一种秦艽提取物及其制备方法、应用
By precisely extracting and purifying Gentiana macrophylla extract, toxic components that may aggravate the condition are removed, and Gentiana macrophylla extract containing multiple active ingredients is prepared. This solves the problems of insufficient efficacy and safety in MASH treatment and provides an efficient, safe and controllable treatment plan.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- SHAANXI NORMAL UNIV
- Filing Date
- 2025-12-29
- Publication Date
- 2026-07-17
AI Technical Summary
Existing chemical and natural drugs have limitations in treating metabolic dysfunction-associated steatohepatitis (MASH), including issues with efficacy, safety, and patient compliance. In addition, the extract of the traditional Chinese medicine Gentiana macrophylla contains complex active ingredients and potentially toxic components that may aggravate the condition.
Gentiana macrophylla extract containing gentiopicroside, loganic acid, swertiamarin, and 6'-O-β-D-glucosylgentiopicroside was prepared by ethanol solution reflux extraction, petroleum ether extraction, and macroporous adsorption resin purification. This method removes toxic components that may aggravate the condition and improves efficacy and safety.
It significantly improves the damp-heat accumulation syndrome in the MASH model, restores liver function, reduces hepatic steatosis and inflammation, inhibits key pro-inflammatory factors, and provides an efficient, safe, and quality-controlled treatment plan.
Smart Images
Figure CN121445791B_ABST
Abstract
Citation Information
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