1; 55. Gear 2; 551. Hemisphere; 552. Arc groove; 56. Extension column; 57. Folding plate; 58. Fixing frame; 59. Ball bearing; 510. Mounting tube; 511. Connecting rod; 6. Defoaming assembly; 61. Fixing column; 62. Rotating sleeve; 63. External tooth; 64. Threaded strip; 65. Disc; 66. Internal tooth; 67. Column; 671. Restricting strip; 68. Sliding sleeve; 69. Pressing rod; 610. Elastic element 2. Detailed Implementation

[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] Please see Figures 1 to 9 This invention provides a mass spectrometer for blood sample analysis, the technical solution of which is as follows: Reference Figure 1 and Figure 2A mass spectrometer for blood sample analysis includes a base 1, a mechanical gripper 11, a stabilizing base 2, a mounting base 21, an extraction needle 22, a drive assembly 3, a mounting assembly 4, a shaking assembly 5, and a defoaming assembly 6. The mechanical gripper 11, the stabilizing base 2, and the mounting base 21 are all mounted on the base 1. The extraction needle 22 is slidably connected to the mounting base 21. The drive assembly 3 is disposed within the base 1. The mounting assembly 4 is disposed on the upper surface of the base 1. The shaking assembly 5 is placed on the mounting assembly 4. After being placed on the mounting assembly 4, the shaking assembly 5 automatically engages with the drive assembly 3. The defoaming assembly 6 is disposed within the shaking assembly. The component 5 rotates along with the shaking component 5. When performing mass spectrometry analysis on a blood sample, the blood sample tube can be placed on the shaking component 5, and then the shaking component 5 can be placed on the mounting component 4. After being placed, the shaking component 5 will automatically dock with the driving component 3. At this time, the mechanical gripper 11 will grab the blood sample tube on the shaking component 5 and place it on the stable seat 2. The extraction needle 22 will be inserted into the blood sample tube to extract the blood sample for mass spectrometry detection. During the detection process, the driving component 3 can drive the shaking component 5 to shake, thereby causing the blood sample tube to shake, preventing the blood sample cells from settling and stratifying. During the shaking process, the defoaming component 6 will simultaneously knock and vibrate the bottom of the blood sample tube to prevent the formation of air bubbles inside the blood sample tube.

[0021] Reference Figure 2 and Figure 3 The driving component 3 includes a motor 31, a docking seat 32, a docking groove 33, a shrinkage groove 34, an arc-shaped insert plate 35, and an elastic element 36. The motor 31 has four sets, all fixedly connected to the base 1. The docking seat 32 is fixedly connected to the output shaft of the motor 31 and rotatably connected to the base 1, with the top of the docking seat 32 flush with the top surface of the base 1. The docking groove 33 is formed on the docking seat 32, and the shrinkage groove 34 is formed within the docking groove 33. The arc-shaped insert plate 35 is slidably connected to the shrinkage groove 34. The elastic element 36 is installed between the shrinkage groove 34 and the arc-shaped insert plate 35. When the motor 31 is started, it drives the docking seat 32 to rotate. After the docking seat 32 docks with the rocking component 5, it drives the rocking component 5 to shake.

[0022] Reference Figure 4 The mounting assembly 4 includes a right-angle bracket 41, a rotating rod 42, and a locking plate 43. There are two sets of right-angle brackets 41, both of which are fixedly connected to the base 1. The rotating rod 42 is rotatably connected to the right-angle bracket 41, and the locking plate 43 is fixedly connected to the rotating rod 42. When the blood sample box 51 is placed against the right angle of the right-angle bracket 41, the locking plate 43 can be rotated to latch onto the top of the blood sample box 51, preventing the blood sample box 51 from moving upward.

[0023] Reference Figures 5 to 7The shaking assembly 5 includes a blood sample box 51, a base plate 52, a rotating groove 53, a first gear 54, a second gear 55, an extension column 56, a folding plate 57, a fixing frame 58, a ball bearing 59, a mounting tube 510, and a connecting rod 511. The blood sample box 51 is placed between right-angle brackets 41. The base plate 52 is fixedly connected to the bottom of the blood sample box 51. Multiple sets of rotating grooves 53 are formed on the blood sample box 51. The first gear 54 and the second gear 55 are rotatably connected to the base 1 and are located between the base plate 52 and the base 1. Multiple sets of the first gear 54 are provided, and each set of the first gear 54 is located below the rotating groove 53. Multiple sets of the second gear 55 are provided, and each set of the second gear 55 is arranged between and meshes with four sets of the first gear 54. The extension column 56 is fixedly connected to the center of the first gear 54. The folding plate 57... 7 is fixedly connected to the extension column 56, the fixing frame 58 is fixedly connected to the rotating groove 53, the ball bearing 59 is rotatably connected to the center position of the fixing frame 58, the mounting tube 510 is fixedly connected to the ball bearing 59, and the connecting rod 511 is fixedly connected between the ball bearing 59 and the folding plate 57 and is inclined; when the gear 2 55 rotates, the gear 2 55 will drive the four sets of gear 1 54 around it to rotate. The rotating gear 1 54 will drive the folding plate 57 to rotate in the rotating groove 53 through the extension column 56. The folding plate 57 will drive the ball bearing 59 to rotate along the center of the fixing frame 58 through the inclined connecting rod 511, thereby driving the inclined mounting tube 510 to rotate. The top of the blood sample tube in the mounting tube 510 will rotate axially around the bottom center, thus producing the effect of shaking the blood sample in the blood sample tube.

[0024] Reference Figure 6 and Figure 7 Below the second gear 55, a hemisphere 551 is fixedly connected. The hemisphere 551 has an arc-shaped groove 552 that matches the shape of the arc-shaped insert plate 35. The sphere matches the docking groove 33. After the blood sample box 51 is placed between the right-angle brackets 41, the hemisphere 551 below the second gear 55 will automatically engage with the docking groove 33 on the docking seat 32. At this time, the hemisphere 551 will press against the arc-shaped insert plate 35. 5. It overcomes the elastic force of the elastic element 36 and retracts into the shrinkage groove 34. When the starting motor 31 drives the docking seat 32 to rotate, the rotating docking seat 32 drives the arc-shaped insert plate 35 to rotate until the angle is consistent with the arc-shaped groove 552 below the hemisphere 551. The arc-shaped insert plate 35 will be pushed by the elastic element 36 and insert into the arc-shaped groove 552. At this time, the rotating docking seat 32 will drive the hemisphere 551 and the gear 55 to rotate simultaneously through the arc-shaped insert plate 35.

[0025] Reference Figure 2 and 6The base plate 52 has a circular notch 521, and the bottom of the hemisphere 551 extends out of the circular notch 521. When the blood sample box 51 is placed between the right-angle brackets 41, the bottom of the hemisphere 551 will be located in the docking groove 33. After the blood sample box 51 is placed between the right-angle brackets 41, the hemisphere 551 will automatically dock with the docking groove 33. When it is necessary to move the blood sample box 51, it is only necessary to lift the blood sample box 51 upward to separate the hemisphere 551 from the docking groove 33.

[0026] Reference Figure 8 and Figure 9 The defoaming assembly 6 includes a fixed post 61, a rotating sleeve 62, external teeth 63, a threaded strip 64, a disc 65, internal teeth 66, a column 67, a sliding sleeve 68, a pressing rod 69, and an elastic element 610. The fixed post 61 is fixedly connected to the connecting rod 511 and is vertically arranged. The rotating sleeve 62 is rotatably connected to the fixed post 61. The external teeth 63 are fixedly connected to the rotating sleeve 62, and the threaded strip 64 is fixedly connected to the rotating sleeve 62. The disc 65 is fixedly connected to the rotating groove 53, the internal teeth 66 are fixedly connected to the inner ring of the disc 65, the column 67 is fixedly connected to the end of the folding plate 57, the sliding sleeve 68 is slidably connected to the column 67, the pressing rod 69 is fixedly connected to the sliding sleeve 68, and the end of the pressing rod 69 extends below the threaded strip 64. The elastic element 610 is sleeved around the column 67 and located between the sliding sleeve 68 and the folding plate 57; during the rotation of the folding plate 57, the elastic element 610 will... The rotating sleeve 62 and the column 67 rotate simultaneously around the extension column 56. Since the outer teeth 63 of the outer circumference of the rotating sleeve 62 mesh with the inner teeth 66 of the inner circle of the disk 65, the rotating sleeve 62 itself will rotate around the fixed column 61 during the rotation of the rotating sleeve 62 around the extension column 56. During the rotation, the threaded strip 64 on the outer circumference of the rotating sleeve 62 will continuously press the sliding sleeve 68 along the column 67 through the pressing rod 69 to overcome the elastic force of the second elastic element 610 and descend until the pressing rod 69 disengages from the lowest end of the threaded strip 64. The sliding sleeve 68 will be pushed by the second elastic element 610 and rebound instantly, striking the bottom of the ball 59. This realizes that the rotating sleeve 62 repeatedly descends, stores energy, and rises again to strike the ball 59 during the rotation of the folding plate 57. In turn, the striking force is transmitted to the bottom of the blood sample tube through the sliding sleeve 68, which plays a knocking vibration role on the blood sample in the blood sample tube and prevents air bubbles from being generated during the shaking process, which would affect the accuracy of mass spectrometry detection.

[0027] Reference Figure 9 The column 67 is also fixedly connected to two sides of the column 67. The sliding sleeve 68 is slidably connected to the limiting strip 671 and the column 67. The limiting strip 671 restricts the sliding sleeve 68, so that the sliding sleeve 68 can only slide up and down along the column 67, which can prevent the sliding sleeve 68 and the column 67 from rotating and causing the position of the pressing rod 69 to shift.

[0028] Working principle: When performing mass spectrometry analysis on blood samples, the blood sample tube can be placed in the mounting tube 510 on the blood sample box 51. Then, the blood sample box 51 is placed against the right angle of the right angle bracket 41. At this time, the hemisphere 551 will automatically align with the docking groove 33. Then, the locking plate 43 can be rotated to lock the locking plate 43 above the blood sample box 51 to prevent the blood sample box 51 from moving upward. The mechanical gripper 11 will then grab the blood sample tube on the shaking component 5 and place it on the stable seat 2. The extraction needle 22 will be inserted into the blood sample tube to extract the blood sample for mass spectrometry detection.

[0029] During the testing process, motor 31 can be started, which will drive docking seat 32 to rotate. The rotating docking seat 32 will drive arc-shaped insert plate 35 to rotate until the angle is consistent with the arc-shaped groove 552 below hemisphere 551. At this time, arc-shaped insert plate 35 will be pushed by elastic element 36 and inserted into arc-shaped groove 552. At this time, the rotating docking seat 32 will drive hemisphere 551 and gear 2 55 to rotate through arc-shaped insert plate 35. Gear 2 55 will drive the four sets of gear 1 54 around it to rotate. The rotating gear 1 54 will drive the folding plate 57 to rotate in the rotating groove 53 through the extension column 56. The folding plate 57 will drive the ball 59 to rotate along the center of the fixed frame 58 through the inclined connecting rod 511, which will drive the inclined mounting tube 510 to rotate. The top of the blood sample tube in the mounting tube 510 will rotate axially around the bottom center, thus producing the effect of shaking the blood sample in the blood sample tube, preventing blood cell sedimentation and stratification, which would lead to uneven sampling.

[0030] During the rotation of the folding plate 57, the rotating sleeve 62 and the column 67 will also rotate around the extension column 56. Since the outer teeth 63 of the outer circumference of the rotating sleeve 62 mesh with the inner teeth 66 of the inner circle of the disc 65, the rotating sleeve 62 itself will rotate around the fixed column 61 during the rotation of the rotating sleeve 62 around the extension column 56. During the rotation, the threaded strip 64 on the outer circumference of the rotating sleeve 62 will continuously press the sliding sleeve 68 along the column 67 through the pressing rod 69, overcoming the elastic element 610. As the elastic force decreases until the pressing rod 69 disengages from the lowest end of the threaded strip 64, the sliding sleeve 68 will be pushed by the elastic element 610 and instantly rebound upwards, striking the bottom of the ball 59. This achieves the action of the rotating sleeve 62 repeatedly descending, accumulating force, and then rising again to strike the ball 59 during the rotation of the folding plate 57. In turn, the striking force is transmitted to the bottom of the blood sample tube through the sliding sleeve 68, which has a knocking and vibration effect on the blood sample in the blood sample tube, preventing air bubbles from being generated during the shaking process and affecting the accuracy of mass spectrometry detection.

[0031] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

Claims

1. A mass spectrometer for blood sample analysis, characterized in that: The mass spectrometer includes a base (1), a mechanical gripper (11), a stabilizing seat (2), a mounting seat (21), an extraction needle (22), a drive assembly (3), a mounting assembly (4), a shaking assembly (5), and a defoaming assembly (6). The mechanical gripper (11), the stabilizing seat (2), and the mounting seat (21) are all mounted on the base (1). The extraction needle (22) is slidably connected to the mounting seat (21). The drive assembly (3) is located inside the base (1). The mounting assembly (4) is located on the upper surface of the base (1). The shaking assembly (5) is placed on the mounting assembly (4). After the shaking assembly (5) is placed on the mounting assembly (4), the shaking assembly (5) will automatically dock with the drive assembly (3). The defoaming assembly (6) is located on the shaking assembly (5) and rotates with the shaking assembly (5). The drive assembly (3) includes a motor (31), a docking seat (32), a docking groove (33), a shrinkage groove (34), an arc-shaped insert plate (35), and an elastic element (36); the motor (31) has four sets and is fixedly connected to the base (1); the docking seat (32) is fixedly connected to the output shaft of the motor (31); the docking seat (32) is rotatably connected to the base (1); the top of the docking seat (32) is flush with the top surface of the base (1); the docking groove (33) is opened on the docking seat (32); the shrinkage groove (34) is opened in the docking groove (33); the arc-shaped insert plate (35) is slidably connected to the shrinkage groove (34); and the elastic element (36) is installed between the shrinkage groove (34) and the arc-shaped insert plate (35). The shaking assembly (5) includes a blood sample box (51), a base plate (52), a rotating groove (53), a gear one (54), a gear two (55), an extension column (56), a folding plate (57), a fixing frame (58), a ball bearing (59), a mounting tube (510), and a connecting rod (511). The blood sample box (51) is placed between right-angle brackets (41), the base plate (52) is fixedly connected to the bottom of the blood sample box (51), the rotating groove (53) is formed in multiple groups on the blood sample box (51), the gear one (54) and the gear two (55) are rotatably connected to the base (1) and are both located between the base plate (52) and the base (1). The gear one (54) is designed to... The gears are arranged in multiple sets, and each set of gear 1 (54) is located below the rotating groove (53). The gears 2 (55) are arranged in multiple sets, and each set of gear 2 (55) is arranged between and meshes with the four sets of gear 1 (54). The extension column (56) is fixedly connected to the center position of gear 1 (54). The folding plate (57) is fixedly connected to the extension column (56). The fixing frame (58) is fixedly connected to the rotating groove (53). The ball (59) is rotatably connected to the center position of the fixing frame (58). The mounting tube (510) is fixedly connected to the ball (59). The connecting rod (511) is fixedly connected between the ball (59) and the folding plate (57) and is inclined. The defoaming assembly (6) includes a fixed column (61), a rotating sleeve (62), external teeth (63), a threaded strip (64), a disc (65), internal teeth (66), a column (67), a sliding sleeve (68), a pressing rod (69), and an elastic element (610); the fixed column (61) is fixedly connected to the connecting rod (511), the fixed column (61) is vertically arranged, the rotating sleeve (62) is rotatably connected to the fixed column (61), the external teeth (63) is fixedly connected to the rotating sleeve (62), and the threaded strip (64) is fixedly connected to the connecting rod (511). The rotating sleeve (62) is fixedly connected, the disc (65) is fixedly connected to the rotating groove (53), the internal tooth (66) is fixedly connected to the inner ring of the disc (65), the column (67) is fixedly connected to the end of the folding plate (57), the sliding sleeve (68) is slidably connected to the column (67), the pressing rod (69) is fixedly connected to the sliding sleeve (68), the end of the pressing rod (69) extends to below the threaded strip (64), and the elastic element two (610) is sleeved around the column (67) and located between the sliding sleeve (68) and the folding plate (57).

2. The mass spectrometer for blood sample analysis according to claim 1, characterized in that: The installation assembly (4) includes a right-angle bracket (41), a rotating rod (42), and a clamping plate (43); the right-angle bracket (41) is provided in two sets and is fixedly connected to the base (1); the rotating rod (42) is rotatably connected to the right-angle bracket (41); and the clamping plate (43) is fixedly connected to the rotating rod (42).

3. A mass spectrometer for blood sample analysis according to claim 1, characterized in that: A hemisphere (551) is fixedly connected below the gear 2 (55). An arc groove (552) is provided on the hemisphere (551). The arc groove (552) matches the shape of the arc insert plate (35). The sphere matches the docking groove (33).

4. A mass spectrometer for blood sample analysis according to claim 3, characterized in that: A circular notch (521) is provided on the base plate (52), and a circular notch (521) extends from the bottom of the hemisphere (551). When the blood sample box (51) is placed between the right-angle brackets (41), the bottom of the hemisphere (551) will be located in the docking groove (33).

5. A mass spectrometer for blood sample analysis according to claim 1, characterized in that: The column (67) is also fixedly connected to two sides of the limiting strip (671), and the sliding sleeve (68) is slidably connected to the limiting strip (671) and the column (67) at the same time.

Images