一种PH-粘度双响应荧光探针、制备方法、应用
By designing a pH-viscosity dual-response fluorescent probe, the problem that fluorescent molecular probes in the existing technology cannot detect subtle changes in the early stage of thrombosis is solved, and the accurate detection of thrombosis formation time and evaluation of anticoagulant drugs are achieved, with high sensitivity and stability.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- NANJING STOMATOLOGICAL HOSPITAL
- Filing Date
- 2025-11-07
- Publication Date
- 2026-07-17
AI Technical Summary
Existing fluorescent molecular probes are unable to effectively detect subtle changes in the early stages of thrombus formation, especially with insufficient response to changes in pH and viscosity, making it difficult to accurately determine the timing and quality of thrombus formation.
A pH-viscosity dual-response fluorescent probe was designed. By introducing a proton-receptible weak base group, a pyridine ring, and a conjugated chain structure onto the fluorescent backbone, and combining it with a sulfonic acid group, the probe achieves a sensitive response to pH and viscosity, and emits a fluorescent signal in the near-infrared region, thereby improving the probe's water solubility and stability.
It enables precise detection of thrombus formation time, producing significant fluorescence signal changes even at early, minute changes, and linearly responds to thrombus density and maturity. It is suitable for rapid screening of thrombus formation time in vitro and evaluation of anticoagulant drugs.
Smart Images
Figure CN121405604B_ABST